Results 21 to 30 of about 4,397 (174)

Megakaryopoiesis [PDF]

Seminars in Hematology, 2010
The process of megakaryopoiesis and platelet production is complex, with the potential for regulation at multiple stages. Megakaryocytes are derived from the hematopoietic stem cell through successive lineage commitment steps, and they undergo a unique maturation process that includes polyploidization, development of an extensive internal demarcation ...
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Excessive serine from the bone marrow microenvironment impairs megakaryopoiesis and thrombopoiesis in Multiple Myeloma

Nature Communications, 2023
Thrombocytopenia is a major complication in a subset of patients with multiple myeloma (MM). However, little is known about its development and significance during MM. Here, we show thrombocytopenia is linked to poor prognosis in MM.
Chunmei Kuang, Meijuan Xia, Gang An, CuiCui Liu, Cong Hu, Jingyu Zhang, Zhenhao Liu, Bin Meng, Pei Su, Jiliang Xia, Jiaojiao Guo, Yinghong Zhu, Xing Liu, Xuan Wu, Yi Shen, Xiangling Feng, Yanjuan He, Jian Li, Lugui Qiu, Jiaxi Zhou, Wen Zhou   +20 more
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Hybrid Models in Erythropoiesis and in Megakaryopoiesis [PDF]

Mathematical Modelling of Natural Phenomena, 2015
Summary: Hematopoiesis is a complex process which results in production of erythrocytes, platelets and white blood cells from pluripotent stem cells located in the bone marrow. We will present hybrid models of hematopoiesis and will use them to study the lineage choice of bipotent erythro-megakaryocytic progenitors and erythroid lineage of ...
Eymard, N., Kurbatova, P.
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Caulis Polygoni Multiflori Accelerates Megakaryopoiesis and Thrombopoiesis via Activating PI3K/Akt and MEK/ERK Signaling Pathways

Pharmaceuticals, 2022
Thrombocytopenia is one of the most common complications of cancer therapy. Until now, there are still no satisfactory medications to treat chemotherapy and radiation-induced thrombocytopenia (CIT and RIT, respectively). Caulis Polygoni Multiflori (CPM),
Xin Yang, Long Wang, Jing Zeng, Anguo Wu, Mi Qin, Min Wen, Ting Zhang, Wang Chen, Qibing Mei, Dalian Qin, Jing Yang, Yu Jiang, Jianming Wu   +12 more
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Novel function of FAXDC2 in megakaryopoiesis [PDF]

Blood Cancer Journal, 2016
AbstractFAXDC2 (fatty acid hydroxylase domain containing 2) is a member of the fatty acid hydroxylase superfamily. Given the important role of fatty acids in megakaryocytes, we have studied the role of this gene in the development of this lineage. Here we show that the expression of FAXDC2 is constantly elevated during megakaryocyte maturation.
Jin, Q, Ren, Y, Wang, M, Suraneni, P K, Li, D, Crispino, J D, Fan, J, Huang, Z   +7 more
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BMP2K dysregulation promotes abnormal megakaryopoiesis in acute megakaryoblastic leukemia

Cell & Bioscience, 2020
Background Forced polyploidization is an effective strategy for acute megakaryoblastic leukemia (AMKL) therapy and factors controlling polyploidization are potential targets for drug development. Although bone morphology protein 2-inducible kinase (BMP2K)
Manman Wang, Tan Zhang, Xuechun Zhang, Zhou Jiang, Min Peng, Zan Huang   +5 more
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PKCθ is dispensable for megakaryopoiesis

Platelets, 2014
Megakaryocytes are large polyploid cells that produce platelets. Megakaryocytes undergo an abbreviated cell cycle (known as endomitosis) that does not proceed to cytokinesis [1].
John C, Kostyak, Satya P, Kunapuli
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The Involvement of Canonical NFκB Pathway in Megakaryocyte Differentiation Induction by Nanocurcumin

International Journal of Hematology-Oncology and Stem Cell Research, 2023
Background: Megakaryopoiesis is characterized by progressive polyploidization and the expression of megakaryocytic markers. Numerous transcription factors and physiological signaling pathways regulate this phenomenon.
Seyedeh Sahar Mortazavi Farsani, Dina Sadeghizadeh, Sadegh Babashah, Fariba Rad, Majid Sadeghizadeh   +4 more
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Developmental changes in human megakaryopoiesis [PDF]

Journal of Thrombosis and Haemostasis, 2013
The molecular bases of the cellular changes that occur during human megakaryocyte (MK) ontogeny remain unknown, and may be important for understanding the significance of MK differentiation from human embryonic stem cells (hESCs)We optimized the differentiation of MKs from hESCs, and compared these with MKs obtained from primary human hematopoietic ...
O, Bluteau, T, Langlois, P, Rivera-Munoz, F, Favale, P, Rameau, G, Meurice, P, Dessen, E, Solary, H, Raslova, T, Mercher, N, Debili, W, Vainchenker   +11 more
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miR-142 orchestrates a network of actin cytoskeleton regulators during megakaryopoiesis

eLife, 2014
Genome-encoded microRNAs (miRNAs) provide a posttranscriptional regulatory layer that controls the differentiation and function of various cellular systems, including hematopoietic cells. miR-142 is one of the most prevalently expressed miRNAs within the
Elik Chapnik, Natalia Rivkin, Alexander Mildner, Gilad Beck, Ronit Pasvolsky, Eyal Metzl-Raz, Yehudit Birger, Gail Amir, Itay Tirosh, Ziv Porat, Liron L Israel, Emmanuel Lellouche, Shulamit Michaeli, Jean-Paul M Lellouche, Shai Izraeli, Steffen Jung, Eran Hornstein   +16 more
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