Results 51 to 60 of about 7,888 (191)

GATA1 in Normal and Pathologic Megakaryopoiesis and Platelet Development

Advances in Experimental Medicine and Biology
GATA1 is a highly conserved hematopoietic transcription factor (TF), essential for normal erythropoiesis and megakaryopoiesis, that encodes a full-length, predominant isoform and an amino (N) terminus-truncated isoform GATA1s.
K. Takasaki, Stella T. Chou
semanticscholar   +1 more source

Decreased Expression of IL‐35 and Its Receptor Contributes to Impaired Megakaryopoiesis in the Pathogenesis of Immune Thrombocytopenia

Advancement of science
Recent findings have shown that the level of interleukin‐35 (IL‐35) is abnormal in several autoimmune diseases. Nonetheless, whether IL‐35 participates in the pathogenesis of immune thrombocytopenia (ITP) remains unclear.
Xuan Cai, R.-Y. Gui, Jin Wu, Chen-cong Wang, Xiao-Lu Zhu, H. Fu, Xiao-Hui Zhang   +6 more
semanticscholar   +1 more source

Lineage tracing of Pf4-Cre marks hematopoietic stem cells and their progeny [PDF]

, 2012
The development of a megakaryocyte lineage specific Cre deleter, using the Pf4 (CXCL4) promoter (Pf4-Cre), was a significant step forward in the specific analysis of platelet and megakaryocyte cell biology.
Calaminus, Simon, Watson, Steve P., Tessa L. Holyoake, Guitart, Amelie V., Amelie V Guitart, Calaminus, Simon D J, Machesky, Laura, Schachtner, Hannah, Steve P Watson, Amelie V. Guitart, Amy Sinclair, Amelie Guitart, Kranc, Kamil R., Machesky, Laura M, Holyoake, Tessa L., Holyoake, Tessa L, Calaminus, Simon D.J., Steve P. Watson, Watson, Steve P, Guitart, Amelie, Machesky, Laura M., Simon D J Calaminus, Kranc, Kamil R, Watson, Steve, Laura M. Machesky, Holyoake, Tessa, Sinclair, Amy, Hannah Schachtner, Simon D. J. Calaminus, Laura M Machesky, Guitart, Amelie, V, Tessa L Holyoake, Kranc, Kamil, Kamil R. Kranc, Kamil R Kranc   +34 more
core   +1 more source

Ovarian cancer during pregnancy: Pregnancy‐adjusted inflammatory and haematologic signatures for earlier risk recognition and clinical decision‐making

Clinical and Translational Discovery, Volume 6, Issue 5, October 2026.
Pregnancy alters haematologic and inflammatory profiles, potentially masking ovarian cancer. Integrating trimester‐specific NLR, PLR, SII, CRP, CA‐125, haemoglobin, platelet dynamics, and imaging may improve risk stratification. Multimodal biomarkers, longitudinal monitoring, and multidisciplinary assessment can support earlier detection and ...
Emmanuel Ifeanyi Obeagu
wiley   +1 more source

PI3K/HSCB axis facilitates FOG1 nuclear translocation to promote erythropoiesis and megakaryopoiesis

bioRxiv
Erythropoiesis and megakaryopoiesis are stringently regulated by signaling pathways. However, the precise molecular mechanisms through which signaling pathways regulate key transcription factors controlling erythropoiesis and megakaryopoiesis remain ...
Gang Liu, Yunxuan Hou, Xin Jin, Yixue Zhang, Chaoyue Sun, Chengquan Huang, Yujie Ren, Jianmin Gao, Xiuli Wang, Xiumei Jiang   +9 more
semanticscholar   +1 more source

Dengue virus infection impedes megakaryopoiesis in MEG-01 cells where the virus envelope protein interacts with the transcription factor TAL-1

Scientific Reports, 2020
Dengue virus (DENV) infection causes dengue fever in humans, which can lead to thrombocytopenia showing a marked reduction in platelet counts, and dengue hemorrhagic fever.
A. Banerjee, A. Tripathi, Shweta Duggal, A. Banerjee, S. Vrati   +4 more
semanticscholar   +1 more source

Tanshinone Iia Inhibits Megakaryopoiesis in Immune Vasculitis

Blood, 2021
Introduction Tanshinone IIA, an active component of Danshen (Salvia miltiorrhiza), has been used for centuries to treat hypercoagulation-related diseases, which attributed to its anti-platelet and anti-inflammatory effects.
Hui Chen, Min Zhou, Hui-Ying Shu, Wei-Qing Su, Liuming Yang, Liang Li, Beng H. Chong, Mo Yang   +7 more
semanticscholar   +1 more source

The German ONKOPEDIA Guideline for Myelofibrosis in 2025—Recommendations of an MPN Expert Panel of the German Society for Hematology and Oncology (DGHO)

International Journal of Cancer, Volume 159, Issue 7, Page 1633-1641, 1 October 2026.
ABSTRACT The recently published ONKOPEDIA guideline on myelofibrosis, issued under the auspices of the German Society of Hematology and Oncology (DGHO), provides an updated, evidence‐based framework for the diagnosis and management of this rare, chronic myeloproliferative neoplasm.
Martin Griesshammer, Haifa Kathrin Al‐Ali, Gabriela M. Baerlocher, Konstanze Döhner, Steffen Koschmieder, Nicolaus Kröger, Petro E. Petrides, Dominik Wolf, Florian H. Heidel   +8 more
wiley   +1 more source

G2 arrest primes hematopoietic stem cells for megakaryopoiesis

Cell Reports
SUMMARY In contrast to most hematopoietic lineages, megakaryocytes (MKs) can derive rapidly and directly from hematopoietic stem cells (HSCs). The underlying mechanism is unclear, however. Here, we show that DNA damage induces MK markers in HSCs and that
Corey M. Garyn, Oriol Bover, John W. Murray, Jing Ma, Karen Salas-Briceno, Susan R. Ross, H. Snoeck   +6 more
semanticscholar   +1 more source

Aplastic Anaemia in a Chronic Lymphocytic Leukaemia Patient Treated With Acalabrutinib, a Bruton Tyrosine Kinase Inhibitor—Case Report

eJHaem, Volume 7, Issue 5, October 2026.
ABSTRACT Introduction Although Immune cytopenias such as immune thrombocytopenia (ITP), autoimmune haemolytic anaemia (AIHA) and pure red blood cell aplasia (PRCA) are well documented associations with chronic lymphocytic leukaemia (CLL), aplastic anaemia (AA) is seemingly rare. Case This report describes a case of AA in a CLL patient post commencement
Zachray Wei, Tamara Marconi, Lucy Tuck, Stephen Ting   +3 more
wiley   +1 more source