Results 1 to 10 of about 7,888 (191)
Signal Transduction and Targeted Therapy, 2021 Dysfunctional megakaryopoiesis hampers platelet production, which is closely associated with thrombocytopenia (PT). Macrophages (MФs) are crucial cellular components in the bone marrow (BM) microenvironment.
Yuan Kong, Meng Lv, Lan-Ping Xu
exaly +3 more sources
Induction of moderate DNA damage enhances megakaryopoiesis and platelet production. [PDF]
Blood AdvKey Points • Treatment of mice with low-dose PARP inhibitors or gamma irradiation enhances platelet counts.• Low-dose PARP inhibitor treatment and gamma irradiation increases DNA damage in MKs and MkPs and enhances megakaryopoiesis.
Camacho V +15 more
europepmc +3 more sources
Role of Rho-GTPases in megakaryopoiesis [PDF]
Small GTPases, 2021 Megakaryocytes (MKs) are the bone marrow (BM) cells that generate blood platelets by a process that requires: i) polyploidization responsible for the increased MK size and ii) cytoplasmic organization leading to extension of long pseudopods, called ...
Hana Raslova +2 more
exaly +4 more sources
Journal of Thrombosis and Haemostasis, 2023 BACKGROUND Germline mutations in the ETV6 transcription factor gene are responsible for familial thrombocytopenia and leukemia predisposition syndrome.
Falaise Celine +2 more
exaly +3 more sources
Differentiation route determines the functional outputs of adult megakaryopoiesis
ImmunityEmerging evidence has revealed a direct differentiation route from hematopoietic stem cells to megakaryocytes (direct route), in addition to the classical differentiation route through a series of restricted hematopoietic progenitors (stepwise route ...
Bo O Zhou, Qian-Fei Wang, Yueying Li
exaly +2 more sources
Mechanisms of Thrombocytosis in Iron-Deficiency Anemia. [PDF]
Eur J HaematolABSTRACT Iron‐deficiency anemia is frequently accompanied by reactive thrombocytosis, yet the mechanisms underlying this association remain incompletely understood. Beyond impaired erythropoiesis, iron availability has emerged as an active regulator of hematopoietic lineage decisions.
Facco JV, Krause DS, Olalla Saad ST.
europepmc +2 more sources
Investigator-Led Research to Improve the Diagnostic Assessment of Platelet Function Disorders: Reflections on the Challenges and Rewards. [PDF]
Int J Lab HematolABSTRACT Introduction Investigator‐led research and quality improvement initiatives have led to important improvements in the diagnostic assessment of platelet function disorders (PFD). Methods Personal reflections were used to summarize our contributions to knowledge on PFD diagnostic assessment, pathogenesis, and bleeding risks.
Hayward CPM.
europepmc +2 more sources
Dissecting Bone Marrow Fibrosis in Philadelphia-Negative Myeloproliferative Neoplasms: Multiple Roads Lead to Rome. [PDF]
Hematol OncolABSTRACT Philadelphia‐negative myeloproliferative neoplasms (MPN), a spectrum of blood malignancies characterized by uncontrolled myeloid proliferation, persist as a key challenge in onco‐hematology due to their intricate molecular background, heterogeneous clinical phenotypes, and variable prognoses.
Ballato M +8 more
europepmc +2 more sources
International Journal of Molecular Sciences, 2020 Megakaryopoiesis is the process during which megakaryoblasts differentiate to polyploid megakaryocytes that can subsequently shed thousands of platelets in the circulation. Megakaryocytes accumulate mRNA during their maturation, which is required for the
Marieke von Lindern +2 more
exaly +2 more sources
Nature Communications, 2023 Thrombocytopenia is a major complication in a subset of patients with multiple myeloma (MM). However, little is known about its development and significance during MM. Here, we show thrombocytopenia is linked to poor prognosis in MM.
Chun-Mei Kuang +20 more
semanticscholar +1 more source