Results 31 to 40 of about 7,888 (191)

Hybrid Models in Erythropoiesis and in Megakaryopoiesis [PDF]

Mathematical Modelling of Natural Phenomena, 2015
Summary: Hematopoiesis is a complex process which results in production of erythrocytes, platelets and white blood cells from pluripotent stem cells located in the bone marrow. We will present hybrid models of hematopoiesis and will use them to study the lineage choice of bipotent erythro-megakaryocytic progenitors and erythroid lineage of ...
Eymard, N., Kurbatova, P.
openaire   +2 more sources

PKCθ is dispensable for megakaryopoiesis

Platelets, 2014
Megakaryocytes are large polyploid cells that produce platelets. Megakaryocytes undergo an abbreviated cell cycle (known as endomitosis) that does not proceed to cytokinesis [1].
John C, Kostyak, Satya P, Kunapuli
openaire   +2 more sources

A Novel Antithrombocytopenia Agent, Rhizoma cibotii, Promotes Megakaryopoiesis and Thrombopoiesis through the PI3K/AKT, MEK/ERK, and JAK2/STAT3 Signaling Pathways

International Journal of Molecular Sciences, 2022
Background: Cibotii rhizoma (CR) is a famous traditional Chinese medicine (TCM) used to treat bleeding, rheumatism, lumbago, etc. However, its therapeutic effects and mechanism against thrombocytopenia are still unknown so far.
Wang-Chi Chen, Lin-wen-si Zhu, Long Wang, Jing-zhang Zeng, Min Wen, Xiyan Xu, Li-Le Zou, Feihong Huang, Qian-Qian Huang, Da-Lian Qin, Qibing Mei, Jing Yang, Qiaozhi Wang, Jian-Ming Wu   +13 more
semanticscholar   +1 more source

Novel function of FAXDC2 in megakaryopoiesis [PDF]

Blood Cancer Journal, 2016
AbstractFAXDC2 (fatty acid hydroxylase domain containing 2) is a member of the fatty acid hydroxylase superfamily. Given the important role of fatty acids in megakaryocytes, we have studied the role of this gene in the development of this lineage. Here we show that the expression of FAXDC2 is constantly elevated during megakaryocyte maturation.
Jin, Q, Ren, Y, Wang, M, Suraneni, P K, Li, D, Crispino, J D, Fan, J, Huang, Z   +7 more
openaire   +2 more sources

Megakaryopoiesis and Platelet Biology: Roles of Transcription Factors and Emerging Clinical Implications

International Journal of Molecular Sciences, 2021
Platelets play a critical role in hemostasis and thrombus formation. Platelets are small, anucleate, and short-lived blood cells that are produced by the large, polyploid, and hematopoietic stem cell (HSC)-derived megakaryocytes in bone marrow ...
J. Noh
semanticscholar   +1 more source

Bifunctional effect of the inflammatory cytokine tumor necrosis factor α on megakaryopoiesis and platelet production

Journal of Thrombosis and Haemostasis, 2022
Platelets are affected by many factors, such as infectious or aseptic inflammation, and different inflammatory states may induce either thrombocytopenia or thrombocytosis. Tumor necrosis factor α (TNFα) is an important inflammatory cytokine that has been
Tiantian Chu, Shu-Lin Hu, Jia-Qian Qi, Xueqian Li, Xiang Zhang, Ya-Qiong Tang, Menglu Yang, Yang Xu, C. Ruan, Y. Han, De-Pei Wu   +10 more
semanticscholar   +1 more source

Developmental changes in human megakaryopoiesis [PDF]

Journal of Thrombosis and Haemostasis, 2013
The molecular bases of the cellular changes that occur during human megakaryocyte (MK) ontogeny remain unknown, and may be important for understanding the significance of MK differentiation from human embryonic stem cells (hESCs)We optimized the differentiation of MKs from hESCs, and compared these with MKs obtained from primary human hematopoietic ...
O, Bluteau, T, Langlois, P, Rivera-Munoz, F, Favale, P, Rameau, G, Meurice, P, Dessen, E, Solary, H, Raslova, T, Mercher, N, Debili, W, Vainchenker   +11 more
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Microbiota-Derived Propionate Modulates Megakaryopoiesis and Platelet Function

Frontiers in Immunology, 2022
Rheumatoid arthritis (RA) is associated with an increased risk for cardiovascular events driven by abnormal platelet clotting effects. Platelets are produced by megakaryocytes, deriving from megakaryocyte erythrocyte progenitors (MEP) in the bone marrow.
K. Dürholz, E. Schmid, M. Frech, V. Azizov, Nadine Otterbein, S. Lucas, M. Rauh, G. Schett, H. Bruns, M. Zaiss   +9 more
semanticscholar   +1 more source

Caulis Polygoni Multiflori Accelerates Megakaryopoiesis and Thrombopoiesis via Activating PI3K/Akt and MEK/ERK Signaling Pathways

Pharmaceuticals, 2022
Thrombocytopenia is one of the most common complications of cancer therapy. Until now, there are still no satisfactory medications to treat chemotherapy and radiation-induced thrombocytopenia (CIT and RIT, respectively). Caulis Polygoni Multiflori (CPM),
Xin Yang, Long Wang, Jing-zhang Zeng, Anguo Wu, Ming Qin, Min Wen, Ting Zhang, Wang Chen, Qibing Mei, Da-Lian Qin, Jing Yang, Yu-lan Jiang, Jian-Ming Wu   +12 more
semanticscholar   +1 more source

Megakaryocyte/platelet-derived TGF-β1 inhibits megakaryopoiesis in bone marrow by regulating thrombopoietin production in liver

Blood Advances, 2022
Key Points Loss of Tgfb1 expression in MKs increases MK production in BM and TPO expression in the liver. Inhibition of TGF-β1 might increase MK generation in vivo and in vitro.
Sandra Gostynska, T. Venkatesan, Kumar Subramani, Brienne Cortez, A. Robertson, Sandeep M. Subrahmanian, P. Dube, Jasimuddin Ahamed   +7 more
semanticscholar   +1 more source