Results 51 to 60 of about 78,032 (168)

Pediatric thrombotic thrombocytopenic purpura

European Journal of Haematology, 2018
Child‐onset thrombotic thrombocytopenic purpura (TTP) is a rare entity of thrombotic microangiopathy (TMA). The pathophysiology of the disease is based on a severe functional deficiency of ADAMTS13 (activity
B. Joly, P. Coppo, A. Veyradier
semanticscholar   +1 more source

A clinical case of thrombocytopenic purpura in a 13-year-old child

Лечащий Врач
Background. Immune thrombocytopenic purpura is an immune-mediated disease that develops as a result of impaired immune tolerance to platelet antigens and the formation of antibodies to them, followed by a decrease in platelet levels per unit volume of ...
A. Yu. Babko, O. B. Gordeeva, A. V. Dobrotok   +2 more
doaj   +1 more source

FIGO guideline on liver disease and pregnancy

International Journal of Gynecology &Obstetrics, Volume 170, Issue 1, Page 28-48, July 2025.
Abstract The number of women entering pregnancy with chronic liver disease is rising. Gestational liver disorders affect 3% of the pregnant population. Both can be associated with significant maternal and fetal morbidity and mortality. European guidance has recently been published to inform management.
Melanie Nana, Virna Medina, Cynthia Maxwell, Ciara McCormick, Gloria Taliani, Ulrich Beuers, Deborah Money, Bo Jacobsson, Anil Kapur, Titus Beyuo, Francisco Ruiloba, Graeme Smith, Lina Bergman, Sharleen O'Reilly, Patrick O'Brien, Mark Hanson, Mary Rosser, Claudio Sosa, Sumaiya Adam, Valerie Guinto, Liona Poon, Fionnuala McAuliffe, Catherine Williamson, on behalf of the FIGO Committee on Impact of Pregnancy on Long‐term Health, FIGO Committee on Infections during Pregnancy and the FIGO Division of Maternal and Newborn Health   +24 more
wiley   +1 more source

Primary Cerebral Venous Thrombosis in a Patient with Immune Thrombocytopenic Purpura

Case Reports in Neurological Medicine, 2022
Introduction. Immune thrombocytopenic purpura is an autoimmune hematological disorder characterized by low platelet level due to its destruction through autoimmune antibodies.
M. Taher Farfouti, Christina Masri, Mike Ghabally, George Roumieh   +3 more
doaj   +1 more source

Pathophysiology of thrombotic thrombocytopenic purpura.

Blood, 2017
The discovery of a disintegrin-like and metalloproteinase with thrombospondin type 1 motif, member 13 (ADAMTS13) revolutionized our approach to thrombotic thrombocytopenic purpura (TTP).
J. E. Sadler
semanticscholar   +1 more source

Utility and Safety of Romiplostim as an Alternative to Platelet Transfusion for Neonates

Pediatric Blood &Cancer, Volume 72, Issue 7, July 2025.
ABSTRACT Thrombocytopenia is a common challenge in the neonatal intensive care unit, traditionally managed with platelet transfusions. However, transfusions are associated with significant risks, including increased mortality and neurodevelopmental impairment.
Rachel N. Zeno, Sara Awad, Harry Lesmana
wiley   +1 more source

Rare Presentation of Refractory Thrombotic Thrombocytopenic Purpura: Jejunal Stricture

International Journal of Hematology-Oncology and Stem Cell Research, 2017
Thrombotic thrombocytopenic purpura is a rare thrombotic disease characterized by episodes of thrombocytopenia and microangiopathic hemolytic anemia due to disseminated microvascular thrombosis.
Prabath K. Abeysundara, Inoshi Atukorala, K. P. C. Dalpatadu, Karthiha Balendran, M. D. S. A. Dilrukshi, G M O Fernando   +5 more
doaj  

Ventilation/perfusion SPECT in children: Feasibility, impact on clinical decision‐making and interrater agreement

Clinical Physiology and Functional Imaging, Volume 45, Issue 4, July 2025.
Abstract Introduction It remains to be established whether it provides any clinical or diagnostic benefits to perform ventilation/perfusion (V/Q) scintigraphy as a single photon emission computed tomography in children. Here, we report our experience with this modality, evaluate its impact on clinical decision‐making and assess its interrater agreement.
Lise Borgwardt, Mette Louise Mørk, Henrik Gutte, Anne Kiil Berthelsen, Robin de Nijs, Ronan M. G. Berg, Jann Mortensen   +6 more
wiley   +1 more source

Rational Design of Single‐Domain Antibodies Targeting the Central Nervous System Neurite Outgrowth Inhibitor Nogo‐A

Applied Research, Volume 4, Issue 3, June 2025.
The development of a nanobody for Nogo‐A, a potent neurite outgrowth inhibitor crucial in multiple sclerosis, is reported using a rational design approach. The nanobody targets the Nogo‐A ectodomain at the S1PR2 receptor‐binding region with submicromolar KD.
Vaidehi Roy Chowdhury, Alexander Röntgen, Matthew Greenig, Yanira Méndez Gómez, Sebastian P. Spiegel, Magdalena Nowinska, Aubin Ramon, Pietro Sormanni, Andrew Chan, Michele Vendruscolo   +9 more
wiley   +1 more source

Caplacizumab reduces the frequency of major thromboembolic events, exacerbations and death in patients with acquired thrombotic thrombocytopenic purpura

Journal of Thrombosis and Haemostasis, 2017
Essentials Acquired thrombotic thrombocytopenic purpura (aTTP) is linked with significant morbidity/mortality. Caplacizumab's effect on major thromboembolic (TE) events, exacerbations and death was studied. Fewer caplacizumab‐treated patients had a major
F. Peyvandi, M. Scully, J. A. Hovinga, P. Knöbl, S. Cataland, K. D. Beuf, F. Callewaert, H. Winter, R. Zeldin   +8 more
semanticscholar   +1 more source