Results 41 to 50 of about 68,801 (240)

Evaluation of real-world use of pulmonary embolism thrombolysis: ERUPT

ERJ Open Research
Introduction International guidelines recommend systemic thrombolysis for high-risk acute pulmonary embolism (PE). Significant uncertainties remain regarding thrombolysis in non-high-risk PE and the use of reduced-dose thrombolysis.
Ruth Sobala, Joseph Kibbler, Kay Yip, Ross Thompson, Cecillia Rafique, Matthew Steward, Romit Samanta, Akhilesh Jha, Najib Rahman, Anthony De Soyza, INSPIRE ERUPT collaborators, Jonathan Ayling-Smith, Alexandra Dipper, Delia Dorrian, Frances Grudzinska, Jo Hardy, Thomas Jones, Joseph Kibbler, Lola Loewenthal, Victoria Randles, Alex Teagle, Shaun Thein, Aki Jha, Hannah Carlin, Charlotte Holland, Arun-Brahmanya Prasad, Syed Jawad Ahmad, Hussain Basheer, Katie Burke, Alison Carter, Roisin Connon, Kennedy Edwards, Nehemiah Edwards, Thomas Fretwell, Freddy Frost, Fern Galhighay, Anita Golash, Sushant Goyal, Bipima Gurung, David Henshall, James Hyman, Daniel Mitchell, Philip Jones, Ghulam Haider Khan, Leila Mohammadi, Sarmad Mushtaq, Iftikhar Nadeem, Oghenevwed Anderson Okuma, Alasdair Phillips, Ben Pippard, Kay Protheroe, Jonathan Quinn, Victoria Randles, Shiva Sathanandam, Amina Yousuf Shaikh, Vikram Singh, Krishna Sivakumaran, Wojciech Slusarczyk, Katherine Smethurst, Asmah Syed, Richard Thorley, Hazel Watchorn, David Wilkinson   +62 more
doaj   +1 more source

Magnetic Micro‐ and Nanorobots for Precision Thrombolysis: Design Strategies and Translational Challenges

Advanced Robotics Research, EarlyView.
Micro‐ and nanorobots for targeted thrombolysis. This perspective elaborates on the clinical indication of blood clot disorders and current limitations for treatment. As a novel, alternative solution, micro‐ and nanorobots can be used to treat and break down thrombi.
Joshua M. Mesfin, Yimo Yan, Nikola Cesarovic, Simone Schuerle   +3 more
wiley   +1 more source

COST-EFFECTIVENESS EVALUATION OF PREHOSPITAL THROMBOLYSIS WITH TENECTEPLASE

Рациональная фармакотерапия в кардиологии, 2016
Aim. To evaluate clinical and cost effectiveness of different reperfusion strategies in myocardial infarction with ST segment elevation (STEMI), including pre-hospital thrombolysis with tenecteplase.  Material and methods.
V. V. Omel'yanovskiy, E. V. Derkach, P. M. Khaylov, S. N. Tereshchenko   +3 more
doaj   +3 more sources

Intelligent Micro/Nanorobots for Targeted Interventional Therapy: From Bench to Clinic

Advanced Robotics Research, EarlyView.
Zirui Zhang et al. reviewed the application and challenges of mobile nanomachines in interventional therapy. By converting exogenous energy, including chemical, magnetic, optical, and ultrasonic sources, into mechanical forces, micro/nanorobots (MNRs) enable precise actuation at unprecedented scales. Evolving far beyond traditional drug delivery, these
Zirui Zhang, Yu Dong, Yongsheng Du, Rui Gao, Lin Zhang, Fei Tong   +5 more
wiley   +1 more source

Coronary Thrombolysis

Chest, 1989
Cairns, J, Collins, R, Fuster, V, Passamani, E   +3 more
  +9 more sources

Intravenous thrombolytic therapy for acute ischemic stroke in Hubei, China: a survey of thrombolysis rate and barriers

BMC Neurology, 2019
Background Rates of thrombolysis in most countries are well below best practice benchmarks. We aimed to investigate thrombolysis utilization and its associated factors in acute ischemic stroke (AIS) patients in Hubei province, China, to assess ...
Yanfeng Zhou, Shijiao Yan, Xingyue Song, Yanhong Gong, Wenzhen Li, Mengdie Wang, Xiaoxv Yin, Bo Hu, Zuxun Lu   +8 more
doaj   +1 more source

Cell‐Based Biohybrid Micro/Nanorobots for Biotherapy

Advanced Robotics Research, EarlyView.
This review systematically evaluates cell‐based biohybrid micro/nanorobots (CB‐BMRs), highlighting their cell selection criteria, fabrication strategies, and diverse actuation modes. Furthermore, it surveys the promising therapeutic applications of CB‐BMRs in targeted cancer, thrombosis, and inflammation treatments, while comprehensively discussing ...
Lin Wang, Chenlu Liu, Yu Zhao, Chuanhua Li, Xuyang Chen, Shixiao Ding, Lizhou Dai, Guokun Wang, Tianlong Li, Jiaxin Li, Xuejia Liu, Haocheng Wang   +11 more
wiley   +1 more source

Astrocytic LMP2 Coordinates NF‐κB and TGF‐β1/Smad3 Signaling to Drive Neuroinflammation after Cerebral Ischemia/Reperfusion

Advanced Science, EarlyView.
ABSTRACT Astrocyte reactivity critically shapes neuroinflammatory outcomes after ischemic stroke, yet the upstream regulators governing astrocyte state transitions remain incompletely defined. Here, we identify the immunoproteasome subunit low molecular weight protein 2 (LMP2) as an important modulator of astrocyte functional remodeling following ...
Yanguang Mao, Rulan Ma, Zejing Lin, Huiying Zhao, Yuexian Liu, Yonghe Su, Xu Zhang, Xingyong Chen   +7 more
wiley   +1 more source

Association between the atherogenic index of plasma and the non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio with early neurological deterioration after thrombolysis

Frontiers in Neurology
BackgroundThe atherogenic index of plasma (AIP) and non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) are newly developed markers of lipid and glucose metabolism.
Yan Jiang, Mingzhu Deng, Kangping Song, Zhen Wang, Wei Xu, Tieqiao Feng, Sufen Chen, Can Wan, Xiugui Ma, Fangyi Li   +9 more
doaj   +1 more source

Engineered Brain‐Targeted Exosomes Delivering FGF1 for Sustained Glycemic Regulation and Multitarget Neurovascular Protection in Diabetic Stroke

Advanced Science, EarlyView.
ABSTRACT Diabetic stroke is characterized by a hyperglycemic and pro‐inflammatory microenvironment that exacerbates neurovascular dysfunction. However, the blood–brain barrier (BBB) remains a formidable obstacle, restricting the delivery of most therapeutic molecules.
Bixin Shen, Chengxiang Zhang, Junhui Wang, Xichong Zhong, Shihao Chen, Xue Wang, Xiaokun Li, Li Lin   +7 more
wiley   +1 more source