Results 81 to 90 of about 7,888 (191)
Clinical Case Reports, Volume 14, Issue 8, August 2026.ABSTRACT Gaucher disease is a rare autosomal recessive lysosomal storage disorder that is caused by a deficiency of the enzyme “β‐glucocerebrosidase”, leading to the accumulation of glucocerebroside within macrophages. It commonly presents with hepatosplenomegaly, cytopenias, and bone marrow infiltration.
Muhammad Waqas +9 more
wiley +1 more source
Acute and Chronic Leukemia in Sub‐Saharan Africa: A Systematic Review
Cancer Reports, Volume 9, Issue 8, August 2026.ABSTRACT Background The four primary subgroups of leukemia include chronic myeloid leukemia (CML), acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), and chronic lymphocytic leukemia (CLL). Very little is known about the regional variation of leukemia and subtypes in sub‐Saharan Africa (SSA).
Allwell A. Ayirebi +17 more
wiley +1 more source
P53 activation inhibits all types of hematopoietic progenitors and all stages of megakaryopoiesis.
, 2016 International audienceTP53 also known as p53 is a tumor suppressor gene mutated in a variety of cancers. P53 is involved in cell cycle, apoptosis and DNA repair mechanisms and is thus tightly controlled by many regulators.
Plo, Isabelle +13 more
core +1 more source
, 2023 SARS-CoV-2 infection causes a considerable inflammatory response coupled with impaired platelet reactivity, which can lead to platelet disorders recognized as negative prognostic factors in COVID-19 patients.
Silvana Mirella Aliberti +17 more
core +1 more source
Abnormal splenic megakaryopoiesis in MPSV-induced myeloproliferative disease.
, 1987 peer reviewedThe myeloproliferative sarcoma virus (MPSV) induces a murine myeloproliferative syndrome characterized by an erythromyelemia, an anemia, a thrombocytopenia associated with a myeloproliferation in the spleen and a splenic and medullar ...
Jasmin, C. +8 more
core +1 more source
VEGFR-3 is expressed on megakaryocyte precursors in the murine bone marrow and plays a regulatory role in megakaryopoiesis. [PDF]
, 2012 VEGFR-3 is a transmembrane receptor tyrosine kinase that is activated by its ligands VEGF-C and VEGF-D. Although VEGFR-3 has been linked primarily to the regulation of lymphangiogenesis, in the present study, we demonstrate a role for VEGFR-3 in ...
Rothley, Melanie +8 more
core +1 more source
The role of platelet-derived molecules: PDGF and serotonin in the regulation of megakaryopoiesis
, 2011 Investigations on platelet-derived growth factor (PDGF) and serotonin (5-HT), molecules stored in platelet granules, imply their potential effects in regulating megakaryopoiesis, which also intimates the existence of an autocrine and/or paracrine loop ...
叶洁瑜., Ye, Jieyu.
core +1 more source
Role of the cellular microenvironment in megakaryopoiesis
, 2019 Les plaquettes sanguines ont comme rôle principal d’arrêter les saignements. Elles sont produites dans la moelle osseuse par des mégacaryocytes (MK) qui proviennent de la différenciation des cellules souches hématopoïétiques (CSH). L’objectif de ma thèse
Jost, Camille
core
Abnormal megakaryopoiesis and platelet function in cyclooxygenase-2-deficient mice
, 2015 Previous studies suggest that cyclooxygenase-2 (COX-2) might influence megakaryocyte (MK) maturation and platelet production in vitro. Using a gene deletion model, we analysed the effect of COX-2 deficiency on megakaryopoiesis and platelet function.
Petrucci, Giovanna +2 more
core +1 more source