The unbearable lightness of bone marrow homeostasis [PDF]
, 2015 The anatomical and functional dimensions of bone marrow topography have been at the forefront of modern bone and immunological research for many years and remain a source of complexity and perplexity due to the multitude of microhabitats within this ...
AGAS, DIMITRIOS +3 more
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CD11c+ Cells Control Platelet Homeostasis in a Murine Bone Marrow Chimeric Atherosclerosis Model
BiomedicinesBackground/Objectives: Dendritic cells (DCs) are key regulators of immune responses in cardiovascular disease, yet their role in platelet homeostasis and thrombopoiesis remains incompletely understood. We previously demonstrated that chronic depletion of
Manuela Sauter +3 more
doaj +1 more source
Increased mean platelet volume in type 2 diabetes mellitus [PDF]
, 2014 Objective: Platelet functions have important roles in the development of vascular complications in diabetic patients. Platelets with increased volume have increased activity compared to smaller ones; therefore, mean platelet volume (MPV) is used as a ...
Ahmet Hondur +4 more
core +1 more source
Autoantibody-mediated desialylation impairs human thrombopoiesis and platelet lifespan
Haematologica, 2019 Immune thrombocytopenia is a common bleeding disease caused by autoantibody-mediated accelerated platelet clearance and impaired thrombopoiesis. Accumulating evidence suggests that desialylation affects platelet life span in immune thrombocytopenia ...
Irene Marini +8 more
doaj +1 more source
Transit times through the cycle phases of jejunal crypt cells of the mouse [PDF]
, 1979 Mean transit times as well as variances of the transit times through the individual phases of the cell cycle have been determined for the crypt epithelial cells of the jejunum of the mouse. To achieve this the fraction of labelled mitoses (FLM) technique
Kellerer, Albrecht M. +2 more
core
Molecular heterogeneity in AML/MDS patients with 3q21q26 rearrangements [PDF]
, 2004 Patients with 3q21q26 rearrangements seem to share similar clinicopathologic features and a common molecular mechanism, leading to myelodysplasia or acute myeloid leukemia (AML).
Barjesteh van Waalwijk van Doorn-Khosrovani +47 more
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Modeling individual time courses of thrombopoiesis during multi-cyclic chemotherapy.
PLoS Computational Biology, 2019 BACKGROUND:Thrombocytopenia is a major side-effect of cytotoxic cancer therapies. The aim of precision medicine is to develop therapy modifications accounting for the individual's risk.
Yuri Kheifetz, Markus Scholz
doaj +1 more source
Salicylate Inhibits Thrombopoiesis in Rat Megakaryocytes by Changing the Membrane Micro-Architecture
Cellular Physiology and Biochemistry, 2015 Background/Aims: Salicylate causes drug-induced immune thrombocytopenia. However, some clinical studies indicate the presence of additional mechanisms in the drug-induced thrombocytopenia, by which the platelet production from megakaryocytes may directly
Itsuro Kazama +6 more
doaj +1 more source
Racial Differences in the Effect of Granulocyte Macrophage Colony-Stimulating Factor on Improved Walking Distance in Peripheral Artery Disease: The PROPEL Randomized Clinical Trial. [PDF]
, 2019 Background The effects of race on response to medical therapy in people with peripheral artery disease ( PAD ) are unknown. Methods and Results In the PROPEL (Progenitor Cell Release Plus Exercise to Improve Functional Performance in PAD) Trial, PAD ...
Criqui, Michael H +11 more
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Human thrombopoiesis depends on Protein kinase Cδ/protein kinase Cε functional couple
Haematologica, 2016 A deeper understanding of the molecular events driving megakaryocytopoiesis and thrombopoiesis is essential to regulate in vitro and in vivo platelet production for clinical applications.
Cecilia Carubbi +8 more
doaj +1 more source