Results 81 to 90 of about 78,032 (168)

Antibodies to von Willebrand factor-cleaving protease in acute thrombotic thrombocytopenic purpura.

New England Journal of Medicine, 1998
BACKGROUND Thrombotic thrombocytopenic purpura is a potentially fatal disease characterized by widespread platelet thrombi in the microcirculation. In the normal circulation, von Willebrand factor is cleaved by a plasma protease.
H. Tsai, E. Lian
semanticscholar   +1 more source

Platelet count response to Helicobacter pylori eradication for idiopathic thrombocytopenic purpura in northeastern Brazil

Hematology, Transfusion and Cell Therapy, 2018
Background: Several studies have demonstrated that platelet counts in Helicobacter pylori-positive patients with chronic idiopathic thrombocytopenic purpura improved significantly after successful eradication of the infection.
Alzira Maria de Castro Barbosa, Rosangela Albuquerque Ribeiro, Cícero Ígor Simões Moura Silva, Francisco Will Saraiva Cruz, Orleancio Gomes Ripardo de Azevedo, Maria Helena da Silva Pitombeira, Lucia Libanez Campelo Braga   +6 more
doaj  

Involvement of the ADAMTS13–von Willebrand factor axis in acute kidney injury in mice with liver cirrhosis

Hepatology Research, Volume 55, Issue 6, Page 844-858, June 2025.
Abstract Aim Hepatorenal syndrome‐induced acute kidney injury (AKI) comprises AKI and liver cirrhosis (LC) and is a risk factor for poor prognoses of patients with LC. Decreased a disintegrin‐like metalloproteinase with thrombospondin type 1 motif 13 (ADAMTS13) activity and increased von Willebrand factor (vWF) antigen levels are associated with LC ...
Masayoshi Takami, Norihisa Nishimura, Kosuke Kaji, Nobuyuki Yorioka, Hiroyuki Masuda, Hiroaki Takaya, Koh Kitagawa, Shinya Sato, Tadashi Namisaki, Hitoshi Yoshiji   +9 more
wiley   +1 more source

The clinical use of platelet transfusions: A systematic literature review and meta‐analysis on behalf of the International Collaboration for Transfusion Medicine Guidelines

Transfusion, Volume 65, Issue 6, Page 1155-1169, June 2025.
Abstract Background Platelets are frequently transfused, but supply and potential harms highlight the importance of appropriate use. Study Design and Methods Our systematic review (SR) followed a predefined protocol. Eligible studies included SRs, randomized controlled trials (RCTs), and matched cohort observational studies between 1946 and March 2025.
Rachel Jug, Ursula La Rocca, Arwa Z. Al‐Riyami, Aarti Bathla, Ryan A. Metcalf, Sandra K. White, Simon J. Stanworth, Susan Nahirniak   +7 more
wiley   +1 more source

Improvement of thrombocytopenia after treatment for Helicobacter pylori in a patient with immunologic thrombocytopenic purpura

Revista Brasileira de Hematologia e Hemoterapia, 2014
Immune thrombocytopenic purpura is the most common autoimmune hematologic disease, affecting individuals of different ages. Recently, the bacterium Helicobacter pylori entered the list of causes of immune thrombocytopenic purpura.
Aline Maia Rocha, Luís Fábio Barbosa Botelho, David Maia Rocha   +2 more
doaj   +1 more source

Idiopathic thrombocytopenic purpura: a practice guideline developed by explicit methods for the American Society of Hematology.

Blood, 1996
DIOPATHIC thrombocytopenic purpura (ITP, also I known as primary immune thrombocytopenic purpura) is a hematologic disorder for which appropriate diagnostic and treatment strategies are uncertain.
J. George, S. Woolf, G. Raskob, J. Wasser, L. Aledort, P. Ballem, V. Blanchette, J. Bussel, D. Cines, J. Kelton, A. Lichtin, R. Mcmillan, J. Okerbloom, D. H. Regan, I. Warrier   +14 more
semanticscholar   +1 more source

ADAMTS13 and von Willebrand factor in thrombotic thrombocytopenic purpura.

Annual Review of Medicine, 2015
Pathogenesis of thrombotic thrombocytopenic purpura (TTP) was a mystery for over half a century until the discovery of ADAMTS13. ADAMTS13 is primarily synthesized in the liver, and its main function is to cleave von Willebrand factor (VWF) anchored on ...
X. Zheng
semanticscholar   +1 more source

How I treat refractory thrombotic thrombocytopenic purpura.

Blood, 2015
Acquired thrombotic thrombocytopenic purpura (TTP) is characterized by thrombocytopenia and microangiopathic hemolytic anemia (MAHA) without an obvious cause, and may include fever, mild renal failure, and neurologic deficits.
F. Sayani, C. Abrams
semanticscholar   +1 more source

Acute Kidney Injury, Immune Thrombocytopenic Purpura, and the Infection That Binds Them Together: Disseminated Histoplasmosis

Journal of Investigative Medicine High Impact Case Reports, 2017
Untreated human immunodeficiency virus (HIV) can be complicated by opportunistic infections, including disseminated histoplasmosis (DH). Although endemic to portions of the United States and usually benign, DH can rarely act as an opportunistic infection
Pooja Sethi MD, Jennifer Treece MD, MBA, Chidinma Onweni MD, Vandana Pai MD, Sowminya Arikapudi MD, Lakshmi Kallur MD, Varun Kohli MD, Jonathan Moorman MD, PhD, FACP   +7 more
doaj   +1 more source

Thrombocytopenia: diagnosis with flow cytometry and antiplatelet antibodies

Einstein (São Paulo), 2011
Objective: To identify antiplatelet antibodies by flow cytometry (direct method) in patients with thrombocytopenia. Methods: Between January 1997 and March 2004 a total of 15100 patients were referred to the Centro de Hematologia de São Paulo for ...
João Carlos de Campos Guerra, Ruth Hissae Kanayama, Sonia Tsukasa Nozawa, Márcia Regina Ioshida, Irina Yoko Takiri, Robson José Lazaro, Nelson Hamerschlak, Luiz Gastão Mange Rosenfeld, Celso Carlos de Campos Guerra, Nydia Strachman Bacal   +9 more
doaj   +2 more sources