Results 1 to 10 of about 4,313 (132)

M2 macrophages, but not M1 macrophages, support megakaryopoiesis by upregulating PI3K-AKT pathway activity

Signal Transduction and Targeted Therapy, 2021
Dysfunctional megakaryopoiesis hampers platelet production, which is closely associated with thrombocytopenia (PT). Macrophages (MФs) are crucial cellular components in the bone marrow (BM) microenvironment.
Hong-Yan Zhao, Zhong-Shi Lyu, Meng Lv
exaly   +2 more sources

CSF1R modulates megakaryopoiesis by targeting RUNX1 in immune thrombocytopenia [PDF]

Haematologica
Immune thrombocytopenia (ITP) is an autoimmune bleeding disorder characterized by platelet destruction and defective megakaryopoiesis. However, the mechanisms underlying megakaryocyte (MK) dysfunction in ITP remain unclear. To address this, we performed
Haohao Han, Meng Zhou, Jiaqian Qi, Xiaofei Song, Xueqian Li, Ziyan Zhang, Tingting Pan, Xiaoyan Xu, Mengting Guo, Depei Wu, Yue Han   +10 more
doaj   +2 more sources

MEIS1 Regulates Hemogenic Endothelial Generation, Megakaryopoiesis, and Thrombopoiesis in Human Pluripotent Stem Cells by Targeting TAL1 and FLI1

Stem Cell Reports, 2018
Summary: Human pluripotent stem cells (hPSCs) provide an unlimited source for generating various kinds of functional blood cells. However, efficient strategies for generating large-scale functional blood cells from hPSCs are still lacking, and the ...
Mengge Wang, Jie Gao, Pei Su
exaly   +3 more sources

Rapamycin and bafilomycin A1 alter autophagy and megakaryopoiesis

Platelets, 2017
Autophagy is an effective strategy for cell development by recycling cytoplasmic constituents. Genetic deletion of autophagy mediator Atg7 in hematopoietic stem cells (HSCs) can lead to failure of megakaryopoiesis and enhanced autophagy has been ...
Tao You, Hongqiong Fan, Yinyan Wang
exaly   +2 more sources

Heterozygous nonsense FLI1 p.Met100∗ variant results in thrombocytopenia and increased erythroid gene expression [PDF]

Research and Practice in Thrombosis and Haemostasis
Background: Megakaryocytes and platelets arise from hematopoietic stem and progenitor cells through a tightly regulated process involving various transcription factors, including erythroblast transformation–specific family member FLI1.
Huan Zhang, Elise J. Huisman, Roel van Rhijn, Arthur F. Svendsen, Hans Janssen, Nicole van der Wel, Carmen van der Zwaan, Nynke Gillemans, Wilfred F.J. van IJcken, Marten Hansen, Marjon H. Cnossen, Sjaak Philipsen, Arie J. Hoogendijk, Emile van den Akker, Martijn Brands, Sjoerd Koopman, Laura Bukkems, Michael Cloesmeijer, Alexander Janssen, Karin Fijnvandraat, Samantha Gouw, Ron Mathôt, Maartje van den Biggelaar, Sander Meijer, Jan Voorberg, Jessica Del Castillo Alferez, Karina Meijer, Jeroen Eikenboom, Sebastiaan Laan, Ruben Bierings, Marjon Cnossen, Masja de Haas, Frank Leebeek, Hester Lingsma, Moniek de Maat, Iris van Moort, Simone Reitsma, Ryanne Arisz, Lorenzo Romano, Wala Al Arashi, Shannon van Hoorn, Tine Goedhart, Caroline Mussert, Diaz Prameyllawati, Rolf Urbanus, Minka Zivkovic, Annelien Bredenoord, Rieke van der Graaf, Lieke Baas, Roger Schutgens   +49 more
doaj   +2 more sources

Temporal Lysophosphatidic Acid Supplementation Enhances Megakaryocyte Differentiation and Platelet Production From Human Hematopoietic Progenitors. [PDF]

Cell Biol Int
ABSTRACT Platelet shortages and limited storage stability restrict global platelet transfusion capacity, highlighting the need for efficient in vitro platelet production systems. This study establishes a simple, non‐genetic and cost‐effective system for efficient in vitro platelet‐like particle (PLP) production from human hematopoietic stem/progenitor ...
Jiamvoraphong N, Lorthongpanich C, Septham P, Klaihmon P, Kheolamai P, Laowtammathron C, Imsoonthornruksa S, Ketudat-Cairns M, Issaragrisil S.   +8 more
europepmc   +2 more sources

Induction of moderate DNA damage enhances megakaryopoiesis and platelet production [PDF]

Blood Advances
: Megakaryocytes (MKs) are large, hematopoietic cells with a polyploid, multilobulated nucleus. Although DNA replication in MKs (endomitosis) is well studied, limited investigations have examined the impact of DNA instability on megakaryopoiesis.
Virginia Camacho, Roelof H. Bekendam, Andrew P. Stone, Maria N. Barrachina, Siobhan Branfield, Estelle Carminita, Isabelle C. Becker, Dong H. Lee, Ethan Walsey, Clementine Payne, Jakub Kaplan, Julia Tilburg, Sharmistha Pal, Luis Francisco Zirnberger Batista, Joseph E. Italiano, Jr., Kellie R. Machlus   +15 more
doaj   +2 more sources

CXCR4high megakaryocytes regulate host-defense immunity against bacterial pathogens

eLife, 2022
Megakaryocytes (MKs) continuously produce platelets to support hemostasis and form a niche for hematopoietic stem cell maintenance in the bone marrow.
Jin Wang, Jiayi Xie, Daosong Wang, Xue Han, Minqi Chen, Guojun Shi, Linjia Jiang, Meng Zhao   +7 more
doaj   +1 more source

Replication of Dengue Virus in K562-Megakaryocytes Induces Suppression in the Accumulation of Reactive Oxygen Species

Frontiers in Microbiology, 2022
Dengue virus can infect human megakaryocytes leading to decreased platelet biogenesis. In this article, we report a study of Dengue replication in human K562 cells undergoing PMA-induced differentiation into megakaryocytes. PMA-induced differentiation in
Jaskaran Kaur, Yogita Rawat, Vikas Sood, Neha Periwal, Deepak Kumar Rathore, Shrikant Kumar, Niraj Kumar, Sankar Bhattacharyya   +7 more
doaj   +1 more source

Expression of ADP receptor P2Y12, thromboxane A2 receptor and C-type lectin-like receptor 2 in cord blood-derived megakaryopoiesis

Platelets, 2021
The ADP receptor P2Y12, the thromboxane A2 receptor (TXA2R) and the C-type lectin-like receptor 2 (CLEC-2) mediate platelet activation by different mechanisms. Only little is known about the expression of the receptors in human megakaryopoiesis.
Catharina Gerhards, Stefanie Uhlig, Mani Etemad, Foteini Christodoulou, Karen Bieback, Harald Klüter, Peter Bugert   +6 more
doaj   +1 more source