Results 31 to 40 of about 4,363 (174)

Developmental changes in human megakaryopoiesis [PDF]

Journal of Thrombosis and Haemostasis, 2013
The molecular bases of the cellular changes that occur during human megakaryocyte (MK) ontogeny remain unknown, and may be important for understanding the significance of MK differentiation from human embryonic stem cells (hESCs)We optimized the differentiation of MKs from hESCs, and compared these with MKs obtained from primary human hematopoietic ...
O, Bluteau, T, Langlois, P, Rivera-Munoz, F, Favale, P, Rameau, G, Meurice, P, Dessen, E, Solary, H, Raslova, T, Mercher, N, Debili, W, Vainchenker   +11 more
openaire   +2 more sources

miR-142 orchestrates a network of actin cytoskeleton regulators during megakaryopoiesis

eLife, 2014
Genome-encoded microRNAs (miRNAs) provide a posttranscriptional regulatory layer that controls the differentiation and function of various cellular systems, including hematopoietic cells. miR-142 is one of the most prevalently expressed miRNAs within the
Elik Chapnik, Natalia Rivkin, Alexander Mildner, Gilad Beck, Ronit Pasvolsky, Eyal Metzl-Raz, Yehudit Birger, Gail Amir, Itay Tirosh, Ziv Porat, Liron L Israel, Emmanuel Lellouche, Shulamit Michaeli, Jean-Paul M Lellouche, Shai Izraeli, Steffen Jung, Eran Hornstein   +16 more
doaj   +1 more source

Mercury Chloride Impacts on the Development of Erythrocytes and Megakaryocytes in Mice

Toxics, 2021
Inorganic mercury (Hg2+) is a highly toxic heavy metal. The aim of this study was to investigate the impact of Hg2+ on the development of erythrocytes and megakaryocytes.
Jinyi He, Yifan Zhao, Tingting Zhu, Peng Xue, Weiwei Zheng, Ye Yao, Weidong Qu, Xiaodong Jia, Rongzhu Lu, Miao He, Yubin Zhang   +10 more
doaj   +1 more source

Annexin V and CXCR4 Expression in Adult Immune Thrombocytopenia. Control Randomized Study [PDF]

Journal of Bioscience and Applied Research, 2018
Background: Annexin V is a cellular protein used to detect apoptotic cells by its ability to bind to phosphatidylserine, a marker of apoptosis when it is on the outer leaflet of the plasma membrane.CXCR4 is expressed on cells of megakaryocytic series ...
Rania fawzy, Amal Nasr, Noha El Husseiny, Mona Gamil, Heba El Demellawy, Hend Hassan, Ibrahim Ibrahim   +6 more
doaj   +1 more source

PI3K/HSCB axis facilitates FOG1 nuclear translocation to promote erythropoiesis and megakaryopoiesis

eLife
Erythropoiesis and megakaryopoiesis are stringently regulated by signaling pathways. However, the precise molecular mechanisms through which signaling pathways regulate key transcription factors controlling erythropoiesis and megakaryopoiesis remain ...
Gang Liu, Yunxuan Hou, Xin Jin, Yixue Zhang, Chaoyue Sun, Chengquan Huang, Yujie Ren, Jianmin Gao, Xiuli Wang, Xiumei Jiang   +9 more
doaj   +1 more source

A Model for Megakaryopoiesis with State-Dependent Delay [PDF]

SIAM Journal on Applied Mathematics, 2019
Summary: We analyze the stability of a system of differential equations with a threshold-defined delay arising from a model for platelet production. We consider a maturity-structured population of megakaryocyte progenitors and an age-structured population of platelets, where the cytokine thrombopoietin (TPO) increases the maturation rate of progenitors.
Boullu, Loïs, Pujo-Menjouet, Laurent, Wu, Jianhong   +2 more
openaire   +4 more sources

Interplay between FLI-1 and the LDB1 complex in murine erythroleukemia cells and during megakaryopoiesis

iScience, 2021
Summary: Transcription factors are key players in a broad range of cellular processes such as cell-fate decision. Understanding how they act to control these processes is of critical importance for therapy purposes.
Guillaume Giraud, Petros Kolovos, Ilias Boltsis, Jente van Staalduinen, Boris Guyot, Michele Weiss-Gayet, Wilfred van IJcken, François Morlé, Frank Grosveld   +8 more
doaj   +1 more source

Inside-to-outside and back to the future of megakaryopoiesis

Research and Practice in Thrombosis and Haemostasis, 2023
A State of the Art lecture titled "Megakaryocytes and different thrombopoietic environments" was presented at the ISTH Congress in 2022. Circulating platelets are specialized cells produced by megakaryocytes. Leading studies point to the bone marrow niche as the core of hematopoietic stem cell differentiation, revealing interesting and complex ...
Di Buduo, Christian Andrea, Miguel, Carolina Paula, Balduini, Alessandra   +2 more
openaire   +3 more sources

The German ONKOPEDIA Guideline for Myelofibrosis in 2025—Recommendations of an MPN Expert Panel of the German Society for Hematology and Oncology (DGHO)

International Journal of Cancer, EarlyView.
ABSTRACT The recently published ONKOPEDIA guideline on myelofibrosis, issued under the auspices of the German Society of Hematology and Oncology (DGHO), provides an updated, evidence‐based framework for the diagnosis and management of this rare, chronic myeloproliferative neoplasm.
Martin Griesshammer, Haifa Kathrin Al‐Ali, Gabriela M. Baerlocher, Konstanze Döhner, Steffen Koschmieder, Nicolaus Kröger, Petro E. Petrides, Dominik Wolf, Florian H. Heidel   +8 more
wiley   +1 more source

Calreticulin in Essential Thrombocythemia: StressINg OUT the Megakaryocyte Nucleus

Frontiers in Oncology, 2017
Calreticulin (CALR) is a multifaceted protein primarily involved in intracellular protein control processes. The identification of CALR mutations in essential thrombocythemia (ET) and primary myelofibrosis that are mutually exclusive with the JAK2 V617F ...
Francisco Jose Iborra, Petros Papadopoulos   +1 more
doaj   +1 more source