Results 1 to 10 of about 4,192 (175)

Altered thrombopoiesis in spontaneously hypertensive rats [PDF]

Scientific Reports
Platelet hyperreactivity is a risk factor for cardiovascular disease development and mortality in hypertensive patients. Although several studies have linked platelet hyperreactivity with increased bone marrow thrombopoiesis, extramedullary ...
Isaac Rojo, Diana Millán-Aldaco, Ruth Rincón-Heredia, Ivette Martínez-Vieyra, Victor Rosales-García, Gamaliel Aztatzi-Aguilar, Nury Pérez-Hernández, Arturo Hernández-Cruz, Doris Cerecedo   +8 more
doaj   +4 more sources

Application and investigation of thrombopoiesis-stimulating agents in the treatment of thrombocytopenia

Therapeutic Advances in Hematology, 2023
Platelets, derived from a certain subpopulation of megakaryocytes, are closely related to hemostasis, coagulation, metastasis, inflammation, and cancer progression.
Qing Lin, Yiyue Zhang, Lejun Huang
exaly   +2 more sources

Apoptosis in megakaryocytes: Safeguard and threat for thrombopoiesis

Frontiers in Immunology, 2023
Platelets, generated from precursor megakaryocytes (MKs), are central mediators of hemostasis and thrombosis. The process of thrombopoiesis is extremely complex, regulated by multiple factors, and related to many cellular events including apoptosis ...
Jianming Wu, An-Guo Wu, Fahsai Kantawong   +2 more
exaly   +3 more sources

CD11c⁺ Cells Control Platelet Homeostasis in a Murine Bone Marrow Chimeric Atherosclerosis Model [PDF]

Biomedicines
Background/Objectives: Dendritic cells (DCs) are key regulators of immune responses in cardiovascular disease, yet their role in platelet homeostasis and thrombopoiesis remains incompletely understood. We previously demonstrated that chronic depletion of
Manuela Sauter, Serena Gregori, Harald F. Langer, Reinhard J. Sauter   +3 more
doaj   +2 more sources

Temporal Lysophosphatidic Acid Supplementation Enhances Megakaryocyte Differentiation and Platelet Production From Human Hematopoietic Progenitors. [PDF]

Cell Biol Int
ABSTRACT Platelet shortages and limited storage stability restrict global platelet transfusion capacity, highlighting the need for efficient in vitro platelet production systems. This study establishes a simple, non‐genetic and cost‐effective system for efficient in vitro platelet‐like particle (PLP) production from human hematopoietic stem/progenitor ...
Jiamvoraphong N, Lorthongpanich C, Septham P, Klaihmon P, Kheolamai P, Laowtammathron C, Imsoonthornruksa S, Ketudat-Cairns M, Issaragrisil S.   +8 more
europepmc   +2 more sources

Pulmonary Embolism in a Patient with Dual Inferior Vena Cava [PDF]

TH Open
Dual inferior vena cava (DIVC) is a rare congenital anomaly complicating venous thromboembolism (VTE) management. This report describes a 59-year-old male with right lower extremity deep vein thrombosis and extensive pulmonary embolism.
Huaqiang Fang, Kanghui Dai, Xianhua Zhu, Zishan Deng, Jiehua Qiu   +4 more
doaj   +2 more sources

Thrombocytopenia in dengue infection: mechanisms and a potential application [PDF]

Expert Reviews in Molecular Medicine
Thrombocytopenia is a common symptom and one of the warning signs of dengue virus (DENV) infection. Platelet depletion is critical as it may lead to other severe dengue symptoms.
Ahmad Suhail Khazali, Waqiyuddin Hilmi Hadrawi, Fatimah Ibrahim, Shatrah Othman, Nurshamimi Nor Rashid   +4 more
doaj   +2 more sources

α-Actinin-1 in Megakaryocytes: Its Structure, Interacting Proteins and Implications for Thrombopoiesis [PDF]

Biomedicines
Mutations in the ACTN1 gene, which encodes the cytoskeletal protein α-actinin-1, have been implicated in the etiology of autosomal dominant congenital macrothrombocytopenia.
Lanlan Wu, Zhiqun Song, Yulan Zhou, Jiansong Huang, Xiaoxia Huang   +4 more
doaj   +2 more sources

Beyond energy: Mitochondrial control of platelet lifecycle through redox, calcium, and dynamics [PDF]

Redox Biology
Platelet disorders, caused by quantitative deficiencies or functional impairments, significantly contribute to cardiovascular, neurological, and iatrogenic pathologies. Although platelets are indispensable for hemostasis, thrombosis, and immune responses,
Xinle Wang, Rui Liao, Qihang Huang, Jingyan Li, Xiang Li, Xiaolin Gan, Yiwei Wang, Chunling Zhao, Qibing Mei, Jianping Chen, Anguo Wu, Xiaogang Zhou, Jianming Wu   +12 more
doaj   +2 more sources

Enhanced thrombopoiesis supplies PD-L1 to circulating immune cells via the generation of PD-L1-expressing platelets in patients with lung cancer [PDF]

Journal for ImmunoTherapy of Cancer
Background The increased expression of programmed cell death ligand 1 (PD-L1) on a subset of immune cells in the peripheral blood has been frequently observed in patients with cancer, suggesting a relationship with PD-L1 expression in tumor tissues.
Sung-Woo Lee, Ju Sik Yun, Hyun-Ju Cho, In-Jae Oh, Deok Hwan Yang, Jae-Ho Cho, Eu Chang Hwang, Young Ju Kim, Woo Kyun Bae, Saei Jeong, Jeong Eun Noh, Kyung Na Rho, Hee-Ok Kim, Sook Jung Yun, Cheol-Kyu Park   +14 more
doaj   +2 more sources