Results 1 to 10 of about 4,378 (155)

TFII-I/Gtf2i and Erythro-Megakaryopoiesis [PDF]

Frontiers in Physiology, 2020
TFII-I is a ubiquitously expressed transcription factor that positively or negatively regulates gene expression. TFII-I has been implicated in neuronal and immunologic diseases as well as in thymic epithelial cancer.
Zhijian Qian, Marjorie Brand, John Strouboulis   +2 more
exaly   +6 more sources

Role of Rho-GTPases in megakaryopoiesis [PDF]

Small GTPases, 2021
Megakaryocytes (MKs) are the bone marrow (BM) cells that generate blood platelets by a process that requires: i) polyploidization responsible for the increased MK size and ii) cytoplasmic organization leading to extension of long pseudopods, called proplatelets, through the endothelial barrier to allow platelet release into blood.
Hana Rašlová, William Vainchenker, Larissa Lordier   +2 more
exaly   +3 more sources

CSF1R modulates megakaryopoiesis by targeting RUNX1 in immune thrombocytopenia [PDF]

Haematologica
Immune thrombocytopenia (ITP) is an autoimmune bleeding disorder characterized by platelet destruction and defective megakaryopoiesis. However, the mechanisms underlying megakaryocyte (MK) dysfunction in ITP remain unclear. To address this, we performed
Haohao Han, Meng Zhou, Jiaqian Qi, Xiaofei Song, Xueqian Li, Ziyan Zhang, Tingting Pan, Xiaoyan Xu, Mengting Guo, Depei Wu, Yue Han   +10 more
doaj   +2 more sources

JMJD1C Regulates Megakaryopoiesis in In Vitro Models through the Actin Network

Cells, 2022
The histone demethylase JMJD1C is associated with human platelet counts. The JMJD1C knockout in zebrafish and mice leads to the ablation of megakaryocyte–erythroid lineage anemia.
Zhen Hu, Hu Zhenbo, Lili Qin
exaly   +3 more sources

Rapamycin and bafilomycin A1 alter autophagy and megakaryopoiesis

Platelets, 2017
Autophagy is an effective strategy for cell development by recycling cytoplasmic constituents. Genetic deletion of autophagy mediator Atg7 in hematopoietic stem cells (HSCs) can lead to failure of megakaryopoiesis and enhanced autophagy has been ...
Mortimer Poncz, Li Zhu, Hongqiong Fan
exaly   +2 more sources

In vitro effect of eltrombopag alone and in combination with azacitidine on megakaryopoiesis in patients with myelodysplastic syndrome

Platelets, 2021
Thrombocytopenia is a severe complication for patients with myelodysplastic syndrome (MDS). Eltrombopag increases platelet count in MDS patients but its combination with azacitidine elicited controversial results.
Marianna Criscuolo, Giulia Falconi, Livio Pagano   +2 more
exaly   +2 more sources

Heterozygous nonsense FLI1 p.Met100∗ variant results in thrombocytopenia and increased erythroid gene expression [PDF]

Research and Practice in Thrombosis and Haemostasis
Background: Megakaryocytes and platelets arise from hematopoietic stem and progenitor cells through a tightly regulated process involving various transcription factors, including erythroblast transformation–specific family member FLI1.
Huan Zhang, Elise J. Huisman, Roel van Rhijn, Arthur F. Svendsen, Hans Janssen, Nicole van der Wel, Carmen van der Zwaan, Nynke Gillemans, Wilfred F.J. van IJcken, Marten Hansen, Marjon H. Cnossen, Sjaak Philipsen, Arie J. Hoogendijk, Emile van den Akker, Martijn Brands, Sjoerd Koopman, Laura Bukkems, Michael Cloesmeijer, Alexander Janssen, Karin Fijnvandraat, Samantha Gouw, Ron Mathôt, Maartje van den Biggelaar, Sander Meijer, Jan Voorberg, Jessica Del Castillo Alferez, Karina Meijer, Jeroen Eikenboom, Sebastiaan Laan, Ruben Bierings, Marjon Cnossen, Masja de Haas, Frank Leebeek, Hester Lingsma, Moniek de Maat, Iris van Moort, Simone Reitsma, Ryanne Arisz, Lorenzo Romano, Wala Al Arashi, Shannon van Hoorn, Tine Goedhart, Caroline Mussert, Diaz Prameyllawati, Rolf Urbanus, Minka Zivkovic, Annelien Bredenoord, Rieke van der Graaf, Lieke Baas, Roger Schutgens   +49 more
doaj   +2 more sources

Direct megakaryopoiesis. [PDF]

Curr Opin Hematol
Purpose of review Megakaryocytes are large, polyploid cells that produce platelets and originate from hematopoietic stem cells (HSCs) in the bone marrow. While in the classical paradigm, megakaryocytes are generated in a stepwise fashion through increasingly committed progenitor stages, studies using in-vivo barcoding ...
Snoeck HW.
europepmc   +3 more sources

MEIS1 Regulates Hemogenic Endothelial Generation, Megakaryopoiesis, and Thrombopoiesis in Human Pluripotent Stem Cells by Targeting TAL1 and FLI1

Stem Cell Reports, 2018
Summary: Human pluripotent stem cells (hPSCs) provide an unlimited source for generating various kinds of functional blood cells. However, efficient strategies for generating large-scale functional blood cells from hPSCs are still lacking, and the ...
Lihong Shi, Mengge Wang, Jie Gao
exaly   +3 more sources

The Hippo-p53 pathway in megakaryopoiesis

Haematologica, 2016
Megakaryocytes are among the largest and rarest cells in the body, accounting for approximately 0.01% of nucleated cells in the bone marrow. Their differentiation involves a progression from hematopoietic stem cell to the megakaryocyte progenitor and finally to platelets.[1][1] A key step in ...
Praveen K Suraneni, John D. Crispino
doaj   +3 more sources