Results 11 to 20 of about 4,363 (174)
TFII-I/Gtf2i and Erythro-Megakaryopoiesis [PDF]
Frontiers in Physiology, 2020 TFII-I is a ubiquitously expressed transcription factor that positively or negatively regulates gene expression. TFII-I has been implicated in neuronal and immunologic diseases as well as in thymic epithelial cancer.
Aishwarya Gurumurthy +9 more
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Epigenetic regulation of megakaryopoiesis and platelet formation
HaematologicaPlatelets, produced by megakaryocytes, play unique roles in physiological processes, such as hemostasis, coagulation, and immune regulation, while also contributing to various clinical diseases.
Baichuan Xu +4 more
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Normal and malignant megakaryopoiesis [PDF]
Expert Reviews in Molecular Medicine, 2011 Megakaryopoiesis is the process by which bone marrow progenitor cells develop into mature megakaryocytes (MKs), which in turn produce platelets required for normal haemostasis. Over the past decade, molecular mechanisms that contribute to MK development and differentiation have begun to be elucidated.
Qiang, Wen +2 more
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The Hippo-p53 pathway in megakaryopoiesis
Haematologica, 2016 Megakaryocytes are among the largest and rarest cells in the body, accounting for approximately 0.01% of nucleated cells in the bone marrow. Their differentiation involves a progression from hematopoietic stem cell to the megakaryocyte progenitor and finally to platelets.[1][1] A key step in ...
Praveen K Suraneni, John D. Crispino
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Direct megakaryopoiesis. [PDF]
Curr Opin HematolPurpose of review Megakaryocytes are large, polyploid cells that produce platelets and originate from hematopoietic stem cells (HSCs) in the bone marrow. While in the classical paradigm, megakaryocytes are generated in a stepwise fashion through increasingly committed progenitor stages, studies using in-vivo barcoding ...
Snoeck HW.
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JMJD1C Regulates Megakaryopoiesis in In Vitro Models through the Actin Network
Cells, 2022 The histone demethylase JMJD1C is associated with human platelet counts. The JMJD1C knockout in zebrafish and mice leads to the ablation of megakaryocyte–erythroid lineage anemia.
Jialing Wang +12 more
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Prognostic significance of mutated genes in megakaryocytic disorders
Oncology Reviews, 2019 Megakaryopoiesis is a process during which platelets that play a major role in hemostasis are produced due to differentiation and maturation of megakaryocytic precursors.
Ali Amin Asnafi +4 more
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Frontiers in Pediatrics, 2021 Objective: Immature platelet counts (IPC) may prove useful in guiding platelet transfusion management in preterm neonates. However, the relationship between IPCs and thrombopoietin (Tpo) concentrations has not been evaluated in preterm neonates.Methods ...
Hannes Sallmon +7 more
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Eltrombopag, a potent stimulator of megakaryopoiesis
Haematologica, 2016 In this issue of Haematologica , Di Buduo et al. show that eltrombopag induces human megakaryopoiesis in vitro and ex vivo through an activation of STAT, AKT and ERK pathways that is different from the other thrombomimetic, romiplostim.[1][1] Megakaryopoiesis is the process leading to ...
Hana Raslova +2 more
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Seminars in Hematology, 2010 The process of megakaryopoiesis and platelet production is complex, with the potential for regulation at multiple stages. Megakaryocytes are derived from the hematopoietic stem cell through successive lineage commitment steps, and they undergo a unique maturation process that includes polyploidization, development of an extensive internal demarcation ...
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