Results 41 to 50 of about 7,888 (191)

A Model for Megakaryopoiesis with State-Dependent Delay [PDF]

SIAM Journal on Applied Mathematics, 2019
Summary: We analyze the stability of a system of differential equations with a threshold-defined delay arising from a model for platelet production. We consider a maturity-structured population of megakaryocyte progenitors and an age-structured population of platelets, where the cytokine thrombopoietin (TPO) increases the maturation rate of progenitors.
Boullu, Loïs, Pujo-Menjouet, Laurent, Wu, Jianhong   +2 more
openaire   +4 more sources

Megakaryopoiesis impairment through acute innate immune signaling activation by azacitidine

Journal of Experimental Medicine, 2022
Mitigation of treatment-induced thrombocytopenia is an unmet clinical need in patients with myelodysplastic syndrome or acute myeloid leukemia undergoing azacitidine therapy. Okoye-Okafor et al.
U. C. Okoye-Okafor, K. Javarappa, D. Tsallos, J. Saad, Daozheng Yang, Chi Zhang, Lumie Benard, V. Thiruthuvanathan, Sally Cole, Stephen Ruiz, Madhuri Tatiparthy, G. Choudhary, Stefanie DeFronzo, Boris A. Bartholdy, C. Pallaud, P. Ramos, A. Shastri, Amit Verma, C. Heckman, B. Will   +19 more
semanticscholar   +1 more source

FLI1 Induces Megakaryopoiesis Gene Expression Through WAS/WIP-Dependent and Independent Mechanisms; Implications for Wiskott-Aldrich Syndrome

Frontiers in Immunology, 2021
Wiskott–Aldrich Syndrome, WAS/WAVE, is a rare, X-linked immune-deficiency disease caused by mutations in the WAS gene, which together with its homolog, N-WASP, regulates actin cytoskeleton remodeling and cell motility.
Chunlin Wang, Klarke M. Sample, Babu Gajendran, P. Kapranov, Wu-Ling Liu, Anling Hu, E. Zacksenhaus, Yan-Mei Li, X. Hao, Y. Ben-David   +9 more
semanticscholar   +1 more source

Acute inflammation induces acute megakaryopoiesis with impaired platelet production during fetal hematopoiesis.

Development
Hematopoietic development is tightly regulated by various factors. The role of RNA m6A modification during fetal hematopoiesis, particularly in megakaryopoiesis, remains unclear.
Xiaojie Hu, Yirui He, Sheng-Wei Li, Yue Jiang, Renjie Yu, Yi Wu, Xiaoying Fu, Yuanbin Song, ChangDong Lin, Jiejun Shi, Hua-Bing Li, Yimeng Gao   +11 more
semanticscholar   +1 more source

Interplay between FLI-1 and the LDB1 complex in murine erythroleukemia cells and during megakaryopoiesis

iScience, 2021
Summary Transcription factors are key players in a broad range of cellular processes such as cell-fate decision. Understanding how they act to control these processes is of critical importance for therapy purposes.
G. Giraud, Petros Kolovos, Ilias Boltsis, J. van Staalduinen, B. Guyot, M. Weiss‐Gayet, W. V. van Ijcken, F. Morlé, F. Grosveld   +8 more
semanticscholar   +1 more source

Suppressive effects of anthrax lethal toxin on megakaryopoiesis. [PDF]

, 2013
Anthrax lethal toxin (LT) is a major virulence factor of Bacillus anthracis. LT challenge suppresses platelet counts and platelet function in mice, however, the mechanism responsible for thrombocytopenia remains unclear.
Chi-Yuan Liao, Guan-Ling Lin (392790), Ming-Chun Hsieh, Jyh-Hwa Kau (359055), Guan-Ling Lin, Hui-Ling Hsu (37324), Po-Kong Chen (392789), Hsin-Hou Chang (221399), Yi-Ling Lai, Ting-Kai Lin (392793), Hui-Ling Hsu, Tsung-Pao Wang (392791), Der-Shan Sun (331824), Ting-Kai Lin, Jyh-Hwa Kau, Chi-Yuan Liao (392795), Hsin-Hsien Huang (359062), Hsin-Hsien Huang, Tsung-Pao Wang, Yi-Ling Lai (392792), Der-Shan Sun, Po-Kong Chen, Hsin-Hou Chang, Ming-Chun Hsieh (392794)   +23 more
core   +1 more source

Metabolic sensor O‐GlcNAcylation regulates megakaryopoiesis and thrombopoiesis through c‐Myc stabilization and integrin perturbation

Stem Cells, 2021
Metabolic state of hematopoietic stem cells (HSCs) is an important regulator of self‐renewal and lineage‐specific differentiation. Posttranslational modification of proteins via O‐GlcNAcylation is an ideal metabolic sensor, but how it contributes to ...
S. Luanpitpong, Jirarat Poohadsuan, P. Klaihmon, Xing Kang, Kantpitchar Tangkiettrakul, S. Issaragrisil   +5 more
semanticscholar   +1 more source

Testing for Non‐Severe Heritable Platelet Function Disorders

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Heritable platelet function disorders (HPFD) are a diverse group of bleeding disorders characterised by a primary qualitative defect in platelet function rather than platelet number. HPFD may be broadly categorised according to the severity of bleeding, with Glanzmann thrombasthenia and Bernard Soulier syndrome classically considered severe ...
Kate Burley, Naomi Cornish, Maria Molina Carretero, Sarah K. Westbury   +3 more
wiley   +1 more source

The Hippo-p53 pathway in megakaryopoiesis

Haematologica, 2016
Megakaryocytes are among the largest and rarest cells in the body, accounting for approximately 0.01% of nucleated cells in the bone marrow. Their differentiation involves a progression from hematopoietic stem cell to the megakaryocyte progenitor and finally to platelets.[1][1] A key step in ...
Praveen K Suraneni, John D. Crispino
openaire   +3 more sources

Blood Cell Counts and the Duffy Null Phenotype: Beyond Neutropenia

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT The absence of Duffy antigen expression on red blood cells, caused by a single nucleotide polymorphism in the DARC/ACKR1 gene, confers protection against malaria and is associated with lower absolute neutrophil counts (ANC) in some studied populations.
Elvira Deolinda R. P. Velloso, Andreza Oliveira dos Santos, Carla Luana Dinardo, Carolina Bonet Bub, Leandro Dinalli Santos, Mauren Fernanda Moller dos Santos, João Carlos de Campos Guerra, Denise dos Anjos Laurentis de Sousa Campos, Monica Juliana Vieira, Fábio Julio da Luz, Alfredo Mendrone‐Junior, Rosana M. Cosentino Penteado   +11 more
wiley   +1 more source