Results 111 to 120 of about 2,550,374 (236)

Design, Synthesis of 3‐n‐Butylphthalide‐Hydrazine/Hydrazide Derivatives as Potential Anti‐Ischemic Stroke Agents

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
A series of 3‐n‐butylphthalide hydrazine and hydrazide hybrids were synthesized. Among them, NBP‐HY exhibited superior antiplatelet activity compared to both NBP and aspirin. In vivo experiments confirmed that NBP‐HY possesses potent antithrombotic and anti‐ischemic stroke efficacy, coupled with moderate metabolic stability, favorable blood–brain ...
Yong Li, Manju Wang, Qing Zhang, Pengfei Zhou, Ya Yang, Lei Tang, Judi Fan, Lingling Fan   +7 more
wiley   +1 more source

Evaluation of Contraindication of Thrombolytic Therapy and Its Causes after AMI in Hamadan Ekbatan Hospital in 2002

پزشکی بالینی ابن سینا, 2005
Acute myocardial infarction (AMI ) is one of the most common cause of mortality in almost all countries of the world. According to this fact that thrombus formation and coronary obstruction are the basic pathophysiology of AMI , early    thrombolysis and
Shahram Homayonfar, Amin Bahreini, Morteza Jalilvand   +2 more
doaj  

Drug‐Coated Balloon‐Based Strategy for De Novo Coronary Artery Disease Across Complex and High‐Risk Indicated Percutaneous Coronary Intervention Risk Categories: A Multicenter Registry Study

Catheterization and Cardiovascular Interventions, Volume 108, Issue 4, Page 1124-1134, October 1, 2026.
ABSTRACT Background Evidence regarding the risk‐stratified effectiveness of drug‐coated balloon (DCB)‐based PCI for de novo coronary artery disease (CAD) remains limited, particularly in patients undergoing complex and high‐risk indicated percutaneous coronary intervention (CHIP PCI).
Dong Oh Kang, Sunwon Kim, Ae‐Young Her, Eun‐Seok Shin   +3 more
wiley   +1 more source

Local and systemic thrombolytic therapy for acute deep venous thrombosis. [PDF]

, 2005
Contains fulltext : 48677.pdf (Publisher’s version ) (Open Access)This article presents a review of the treatment of lower-extremity deep venous thrombosis (DVT) with systemic and catheter-directed thrombolysis (CDT) and percutaneous ...
Janssen, M.C.H., Wollersheim, H.C.H., Schultze Kool, L.J., Thien, Th.   +3 more
core  

How to Avoid Misdiagnosing Primary Spinal Epidural Abscess as Spinal Epidural Hematoma: A Case Report and Literature Review

Clinical Case Reports, Volume 14, Issue 10, October 2026.
ABSTRACT Spinal epidural abscess (SEA) is an easily misdiagnosed disease. We report a case of primary SEA (PSEA) that was misdiagnosed as spinal epidural hematoma (SEH) and analyze the reasons. The misdiagnosis was confirmed intraoperatively. Comprehensive analysis is crucial for the diagnosis of PSEA and its differential diagnosis from SEH.
Sheng‐Wei Meng, Qian Liu, Yong‐Sheng Zhao   +2 more
wiley   +1 more source

An Early Longitudinal Decrease in Platelet Count Is Associated With Poor Prognosis in Acute Myocardial Infarction Patients: A Multicenter Retrospective Study

Clinical Cardiology, Volume 49, Issue 10, October 2026.
ICU 28‐day all‐cause mortality was 6.1% (410/6769). During the first 5 days, platelet counts were significantly lower in ICU 28‐day non‐survivors than in survivors. The difference in platelet counts between ICU 28‐day non‐survivors and survivors increased by an average of 15.4 × 109/L daily (95% CI, 14.1 to 16.7).
Tianlai Lin, Jingqing Xu, Xiaoling Zeng, Qiang Liu, Mouying Liu, Xizhe Chen, Youli Chen   +6 more
wiley   +1 more source

Adeno‐Associated Virus Vector‐Mediated Expression of Neuroligin 2 in the Mouse Hippocampus Attenuates the Progression of Pentylenetetrazol‐Induced Seizures

The Journal of Gene Medicine, Volume 28, Issue 10, October 2026.
Mice received bilateral hippocampal injections of an AAV vector expressing NL2, followed by repeated PTZ administration. NL2 expression in the HPC attenuated seizure progression and reduced c‐Fos expression in the ventral HPC. These findings suggest that AAV‐mediated NL2 expression in the HPC may be a potential therapeutic strategy for seizure control.
Tomohiro Tokutake, Akane Hara, Ayano Murayama, Yuto Mitsuda, Jun Yokose, Yusuke Yano, Yuki Shigetsura, Mika Ito, Naomi Takino, Shinichi Kumagai, Kuniko Shimazaki, Shin‐Ichi Muramatsu, Atsumi Nitta   +12 more
wiley   +1 more source

A Novel GDF2 Mutation in a Patient With Hereditary Hemorrhagic Telangiectasia Complicated by Acute Cerebral Infarction

eJHaem, Volume 7, Issue 5, October 2026.
ABSTRACT Introduction Hereditary hemorrhagic telangiectasia (HHT) is an autosomal dominant disease and the growth differentiation factor 2 (GDF2) variants have been identified as an infrequent cause of HHT. Case Report We report a 64‐year‐old female patient with an onset of ischemic stroke suspected related with microscopic pulmonary arteriovenous ...
Huaqin Zuo, Lingling Qian, Jian Jing, Lu Wang, Xiaobo Li, Yong Chen, Xuefeng Wang, Qiulan Ding, Jian Gu, Mei Sun   +9 more
wiley   +1 more source

Early Dapagliflozin and Melatonin Treatment Ameliorated LV Fibrosis via Suppressing TGF‐β1/Smads and Activating Nrf2‐ARE Signaling in MI Rodent

The Kaohsiung Journal of Medical Sciences, Volume 42, Issue 10, October 2026.
ABSTRACT This study tested whether combined dapagliflozin (DAPA) and melatonin (Mel) therapy was superior to merely one for ameliorating the left ventricular (LV) fibrosis/remodeling and improving LV ejection fraction (LVEF) in rats after acute myocardial infarction (AMI). In vitro study demonstrated that DAPA treatment significantly suppressed the TGF‐
Jiunn‐Jye Sheu, Jui‐Ning Yeh, Han‐Tan Chai, John Y. Chiang, Chi‐Ruei Huang, Jun Guo, Hon‐Kan Yip   +6 more
wiley   +1 more source

Thrombolytic therapy in acute ischemic stroke. A Danish pilot study.

, 1993
In a feasibility and safety study of thrombolytic therapy in acute ischemic stroke, we explored the usefulness of measurements of regional cerebral blood flow.
T S Olsen, B Sperling, G Boysen, K Ellemann, A Karle, H Pedersen, P Arlien-Søborg, C Videbaek, K Overgaard, J Gam   +9 more
core   +1 more source