Results 11 to 20 of about 7,888 (191)
Inside-to-outside and back to the future of megakaryopoiesis
Research and Practice in Thrombosis and Haemostasis, 2023 A State of the Art lecture titled “Megakaryocytes and different thrombopoietic environments” was presented at the ISTH Congress in 2022. Circulating platelets are specialized cells produced by megakaryocytes.
C. D. Di Buduo, C. Miguel, A. Balduini
semanticscholar +5 more sources
Normal and malignant megakaryopoiesis [PDF]
Expert Reviews in Molecular Medicine, 2011 Megakaryopoiesis is the process by which bone marrow progenitor cells develop into mature megakaryocytes (MKs), which in turn produce platelets required for normal haemostasis.
John D. Crispino +2 more
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Plasmacytoid dendritic cells control homeostasis of megakaryopoiesis [PDF]
NaturePlatelet homeostasis is essential for vascular integrity and immune defence1,2. Although the process of platelet formation by fragmenting megakaryocytes (MKs; thrombopoiesis) has been extensively studied, the cellular and molecular mechanisms required to
F. Gaertner +43 more
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Clinical & Experimental Thrombosis and Hemostasis, 2020 ing infused cells with small molecules to activate the signaling pathways involved in homing and survival or overexpression of antiapoptotic proteins may be one option.
Keiichi Tozawa +2 more
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JMJD1C Regulates Megakaryopoiesis in In Vitro Models through the Actin Network
Cells, 2022 The histone demethylase JMJD1C is associated with human platelet counts. The JMJD1C knockout in zebrafish and mice leads to the ablation of megakaryocyte–erythroid lineage anemia.
Jialing Wang +12 more
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Fetal versus adult megakaryopoiesis.
Blood, 2022 Fetal and neonatal megakaryocyte progenitors are hyperproliferative compared to adult progenitors, and generate large numbers of small, low ploidy megakaryocytes. Historically, these developmental differences were interpreted as "immaturity".
Patricia E. Davenport +2 more
semanticscholar +3 more sources
Thrombopoietic effect of VPAC1 inhibition during megakaryopoiesis [PDF]
British Journal of Haematology, 2010 International audienceMegakaryocytes and platelets express the stimulatory G protein (Gs)-coupled VPAC1 receptor, for which the pituitary adenylyl cyclase-activating peptide (PACAP) and vasoactive intestinal peptide (VIP) are agonists.
Stoffels, Katinka +13 more
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TFII-I/Gtf2i and Erythro-Megakaryopoiesis [PDF]
Frontiers in Physiology, 2020 TFII-I is a ubiquitously expressed transcription factor that positively or negatively regulates gene expression. TFII-I has been implicated in neuronal and immunologic diseases as well as in thymic epithelial cancer.
Wu, Qiong +9 more
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Studies on megakaryopoiesis and platelet function [PDF]
, 2015 Platelets are blood circulating specialized subcellular fragments, which are produced by megakaryocytes. Platelets are essential for hemostasis and wound healing but also play a role in non-hemostatic processes such as the immune response or cancer ...
Meinders, Marjolein, Meinders, M.
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Epigenetic regulation of megakaryopoiesis and platelet formation
HaematologicaPlatelets, produced by megakaryocytes, play unique roles in physiological processes, such as hemostasis, coagulation, and immune regulation, while also contributing to various clinical diseases.
Bai-Chuan Xu +4 more
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