Results 41 to 50 of about 4,397 (174)

A quantitative dissection of the DNA‐binding properties of pathogenic GATA1 mutants

The FEBS Journal, EarlyView.
Transcription factor activity is influenced by cell context, accessibility of target sequences, and co‐factor recruitment. Quantitatively characterizing the consequences of individual mutations in the transcription factors or their target sequences remains technically challenging. Zambo et al. use mutant GATA1‐ATP2B4 binding to illustrate an innovation
Kaoru Takasaki
wiley   +1 more source

Thrombocytopenia in dengue infection: mechanisms and a potential application

Expert Reviews in Molecular Medicine
Thrombocytopenia is a common symptom and one of the warning signs of dengue virus (DENV) infection. Platelet depletion is critical as it may lead to other severe dengue symptoms.
Ahmad Suhail Khazali, Waqiyuddin Hilmi Hadrawi, Fatimah Ibrahim, Shatrah Othman, Nurshamimi Nor Rashid   +4 more
doaj   +1 more source

Testing for Non‐Severe Heritable Platelet Function Disorders

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Heritable platelet function disorders (HPFD) are a diverse group of bleeding disorders characterised by a primary qualitative defect in platelet function rather than platelet number. HPFD may be broadly categorised according to the severity of bleeding, with Glanzmann thrombasthenia and Bernard Soulier syndrome classically considered severe ...
Kate Burley, Naomi Cornish, Maria Molina Carretero, Sarah K. Westbury   +3 more
wiley   +1 more source

Decreased Expression of IL‐35 and Its Receptor Contributes to Impaired Megakaryopoiesis in the Pathogenesis of Immune Thrombocytopenia

Advanced Science
Recent findings have shown that the level of interleukin‐35 (IL‐35) is abnormal in several autoimmune diseases. Nonetheless, whether IL‐35 participates in the pathogenesis of immune thrombocytopenia (ITP) remains unclear.
Xuan Cai, Ruo‐Yun Gui, Jin Wu, Chen‐Cong Wang, Xiao‐Lu Zhu, Hai‐Xia Fu, Xiao‐Hui Zhang   +6 more
doaj   +1 more source

Interleukins in Platelet Biology: Unraveling the Complex Regulatory Network

Pharmaceuticals
Interleukins, a diverse family of cytokines produced by various cells, play crucial roles in immune responses, immunoregulation, and a wide range of physiological and pathological processes.
Miao Huang, Long Wang, Qianhui Zhang, Ling Zhou, Rui Liao, Anguo Wu, Xinle Wang, Jiesi Luo, Feihong Huang, Wenjun Zou, Jianming Wu   +10 more
doaj   +1 more source

Suppressive effects of anthrax lethal toxin on megakaryopoiesis. [PDF]

PLoS ONE, 2013
Anthrax lethal toxin (LT) is a major virulence factor of Bacillus anthracis. LT challenge suppresses platelet counts and platelet function in mice, however, the mechanism responsible for thrombocytopenia remains unclear.
Po-Kong Chen, Hsin-Hou Chang, Guan-Ling Lin, Tsung-Pao Wang, Yi-Ling Lai, Ting-Kai Lin, Ming-Chun Hsieh, Jyh-Hwa Kau, Hsin-Hsien Huang, Hui-Ling Hsu, Chi-Yuan Liao, Der-Shan Sun   +11 more
doaj   +1 more source

The German ONKOPEDIA Guideline for Myelofibrosis in 2025—Recommendations of an MPN Expert Panel of the German Society for Hematology and Oncology (DGHO)

International Journal of Cancer, Volume 159, Issue 7, Page 1633-1641, 1 October 2026.
ABSTRACT The recently published ONKOPEDIA guideline on myelofibrosis, issued under the auspices of the German Society of Hematology and Oncology (DGHO), provides an updated, evidence‐based framework for the diagnosis and management of this rare, chronic myeloproliferative neoplasm.
Martin Griesshammer, Haifa Kathrin Al‐Ali, Gabriela M. Baerlocher, Konstanze Döhner, Steffen Koschmieder, Nicolaus Kröger, Petro E. Petrides, Dominik Wolf, Florian H. Heidel   +8 more
wiley   +1 more source

Rasa3 controls megakaryocyte Rap1 activation, integrin signaling and differentiation into proplatelet. [PDF]

PLoS Genetics, 2014
Rasa3 is a GTPase activating protein of the GAP1 family which targets Ras and Rap1. Ubiquitous Rasa3 catalytic inactivation in mouse results in early embryonic lethality.
Patricia Molina-Ortiz, Séléna Polizzi, Eve Ramery, Stéphanie Gayral, Céline Delierneux, Cécile Oury, Shintaro Iwashita, Stéphane Schurmans   +7 more
doaj   +1 more source

Association of Preoperative Inflammatory Markers With Preoperative Anxiety and Emergence Agitation in Children

Pediatric Anesthesia, Volume 36, Issue 9, Page 1132-1142, September 2026.
ABSTRACT Introduction Emergence agitation (EA) is a postoperative neurobehavioral complication characterized by a transient disturbance in cognition and perception following anesthesia. Neuroinflammation is thought to play a central role in its pathophysiology.
Nezahat Merve Ata Soylu, Zehra Hatipoglu, Ersel Gulec, Mediha Turktan, Nurefsan Sadıkoglu, Yusuf Kemal Arslan, Dilek Ozcengiz   +6 more
wiley   +1 more source

From Hematopoietic Stem Cells to Platelets: Unifying Differentiation Pathways Identified by Lineage Tracing Mouse Models

Cells
Platelets are the terminal progeny of megakaryocytes, primarily produced in the bone marrow, and play critical roles in blood homeostasis, clotting, and wound healing.
Bryce A. Manso, Alessandra Rodriguez y Baena, E. Camilla Forsberg   +2 more
doaj   +1 more source