Results 71 to 80 of about 7,888 (191)
Osteoblasts support megakaryopoiesis through production of interleukin-9
, 2017 Key Points Osteoblast-produced IL-9 supports megakaryopoiesis and platelet formation. IL-9 is a promising therapeutic agent for treatment of thrombocytopenia.
Yongkui Wang +17 more
core +1 more source
Eltrombopag, a potent stimulator of megakaryopoiesis
Haematologica, 2016 In this issue of Haematologica , Di Buduo et al. show that eltrombopag induces human megakaryopoiesis in vitro and ex vivo through an activation of STAT, AKT and ERK pathways that is different from the other thrombomimetic, romiplostim.[1][1] Megakaryopoiesis is the process leading to ...
Hana Raslova +2 more
openaire +3 more sources
European Journal of Haematology, Volume 117, Issue 3, Page 662-672, September 2026.ABSTRACT Introduction Jacobsen syndrome, resulting from a terminal deletion of chromosome 11 (11q), may lead to an increased bleeding tendency due to low platelet counts or platelet dysfunction. Currently, information on bleeding tendency and platelet function in patients with nonterminal 11q‐aberrations such as larger deletions, interstitial 11q ...
Elise J. Huisman +10 more
wiley +1 more source
Phosphocholine derivative stimulates megakaryopoiesis
, 2011 Platelets are produced from megakaryocytes through complex events, megakaryopoiesis which includes increased nucleus numbers through the endomitosis (up to 128N) and cytoplasmic maturation leading to the production of proplatelets and release of ...
전미정
core +1 more source
Changes in Megakaryopoiesis over Ontogeny and their Implications in Health and Disease
Platelets, 2020 A growing body of research has made it increasingly clear that there are substantial biological differences between fetal/neonatal and adult megakaryopoiesis.
Patricia E. Davenport +2 more
semanticscholar +1 more source
A quantitative dissection of the DNA‐binding properties of pathogenic GATA1 mutants
The FEBS Journal, Volume 293, Issue 17, Page 5140-5144, September 2026.Transcription factor activity is influenced by cell context, accessibility of target sequences, and co‐factor recruitment. Quantitatively characterizing the consequences of individual mutations in the transcription factors or their target sequences remains technically challenging. Zambo et al. use mutant GATA1‐ATP2B4 binding to illustrate an innovation
Kaoru Takasaki
wiley +1 more source
FLI1 level during megakaryopoiesis affects thrombopoiesis and platelet biology
, 2017 Key PointsParis-Trousseau syndrome is solely a result of FLI1 hemizygous deletion, with ETS1 levels being normal. Elevated FLI1 levels in megakaryocytes do not interfere with and may enhance megakaryopoiesis.
Vincent Hayes +7 more
core +1 more source
What's Your Diagnosis? A Case of Extreme Thrombocytosis in a Dog
Veterinary Clinical Pathology, EarlyView.
Stephanie F. Anderson +5 more
wiley +1 more source
Advanced Science, Volume 13, Issue 48, 28 August 2026.ABSTRACT Genome‐wide association studies (GWAS) link the Tropomyosin 1 (Tpm1) locus to quantitative blood trait variation, but related mechanisms are unclear. Tpm1 encodes an actin‐binding protein that regulates actin filament diversity, cell adhesion, signaling, and actomyosin contractility.
Po‐Lun Kung +19 more
wiley +1 more source
Acute Myeloid Leukemia in a Patient With Xeroderma Pigmentosum: A Case Report
Clinical Case Reports, Volume 14, Issue 8, August 2026.ABSTRACT Acute myeloid leukemia may occur in patients with xeroderma pigmentosum at a younger age and can be associated with complex cytogenetics and poor treatment response, highlighting the importance of regular hematologic monitoring.
Mina Soryal +5 more
wiley +1 more source