Results 11 to 20 of about 4,397 (174)

Eltrombopag, a potent stimulator of megakaryopoiesis

Haematologica, 2016
In this issue of Haematologica , Di Buduo et al. show that eltrombopag induces human megakaryopoiesis in vitro and ex vivo through an activation of STAT, AKT and ERK pathways that is different from the other thrombomimetic, romiplostim.[1][1] Megakaryopoiesis is the process leading to ...
Hana Raslova, William Vainchenker, Isabelle Plo   +2 more
doaj   +3 more sources

CXCR4high megakaryocytes regulate host-defense immunity against bacterial pathogens

eLife, 2022
Megakaryocytes (MKs) continuously produce platelets to support hemostasis and form a niche for hematopoietic stem cell maintenance in the bone marrow.
Jin Wang, Jiayi Xie, Daosong Wang, Xue Han, Minqi Chen, Guojun Shi, Linjia Jiang, Meng Zhao   +7 more
doaj   +1 more source

Epigenetic regulation of megakaryopoiesis and platelet formation

Haematologica
Platelets, produced by megakaryocytes, play unique roles in physiological processes, such as hemostasis, coagulation, and immune regulation, while also contributing to various clinical diseases.
Baichuan Xu, Xianpeng Ye, Zhaoyang Wen, Shilei Chen, Junping Wang   +4 more
doaj   +3 more sources

Replication of Dengue Virus in K562-Megakaryocytes Induces Suppression in the Accumulation of Reactive Oxygen Species

Frontiers in Microbiology, 2022
Dengue virus can infect human megakaryocytes leading to decreased platelet biogenesis. In this article, we report a study of Dengue replication in human K562 cells undergoing PMA-induced differentiation into megakaryocytes. PMA-induced differentiation in
Jaskaran Kaur, Yogita Rawat, Vikas Sood, Neha Periwal, Deepak Kumar Rathore, Shrikant Kumar, Niraj Kumar, Sankar Bhattacharyya   +7 more
doaj   +1 more source

M2 macrophages, but not M1 macrophages, support megakaryopoiesis by upregulating PI3K-AKT pathway activity

Signal Transduction and Targeted Therapy, 2021
Dysfunctional megakaryopoiesis hampers platelet production, which is closely associated with thrombocytopenia (PT). Macrophages (MФs) are crucial cellular components in the bone marrow (BM) microenvironment.
Hong-Yan Zhao, Yuan-Yuan Zhang, Tong Xing, Shu-Qian Tang, Qi Wen, Zhong-Shi Lyu, Meng Lv, Yu Wang, Lan-Ping Xu, Xiao-Hui Zhang, Yuan Kong, Xiao-Jun Huang   +11 more
doaj   +1 more source

Normal and malignant megakaryopoiesis [PDF]

Expert Reviews in Molecular Medicine, 2011
Megakaryopoiesis is the process by which bone marrow progenitor cells develop into mature megakaryocytes (MKs), which in turn produce platelets required for normal haemostasis. Over the past decade, molecular mechanisms that contribute to MK development and differentiation have begun to be elucidated.
Qiang, Wen, Benjamin, Goldenson, John D, Crispino   +2 more
openaire   +2 more sources

Expression of ADP receptor P2Y12, thromboxane A2 receptor and C-type lectin-like receptor 2 in cord blood-derived megakaryopoiesis

Platelets, 2021
The ADP receptor P2Y12, the thromboxane A2 receptor (TXA2R) and the C-type lectin-like receptor 2 (CLEC-2) mediate platelet activation by different mechanisms. Only little is known about the expression of the receptors in human megakaryopoiesis.
Catharina Gerhards, Stefanie Uhlig, Mani Etemad, Foteini Christodoulou, Karen Bieback, Harald Klüter, Peter Bugert   +6 more
doaj   +1 more source

Immature Platelet Counts and Thrombopoietin Plasma Concentrations in Thrombocytopenic and Non-thrombocytopenic Preterm Infants

Frontiers in Pediatrics, 2021
Objective: Immature platelet counts (IPC) may prove useful in guiding platelet transfusion management in preterm neonates. However, the relationship between IPCs and thrombopoietin (Tpo) concentrations has not been evaluated in preterm neonates.Methods ...
Hannes Sallmon, Hannes Sallmon, Hannes Sallmon, Andreas Weimann, Christoph Bührer, Boris Metze, Christof Dame, Malte Cremer   +7 more
doaj   +1 more source

Prognostic significance of mutated genes in megakaryocytic disorders

Oncology Reviews, 2019
Megakaryopoiesis is a process during which platelets that play a major role in hemostasis are produced due to differentiation and maturation of megakaryocytic precursors.
Ali Amin Asnafi, Mohammad bagher Mohammadi, Hadi Rezaeeyan, Nader Davari, Najmaldin Saki   +4 more
doaj   +1 more source

FLI1 Induces Megakaryopoiesis Gene Expression Through WAS/WIP-Dependent and Independent Mechanisms; Implications for Wiskott-Aldrich Syndrome

Frontiers in Immunology, 2021
Wiskott–Aldrich Syndrome, WAS/WAVE, is a rare, X-linked immune-deficiency disease caused by mutations in the WAS gene, which together with its homolog, N-WASP, regulates actin cytoskeleton remodeling and cell motility.
Chunlin Wang, Chunlin Wang, Klarke M. Sample, Babu Gajendran, Babu Gajendran, Philipp Kapranov, Wuling Liu, Wuling Liu, Anling Hu, Anling Hu, Eldad Zacksenhaus, Eldad Zacksenhaus, Yanmei Li, Yanmei Li, Xiaojiang Hao, Xiaojiang Hao, Yaacov Ben-David, Yaacov Ben-David   +17 more
doaj   +1 more source