Results 71 to 80 of about 4,397 (174)

Hematological Indices as Biomarkers in Patients With Rheumatoid Arthritis but Normal ESR/CRP Receiving Biological/Targeted Synthetic DMARDs

International Journal of Rheumatic Diseases, Volume 29, Issue 7, July 2026.
ABSTRACT Objectives Evidence indicates that hematological indices, such as neutrophil‐to‐lymphocyte ratio (NLR), systemic immune‐inflammation index (SII), and neutrophil‐to‐hemoglobin and lymphocyte (NHL), are valuable for assessing disease activity in rheumatoid arthritis (RA).
Jyun‐Pei Jhou, Yin‐Hui Hou, Yu‐Sheng Chang, Jui‐Chia Chang, Wan‐Chen Shen   +4 more
wiley   +1 more source

The LAV‐BPIFB4‐Platelet‐CD47 Axis: A Novel Mechanism Associated With Immune Resilience in Longevity

Aging Cell, Volume 25, Issue 7, July 2026.
Centenarians display elevated CD47+ reticulated platelets, a trait recapitulated in LAV‐BPIFB4 carriers on total platelet pool. LAV‐BPIFB4 drives an early acquirement of CD47 surface expression, enabling platelets to suppress monocyte IL‐6 release. rhLAV‐BPIFB4 phenocopies the effects in non‐genetic carriers, establishing the platelet–CD47–monocyte ...
Elena Ciaglia, Roberta Maria Esposito, Valentina Lopardo, Francesco Montella, Cristina Basile, Roberta Longo, Anna Maciag, Giuseppe Rescigno, Antonio Damato, Francesco Del Plato, Alfonso Finizio, Carmine Vecchione, Albino Carrizzo, Annibale Alessandro Puca   +13 more
wiley   +1 more source

MicroRNAs as potential architects of immune dysregulation and megakaryocytic failure in immune thrombocytopenia

British Journal of Haematology, Volume 209, Issue 1, Page 16-27, July 2026.
Summary Immune thrombocytopenia (ITP) is a complex autoimmune disorder characterized by accelerated destruction of peripheral platelets and impaired megakaryopoiesis. While the cellular effectors, dysregulated T cells, hyperactive B cells and phagocytic macrophages are well characterized, the upstream epigenetic mechanisms orchestrating this ...
Zhenyu Liu, Johan Rebetz, Lamya Garabet, Waleed Ghanima, Peipei Xu, Hans Wadenvik, Drew Provan, Rick Kapur, John W. Semple   +8 more
wiley   +1 more source

High-Efficiency Enrichment of Megakaryocytes and Identification of Micromegakaryocytes from Human Bone Marrow by Imaging Flow Cytometry

Cells
Megakaryocytes (MKs) are rare, large, polyploid bone marrow (BM) cells responsible for the production of platelets. The identification and characterization of MKs is widely recognized as challenging.
Maya Nautrup Pedersen, Trine Engelbrecht Hybel, Jens Haugbølle Bjerre, Anne Sofie Borg Hammer, Anja Bille Bohn, Marie Bill, Carina Agerbo Rosenberg, Maja Ludvigsen   +7 more
doaj   +1 more source

C3G, through its GEF activity, induces megakaryocytic differentiation and proplatelet formation

Cell Communication and Signaling, 2018
Background Megakaryopoiesis allows platelet formation, which is necessary for coagulation, also playing an important role in different pathologies. However, this process remains to be fully characterized. C3G, an activator of Rap1 GTPases, is involved in
Sara Ortiz-Rivero, Cristina Baquero, Luis Hernández-Cano, Juan José Roldán-Etcheverry, Sara Gutiérrez-Herrero, Cristina Fernández-Infante, Víctor Martín-Granado, Eduardo Anguita, José María de Pereda, Almudena Porras, Carmen Guerrero   +10 more
doaj   +1 more source

The Microtubule Plus-End Tracking Protein CLASP2 Is Required for Hematopoiesis and Hematopoietic Stem Cell Maintenance

Cell Reports, 2012
Mammalian CLASPs are microtubule plus-end tracking proteins whose essential function as regulators of microtubule behavior has been studied mainly in cultured cells.
Ksenija Drabek, Laura Gutiérrez, Marcel Vermeij, Thomas Clapes, Sunita R. Patel, Jean-Charles Boisset, Jeffrey van Haren, Ana L. Pereira, Zhe Liu, Umut Akinci, Tatjana Nikolic, Wilfred van IJcken, Mirjam van den Hout, Marjolein Meinders, Clara Melo, Clara Sambade, Dubravka Drabek, Rudi W. Hendriks, Sjaak Philipsen, Mieke Mommaas, Frank Grosveld, Helder Maiato, Joseph E. Italiano, Jr., Catherine Robin, Niels Galjart   +24 more
doaj   +1 more source

This Is Not a Myeloproliferative Neoplasm…

Pediatric Blood &Cancer, Volume 73, Issue 7, July 2026.
Stephanie Juané Kennedy
wiley   +1 more source

THROMBOCYTOPENIA CAUSED BY INHERITED HAEMATOPOIETIC TRANSCRIPTION FACTOR MUTATION: CLINICAL PHENOTYPES AND DIAGNOSTIC CONSIDERATIONS

European Medical Journal Hematology, 2016
Inherited thrombocytopenias comprise a heterogeneous group of blood disorders with abnormalities in genes related to glycoproteins and adhesion molecules, signalling pathways, cytoskeletal components, granule formation, and transcription factor complexes.
David J. Rabbolini, Christopher M. Ward, William S. Stevenson   +2 more
doaj  

Bone marrow endothelial cell-derived interleukin-4 contributes to thrombocytopenia in acute myeloid leukemia

Haematologica, 2019
Normal hematopoiesis can be disrupted by the leukemic bone marrow microenvironment, which leads to cytopenia-associated symptoms including anemia, hemorrhage and infection.
Ai Gao, Yuemin Gong, Caiying Zhu, Wanzhu Yang, Qing Li, Mei Zhao, Shihui Ma, Jianyong Li, Sha Hao, Hui Cheng, Tao Cheng   +10 more
doaj   +1 more source

A Mad(2) modification modulating megakaryopoiesis [PDF]

Journal of Experimental Medicine, 2014
![Figure][1] Insight from Adam Goldfarb Megakaryocytes, the rare platelet-producing cells within the bone marrow, undergo an unusual developmental transition from early mitotic proliferation to endomitosis associated with polyploidization and enlargement.
openaire   +2 more sources