Results 81 to 90 of about 4,397 (174)

Megakaryopoiesis

Clinical & Experimental Thrombosis and Hemostasis, 2014
Keiichi Tozawa, Yukako Ono-Uruga, Yumiko Matsubara   +2 more
openaire   +1 more source

P2Y12–P-selectin-mediated platelet activation in a murine model of dengue-associated thrombocytopeniaResearch in context

EBioMedicine
Summary: Background: Dengue virus (DENV) infection frequently leads to thrombocytopenia, a hallmark of severe disease. However, the underlying mechanisms remain incompletely defined.
Viviane Lima Batista, Jenniffer Ramos Martins, Angélica Samer Lallo Dias, Talita Cristina Martins Fonseca, Letícia Soldati Silva, Felipe Emanuel Oliveira Rocha, Pedro Augusto Carvalho Costa, Wallison Nunes Silva, Jessica Aparecida Barsalini Pereira, Arielle Teixeira Silva, Maria Luiza Canalis, Maisa Antunes, Pedro Pires Goulart Guimarães, Gustavo Batista Menezes, Adriano de Paula Sabino, Lirlândia Pires Sousa, Celso Martins Queiroz-Junior, Eugenio Damaceno Hottz, Mauro Martins Teixeira, Vivian Vasconcelos Costa   +19 more
doaj   +1 more source

Management of chronic immune thrombocytopenic purpura: targeting insufficient megakaryopoiesis as a novel therapeutic principle

Biologics: Targets & Therapy, 2010
Andreas Rank, Oliver Weigert, Helmut OstermannMedizinische Klinik III – Grosshadern, Klinikum der Ludwig Maximilians-Universitaet Munich, Munich, GermanyAbstract: Traditionally, anti-platelet autoantibodies accelerating platelet clearance from ...
Andreas Rank, Oliver Weigert, Helmut Ostermann   +2 more
doaj  

Megakaryopoiesis [PDF]

, 2020
openaire   +1 more source

A systems herbal-to-molecule and transcriptomic strategy identifies emodin as an ESR1-targeting phytochemical driving thrombopoiesis

Chinese Medicine
Radiation-induced thrombocytopenia (RIT) is a major dose-limiting toxicity of radiotherapy, for which effective pharmacological interventions remain limited.
Xiao Qi, Qinyao Li, Fengyu Li, Linglin Zhou, Qi Mo, Jing Zeng, Tianci Hu, Sheng Liu, Xinyue Mei, Min Wu, Xuejing Qiang, Qiyang Cheng, Anguo Wu, Xiaogang Zhou, Feihong Huang, Qiaozhi Wang, Peng Chen, Jianming Wu, Long Wang   +18 more
doaj   +1 more source

The Role of DIAPH1 in the Megakaryopoiesis

Le rôle de DIAPH1 dans la mégacaryopoïèse Les mégacaryocytes sont les précurseurs cellulaires hautement spécialisés qui produisent des plaquettes via des extensions cytoplasmiques appelées proplaquettes. La formation des proplaquettes exige de profonds changements dans l’organisation du cytosquelette: microtubules et actine.
openaire   +2 more sources

Redox Regulation of Megakaryocyte Differentiation and Platelet Biogenesis. [PDF]

Antioxidants (Basel)
Chung H, Shin E, Park T, Jeong H, Jung H, Bae ON, Noh JY.   +6 more
europepmc   +1 more source

The PI3K-AKT pathway mediates the imbalance of bone marrow macrophage polarization in patients with immune thrombocytopenia. [PDF]

J Transl Med
Shen MZ, Zhao HY, Yu YT, Mo XD, Fu HX, Wang Y, Zhang XH, Huang XJ, Kong Y.   +8 more
europepmc   +1 more source

Give megs a break: minor DNA stress, platelets in excess. [PDF]

Blood Adv
Kimmerlin Q, Strassel C.
europepmc   +1 more source

ATRA improves megakaryopoiesis in immune thrombocytopenia through up-regulating the HIF-1α/SPHK2/S1P pathway. [PDF]

Sci Adv
Huang QS, Xue J, Liu FQ, Chen Q, Zhang G, Sun XY, Wang C, Yang L, Hou Y, Li Y, Wang Q, Peng J, Hou M, Zhao X, Kong Y, Chang Y, Zhao X, Huang XJ, Zhang XH.   +18 more
europepmc   +1 more source