Results 61 to 70 of about 7,888 (191)
Apocynin Prevents Abnormal Megakaryopoiesis and Platelet Activation Induced by Chronic Stress [PDF]
, 2017 Environmental chronic stress (ECS) has been identified as a trigger of acute coronary syndromes (ACS). Changes in redox balance, enhanced reactive oxygen species (ROS) production, and platelet hyperreactivity were detected in both ECS and ACS.
Alessandro Ieraci +11 more
core +1 more source
Aging Cell, Volume 25, Issue 10, October 2026.Dietary CoQ10 improves megakaryocyte maturation and polyploidization and reduces platelet hyperreactivity in naturally aged mice, while experiments in senescent Meg‐01 cells demonstrate enhanced autophagic flux and identify COPS3 as a contributing, but not, mediator.
Yixuan Xu +9 more
wiley +1 more source
Genomic landscape of megakaryopoiesis and platelet function defects [PDF]
, 2016 Megakaryopoiesis is a complex, stepwise process that takes place largely in the bone marrow. At the apex of the hierarchy, hematopoietic stem cells undergo a number of lineage commitment decisions that ultimately lead to the production of polyploid ...
BIANCHI, Elisa +4 more
core +1 more source
Historical review: megakaryopoiesis and thrombopoiesis [PDF]
Blood, 2008 Abstract The study of thrombopoiesis has evolved greatly since an era when platelets were termed “the dust of the blood,” only about 100 years ago. During this time megakaryocytes were identified as the origin of blood platelets; marrow-derived megakaryocytic progenitor cells were functionally defined and then purified; and the primary ...
openaire +2 more sources
Molecular TherapySepsis-induced thrombocytopenia (SIT) is a widely accepted predictor of poor prognosis during sepsis, while the mechanism of SIT remains elusive. In this study, we revealed that SIT patients and septic mice exhibited higher levels of pro-inflammatory ...
Zi-Yan Zhang +17 more
semanticscholar +1 more source
Regulation of megakaryopoiesis by bone marrow macrophage polarization
Blood Science, 2021 Immune thrombocytopenia (ITP) is an autoimmune disorder characterized by increased bleeding tendency and thrombocytopenia. The main mechanisms include the loss of immune tolerance, accelerated platelet destruction, impaired bone marrow (BM ...
M. Hou
semanticscholar +1 more source
Synthetic glycosaminoglycan mimetics as regulators of megakaryopoiesis and thrombopoiesis
, 2022 Data management plan for the grant, "Synthetic glycosaminoglycan mimetics as regulators of megakaryopoiesis and ...
Afosah, Daniel
core
Pairing megakaryopoiesis methylation with PEAR1 [PDF]
Blood, 2016 In this issue of Blood, Izzi et al pair a platelet function–associated single-nucleotide polymorphism (SNP) with allele-specific methylation at a cytosine guanine dinucleotide (CpG) island and regulation of platelet endothelial aggregation receptor 1 (PEAR1) RNA expression in megakaryopoiesis, describing one of the first epigenetic-SNP links to ...
openaire +2 more sources
Pediatric Anesthesia, Volume 36, Issue 9, Page 1132-1142, September 2026.ABSTRACT Introduction Emergence agitation (EA) is a postoperative neurobehavioral complication characterized by a transient disturbance in cognition and perception following anesthesia. Neuroinflammation is thought to play a central role in its pathophysiology.
Nezahat Merve Ata Soylu +6 more
wiley +1 more source