Results 21 to 30 of about 7,888 (191)

Dysplastic megakaryopoiesis with thrombocytopenia and chromosomal aberration

American Journal of Clinical Pathology, 1992
A case of isolated thrombocytopenia with decreased platelet production and abnormal megakaryopoiesis is described. In the bone marrow, a chromosomally aberrant clone, 45,XX,-11,-18,+der (11;18)(11q13;18p11), was found.
Swolin, Birgitta,, Ridell, Börje,, Kutti, Jack,, Wadenvik, Hans,   +3 more
core   +3 more sources

Overexpression of heparanase in mice promoted megakaryopoiesis [PDF]

Glycobiology, 2018
Heparanase, an endo-glucuronidase that specifically cleaves heparan sulfate (HS), is upregulated in several pathological conditions. In this study, we aimed to find a correlation of heparanase expression and platelets production.
Gong, Feng,, Zhang, Xiao,, Lu-Ming Wan, Feng Gong, Israel Vlodavsky, Wan, Lu-Ming,, Li, Jin-Ping,, Jin-Ping Li, Cui, Hao,, Tan, Ying-Xia,, Xiao Zhang, Vlodavsky, Israel,, Ying-Xia Tan, Hao Cui   +13 more
core   +4 more sources

Novel regulators of megakaryopoiesis: The road less traveled by [PDF]

, 2015
Platelet transfusions are given to patients with low platelet counts due to, for example, chemotherapy. Currently, research is done to produce platelets in culture systems.
Zeddies, S.
core   +13 more sources

New gene functions in megakaryopoiesis and platelet formation [PDF]

, 2011
Platelets are the second most abundant cell type in blood and are essential for maintaining haemostasis. Their count and volume are tightly controlled within narrow physiological ranges, but there is only limited understanding of the molecular processes ...
Pistis, Giorgio, Hazen, Stanley L., Hottenga, Bradley, John R., Jerome I., Psaty, Bruce M., Toniolo, Daniela, Bomba, Ferreira, Manuel A., Porcu, Eleonora, McKnight, Barbara, Memari, Yasin, Goegele, Martin, Mitchell, Braxton D., Sanna, Serena, Pirastu, Mario, Labrune, Yann, Nakamura, Yusuke, Erdmann, Jeanette, Jovana, Maschio, Andrea, Nolte, Ilja M., Soranzo, Basu, Saonli, Hengstenberg, Christian, Loos, Ruth J. F., Tang, Tenesa, Albert, Elliott, Paul, Kyrtsonis, Marie-Christine, Penninger, Josef, Smith, Franke, Andre, Ellinghaus, David, Gasparini, Paolo, Weihong, Toenjes, Anke, de Boer, Gonneke, Goodall, Alison H., Kovacs, Peter, Akkerman, Jan-Willem N., Kanoni, Hicks, Andrew A., Wei, Bonnefond, Amelie, Martin, Nicholas G., Parsa, Afshin, van der Harst, Pim, Yukinori, Frazer, Ian H., Ruggiero, Daniela, Samani, Nilesh J., Greinacher, Andreas, Boomsma, Rotter, C., Rudolf A., Folsom, Aaron R., Shuldiner, Davies, Gail, Langenberg, Claudia, Nicole, Augusto, Esko, Toenu, Chambers, John, Elling, Ulrich, Wiggins, Kerri L., Rendon, Mangino, Hersch, Micha, van Veldhuisen, Dirk J., Gieger, Christian, Sorice, Rossella, Pullat, Janne, Ruokonen, Aimo, Kuehnel, Brigitte, Vasiliki, Massimo, Dorret I., Jouke-Jan, D'Adamo, Pio, Shin, So-Youn, Cambien, Francois, Ganesh, Santhi K., van der Schoot, C. Ellen, Voelker, Uwe, Gibson, Quince D., Khadake, Jyoti, Heckbert, Susan R., Meisinger, Christa, Khaw, Kay, Kooner, Jaspal S., Lorenzo, Hartikainen, Anna-Liisa, Ulivi, Sheila, Jupe, Steve, Naoyuki, Ramirez-Solis, Ramiro, Jarvelin, Marjo-Riitta, Wichmann, H-Erich, Bastardot, Francois, Serbanovic-Canic, Pouta, Anneli, Lopez, Lorna M., Lagou, Biino, Ginevra, Ute, Starr, John M., Voss, Katrin, Montgomery, Grant W., Leach, Irene Mateo, Schreiber, Stefan, Takahashi, Atsushi, Doering, Angela, Taylor, Kent, Zwaginga, Jaap-Jan, O'Reilly, Paul, Balkau, Beverley, Tang, W. H. Wilson, Maegi, Reedik, Cvejic, Ana, Deloukas, Panos, F., Okada, Murgia, Federico, Schunkert, Heribert, Thein, Swee Lay, Wareham, Nicholas J., Stemple, Derek, Snieder, Harold, Navis, Gerjan, Zhang, Weihua, Zhao, Jing Hua, Kamatani, Sala, Cinzia, Sambrook, Jennifer, Dedoussis, George V., Nicholas L., Falchi, Mario, Ciullo, Marina, Nauck, Matthias, Stumvoll, Michael, Lumley, Thomas, Froguel, Philippe, Cucca, Francesco, Deary, Ian J., de Geus, Eco J. C., Ring, Susan M., Joshua C., Scott, James, Schlessinger, David, Alan R., Glazer, Nicole L., Illig, Thomas, Willemsen, Meacham, Stuart, Jolley, Jennifer, Evans, David M., Hartiala, Jaana, Zitting, Paavo, Pirastu, Nicola, Stavroula, Stephens, Jonathan, Yang, Tsun-Po, Lloyd-Jones, Heather, Uda, Manuela, Spector, Timothy D., Prokopenko, Inga, Visscher, Peter M., Allayee, Hooman, Porteous, David J., van Pelt, L. Joost, Bis, Teumer, Alexander, Wernisch, Lorenz, Radhakrishnan, Aparna, Noethlings, Pramstaller, Peter P., Tee, Feng, Attwood, Antony, Hammond, Chris, Ouwehand, Willem H., Baumeister, Sebastian E., Metspalu, Andres   +185 more
core   +5 more sources

Efficient megakaryopoiesis and platelet production require phospholipid remodeling and PUFA uptake through CD36

bioRxiv, 2023
Lipids contribute to hematopoiesis and membrane properties and dynamics, however, little is known about the role of lipids in megakaryopoiesis. Here, a lipidomic analysis of megakaryocyte progenitors, megakaryocytes, and platelets revealed a unique ...
María N. Barrachina, G. Pernes, Isabelle C. Becker, I. Allaeys, Thomas I. Hirsch, D. Groeneveld, A. O. Khan, Daniela Freire, K. Guo, Estelle Carminita, Pooranee K. Morgan, Thomas J. C. Collins, N. Mellett, Zi-Mu Wei, I. Almazni, J. Italiano, J. Luyendyk, P. Meikle, M. Puder, N. Morgan, É. Boilard, A. Murphy, K. Machlus   +22 more
semanticscholar   +1 more source

Single-Cell Analysis of Ploidy and Transcriptome Reveals Functional and Spatial Divergency in Murine Megakaryopoiesis.

Blood, 2021
Megakaryocytes (MKs), the platelet progenitor cell, play important roles in hematopoietic stem cell (HSC) maintenance and immunity. However, it is not known whether these diverse programs are executed by a single population or by distinct subsets of ...
Shu Sun, Chen Jin, Jia Si, Ying Lei, Kun-Ying Chen, Yueli Cui, Zhen-Bo Liu, Jiang Liu, Meng Zhao, Xiao-Hui Zhang, Fu-Chou Tang, M. Rondina, Yueying Li, Qian-Fei Wang   +13 more
semanticscholar   +1 more source

Megakaryopoiesis [PDF]

Seminars in Hematology, 2010
The process of megakaryopoiesis and platelet production is complex, with the potential for regulation at multiple stages. Megakaryocytes are derived from the hematopoietic stem cell through successive lineage commitment steps, and they undergo a unique maturation process that includes polyploidization, development of an extensive internal demarcation ...
openaire   +2 more sources

ABCC4 Impacts Megakaryopoiesis and Protects Megakaryocytes against 6-Mercaptopurine Induced Cytotoxicity

Drug resistance updates, 2023
The role of ABCC4, an ATP-binding cassette transporter, in the process of platelet formation, megakaryopoiesis, is unknown. Here, we show that ABCC4 is highly expressed in megakaryocytes (MKs).
Sabina Ranjit, Yao Wang, Jingwen Zhu, S. Cheepala, Erin G. Schuetz, Jung-Cho Woo, Bei-Si Xu, Cam Robinson, Gang Wu, A. Naren, J. Schuetz   +10 more
semanticscholar   +1 more source

Synergistic roles of DYRK1A and GATA1 in trisomy 21 megakaryopoiesis

JCI Insight, 2023
Patients with Down syndrome (DS), or trisomy 21 (T21), are at increased risk of transient abnormal myelopoiesis (TAM) and acute megakaryoblastic leukemia (ML-DS).
Ying-Ting Sit, K. Takasaki, H. An, Yan Xiao, C. Hurtz, Peter A Gearhart, Zhe Zhang, Paul J. Gadue, Deborah L. French, Stella T. Chou   +9 more
semanticscholar   +1 more source

Thrombopoietin-Dependent Myelo-Megakaryopoiesis Fuels Thromboinflammation and Worsens Antibody-Mediated Chronic Renal Microvascular Injury

Journal of the American Society of Nephrology, 2023
Significance Statement Kidney-derived thrombopoietin (TPO) increases myeloid cell and platelet production during antibody-mediated chronic kidney disease (AMCKD) in a mouse model, exacerbating chronic thromobinflammation in microvessels.
M. Douté, A. Sannier, G. Even, T. Tran, A. Gaston, S. Delbosc, S. Loyau, P. Bruneval, V. Witko-Sarsat, L. Mouthon, A. Nicoletti, G. Caligiuri, M. Clément   +12 more
semanticscholar   +1 more source