Results 31 to 40 of about 4,397 (174)

A novel method for automated assessment of megakaryocyte differentiation and proplatelet formation

Platelets, 2018
Transfusion of platelet concentrates represents an important treatment for various bleeding complications. However, the short half-life and frequent contaminations with bacteria restrict the availability of platelet concentrates and raise a clear demand ...
M. Salzmann, B. Hoesel, M. Haase, M. Mussbacher, WC. Schrottmaier, JB. Kral-Pointner, M. Finsterbusch, A. Mazharian, A. Assinger, JA. Schmid   +9 more
doaj   +1 more source

Annexin V and CXCR4 Expression in Adult Immune Thrombocytopenia. Control Randomized Study [PDF]

Journal of Bioscience and Applied Research, 2018
Background: Annexin V is a cellular protein used to detect apoptotic cells by its ability to bind to phosphatidylserine, a marker of apoptosis when it is on the outer leaflet of the plasma membrane.CXCR4 is expressed on cells of megakaryocytic series ...
Rania fawzy, Amal Nasr, Noha El Husseiny, Mona Gamil, Heba El Demellawy, Hend Hassan, Ibrahim Ibrahim   +6 more
doaj   +1 more source

Mercury Chloride Impacts on the Development of Erythrocytes and Megakaryocytes in Mice

Toxics, 2021
Inorganic mercury (Hg2+) is a highly toxic heavy metal. The aim of this study was to investigate the impact of Hg2+ on the development of erythrocytes and megakaryocytes.
Jinyi He, Yifan Zhao, Tingting Zhu, Peng Xue, Weiwei Zheng, Ye Yao, Weidong Qu, Xiaodong Jia, Rongzhu Lu, Miao He, Yubin Zhang   +10 more
doaj   +1 more source

PI3K/HSCB axis facilitates FOG1 nuclear translocation to promote erythropoiesis and megakaryopoiesis

eLife
Erythropoiesis and megakaryopoiesis are stringently regulated by signaling pathways. However, the precise molecular mechanisms through which signaling pathways regulate key transcription factors controlling erythropoiesis and megakaryopoiesis remain ...
Gang Liu, Yunxuan Hou, Xin Jin, Yixue Zhang, Chaoyue Sun, Chengquan Huang, Yujie Ren, Jianmin Gao, Xiuli Wang, Xiumei Jiang   +9 more
doaj   +1 more source

A Model for Megakaryopoiesis with State-Dependent Delay [PDF]

SIAM Journal on Applied Mathematics, 2019
Summary: We analyze the stability of a system of differential equations with a threshold-defined delay arising from a model for platelet production. We consider a maturity-structured population of megakaryocyte progenitors and an age-structured population of platelets, where the cytokine thrombopoietin (TPO) increases the maturation rate of progenitors.
Boullu, Loïs, Pujo-Menjouet, Laurent, Wu, Jianhong   +2 more
openaire   +4 more sources

Calreticulin in Essential Thrombocythemia: StressINg OUT the Megakaryocyte Nucleus

Frontiers in Oncology, 2017
Calreticulin (CALR) is a multifaceted protein primarily involved in intracellular protein control processes. The identification of CALR mutations in essential thrombocythemia (ET) and primary myelofibrosis that are mutually exclusive with the JAK2 V617F ...
Francisco Jose Iborra, Petros Papadopoulos   +1 more
doaj   +1 more source

Interplay between FLI-1 and the LDB1 complex in murine erythroleukemia cells and during megakaryopoiesis

iScience, 2021
Summary: Transcription factors are key players in a broad range of cellular processes such as cell-fate decision. Understanding how they act to control these processes is of critical importance for therapy purposes.
Guillaume Giraud, Petros Kolovos, Ilias Boltsis, Jente van Staalduinen, Boris Guyot, Michele Weiss-Gayet, Wilfred van IJcken, François Morlé, Frank Grosveld   +8 more
doaj   +1 more source

Inside-to-outside and back to the future of megakaryopoiesis

Research and Practice in Thrombosis and Haemostasis, 2023
A State of the Art lecture titled "Megakaryocytes and different thrombopoietic environments" was presented at the ISTH Congress in 2022. Circulating platelets are specialized cells produced by megakaryocytes. Leading studies point to the bone marrow niche as the core of hematopoietic stem cell differentiation, revealing interesting and complex ...
Di Buduo, Christian Andrea, Miguel, Carolina Paula, Balduini, Alessandra   +2 more
openaire   +3 more sources

Mechanisms of Thrombocytosis in Iron‐Deficiency Anemia

European Journal of Haematology, EarlyView.
ABSTRACT Iron‐deficiency anemia is frequently accompanied by reactive thrombocytosis, yet the mechanisms underlying this association remain incompletely understood. Beyond impaired erythropoiesis, iron availability has emerged as an active regulator of hematopoietic lineage decisions.
João Vitor Facco, Diane S. Krause, Sara T. Olalla Saad   +2 more
wiley   +1 more source

Decreased cyclooxygenase-2 associated with impaired megakaryopoiesis and thrombopoiesis in primary immune thrombocytopenia

Journal of Translational Medicine, 2023
Background Cyclooxygenase (COX)-2 is a rate-limiting enzyme in the biosynthesis of prostanoids, which is mostly inducible by inflammatory cytokines. The participation of COX-2 in the maturation of megakaryocytes has been reported but barely studied in ...
Xibing Zhuang, Pengcheng Xu, Yang Ou, Xia Shao, Ying Li, Yanna Ma, Shanshan Qin, Fanli Hua, Yanxia Zhan, Lili Ji, Tiankui Qiao, Hao Chen, Yunfeng Cheng   +12 more
doaj   +1 more source