Results 321 to 330 of about 411,515 (387)

Risk Stratification for Cephalosporin-Induced Thrombocytopenia: Development and Validation of a Multidimensional Predictive Model in Older Adults. [PDF]

Risk Manag Healthc Policy
Li X, Lei W, Wang M, Xu L.
europepmc   +1 more source

A Case Study of Model‐Informed Drug Development of a Novel PCSK9 Antisense Oligonucleotide. Part 2: Phase 2 to Phase 3

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT In this second part of a case study on the practical use of model‐informed drug development (MIDD), we describe the clinical development of AZD8233, a novel proprotein convertase subtilisin/kexin type 9 (PCSK9) antisense oligonucleotide, from phase 2b to the start of phase 3.
Jane Knöchel, Catarina Nilsson, Björn Carlsson, Alexis Hofherr, Per Johanson, Tina Rydén‐Bergsten, Bengt Hamrén, Dinko Rekić   +7 more
wiley   +1 more source

Iguratimod alleviated Sjögren's syndrome through regulating macrophage polarization

Rheumatology &Autoimmunity, EarlyView.
Nonobese diabetic (NOD) mice exhibited characteristic of Sjögren's syndrome (SS), with increased M1 macrophages and deceased M2 macrophages. Iguratimod alleviated SS‐like symptoms and restored balance of macrophage polarization through inhibiting the mitogen‐activated protein kinases pathway in NOD mice.
Junqiao Guo, Yu Chen, Shumin Wang, Tingting Jiang, Yue Wang, Haolin Wu, Xiaojing Li, Genhong Yao   +7 more
wiley   +1 more source

Post-transfusion purpura in a 36-year-old woman. [PDF]

CMAJ
Hirunwidchayarat P, Raslan IA, Khandelwal A, Lee WL.   +3 more
europepmc   +1 more source

Long-term treatment with ruxolitinib for patients with myelofibrosis: 5-year update from the randomized, double-blind, placebo-controlled, phase 3 COMFORT-I trial [PDF]

, 2017
DiPersio, John F, et al,
core   +1 more source

Predictors of systemic sclerosis patients with interstitial lung disease progression: A retrospective study

Rheumatology &Autoimmunity, EarlyView.
The final systemic sclerosis patients with interstitial lung disease (SSc‐ILD) progression prediction model was composed of 6 significant risk factors: male, type 2 diabetes mellitus, pericardial effusion, anti‐Ro52, hypoproteinemia, and elevated C‐reactive protein. Our model demonstrated excellent prognostic utility.
Xi Cao, Shanshan Wang, Wenyi Yuan, Mian Liu, Xiaoyan Xin, Xiang Fang, Dandan Wang   +6 more
wiley   +1 more source

Distinguishing Hemophagocytic Lymphohistiocytosis, Immune Reconstitution Inflammatory Syndrome, and HIV-Associated Immune Thrombocytopenic Purpura: A Challenging Case of Thrombocytopenia in AIDS. [PDF]

Cureus
Khan M, Ansari AZ, Lief S, Tirumalareddy RR, Gudigopuram SVR, Lichtenberg AB, Choudhury SA, Gandara HA, Ali R.   +8 more
europepmc   +1 more source

Low-molecular-weight heparin-induced thrombocytopenia with multisite embolism: successful management with argatroban and dabigatran - a case report and literature review. [PDF]

Front Pharmacol
Zhao H, Tang X, Song X.
europepmc   +1 more source

Thrombosis or Myocardial Infarction in Congenital Clotting Factor Abnormalities and Chronic Thrombocytopenias

, 1983
Lawrence T. Goodnough, Hidehiko Saito, Oscar D. Ratnoff   +2 more
openalex   +1 more source