Results 51 to 60 of about 4,397 (174)

Microbiota-Derived Propionate Modulates Megakaryopoiesis and Platelet Function

Frontiers in Immunology, 2022
Rheumatoid arthritis (RA) is associated with an increased risk for cardiovascular events driven by abnormal platelet clotting effects. Platelets are produced by megakaryocytes, deriving from megakaryocyte erythrocyte progenitors (MEP) in the bone marrow.
Kerstin Dürholz, Kerstin Dürholz, Eva Schmid, Eva Schmid, Michael Frech, Michael Frech, Vugar Azizov, Vugar Azizov, Nadine Otterbein, Nadine Otterbein, Sébastien Lucas, Sébastien Lucas, Manfred Rauh, Georg Schett, Georg Schett, Heiko Bruns, Mario M. Zaiss, Mario M. Zaiss   +17 more
doaj   +1 more source

Historical review: megakaryopoiesis and thrombopoiesis [PDF]

Blood, 2008
Abstract The study of thrombopoiesis has evolved greatly since an era when platelets were termed “the dust of the blood,” only about 100 years ago. During this time megakaryocytes were identified as the origin of blood platelets; marrow-derived megakaryocytic progenitor cells were functionally defined and then purified; and the primary ...
openaire   +2 more sources

Interstitial 11q Deletions and Terminal 11q Duplications Cause a Bleeding Tendency due to Platelet Dysfunction That Is Similar to 11q Deletions Causing Jacobsen Syndrome

European Journal of Haematology, Volume 117, Issue 3, Page 662-672, September 2026.
ABSTRACT Introduction Jacobsen syndrome, resulting from a terminal deletion of chromosome 11 (11q), may lead to an increased bleeding tendency due to low platelet counts or platelet dysfunction. Currently, information on bleeding tendency and platelet function in patients with nonterminal 11q‐aberrations such as larger deletions, interstitial 11q ...
Elise J. Huisman, Virgil A. S. H. Dalm, Marieke Joosten, Frans J. Smiers, Leendert Porcelijn, Arjan Hoogendijk, Hans Janssen, Nicole N. van der Wel, Idske C. L. Kremer Hovinga, Masja de Haas, Marjon H. Cnossen   +10 more
wiley   +1 more source

Pairing megakaryopoiesis methylation with PEAR1 [PDF]

Blood, 2016
In this issue of Blood, Izzi et al pair a platelet function–associated single-nucleotide polymorphism (SNP) with allele-specific methylation at a cytosine guanine dinucleotide (CpG) island and regulation of platelet endothelial aggregation receptor 1 (PEAR1) RNA expression in megakaryopoiesis, describing one of the first epigenetic-SNP links to ...
openaire   +2 more sources

Acute Myeloid Leukemia in a Patient With Xeroderma Pigmentosum: A Case Report

Clinical Case Reports, Volume 14, Issue 8, August 2026.
ABSTRACT Acute myeloid leukemia may occur in patients with xeroderma pigmentosum at a younger age and can be associated with complex cytogenetics and poor treatment response, highlighting the importance of regular hematologic monitoring.
Mina Soryal, Mohamed Mahmoud Marey, Malak A. Hassan, Rawan El‐Sayed, Enas Kamal Abdalaziz Seyed, Ashraf Elghandour   +5 more
wiley   +1 more source

Megakaryocytic dysfunction in immune thrombocytopenia is linked to autophagy

Cancer Cell International, 2019
Immune thrombocytopenic purpura (ITP) is a multifactorial autoimmune disease characterized by both increased platelet destruction and/or reduced platelet production.
Rui-jie Sun, Ning-ning Shan
doaj   +1 more source

Diagnostic Challenge of Pediatric Gaucher Disease in a Low‐Resource South Asian Setting: A Case Report

Clinical Case Reports, Volume 14, Issue 8, August 2026.
ABSTRACT Gaucher disease is a rare autosomal recessive lysosomal storage disorder that is caused by a deficiency of the enzyme “β‐glucocerebrosidase”, leading to the accumulation of glucocerebroside within macrophages. It commonly presents with hepatosplenomegaly, cytopenias, and bone marrow infiltration.
Muhammad Waqas, Rahila Bano, Muhammad Usman Haider, Kumar Abhishek, Arshad Mehmood, Aqeel Abbas, Abbas Ali, Talha Basheer, Rafiya Muhammad Altaf, Yahya Samadi   +9 more
wiley   +1 more source

2-O, 3-O desulfated heparin mitigates murine chemotherapy- and radiation-induced thrombocytopenia

Blood Advances, 2018
: Thrombocytopenia is a significant complication of chemotherapy and radiation therapy. Platelet factor 4 (PF4; CXCL4) is a negative paracrine of megakaryopoiesis.
Elizabeth Tkaczynski, Abinaya Arulselvan, John Tkaczynski, Stephen Avery, Liqing Xiao, Beverly Torok-Storb, Kraig Abrams, Narayanam V. Rao, Gregory Johnson, Thomas P. Kennedy, Mortimer Poncz, Michele P. Lambert   +11 more
doaj   +1 more source

Platelet-derived microparticles enhance megakaryocyte differentiation and platelet generation via miR-1915-3p

Nature Communications, 2020
Platelets derive from megakaryocytes, which differentiate from hematopoietic stem/progenitor cells (HSPCs). Here, Qu et al show that platelet-derived microparticles carrying miR-1915-3p target HSPCs and promote megakaryopoiesis by suppressing RHOB ...
Mingyi Qu, Xiaojing Zou, Fang Fang, Shouye Wang, Lei Xu, Quan Zeng, Zeng Fan, Lin Chen, Wen Yue, Xiaoyan Xie, Xuetao Pei   +10 more
doaj   +1 more source

Relevance of anti‐thyroperoxidase antibodies in immune thrombocytopenia in adults: A single‐centre cohort study

British Journal of Haematology, EarlyView.
Nicolas Duhamel, Marie Ottavi, Sarah Lechtman, Nihal Martis, Charlotte Hinault‐Boyer, Julie Merindol, Pierre‐Yves Jeandel, Michael Levraut   +7 more
wiley   +1 more source