Results 1 to 10 of about 4,330 (114)
Apoptosis in megakaryocytes: Safeguard and threat for thrombopoiesis
Frontiers in Immunology, 2023 Platelets, generated from precursor megakaryocytes (MKs), are central mediators of hemostasis and thrombosis. The process of thrombopoiesis is extremely complex, regulated by multiple factors, and related to many cellular events including apoptosis ...
Songyot Anuchapreeda +2 more
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Therapeutic Advances in Hematology, 2023 Platelets, derived from a certain subpopulation of megakaryocytes, are closely related to hemostasis, coagulation, metastasis, inflammation, and cancer progression.
Qing Lin, Yiyue Zhang, Lejun Huang
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Altered thrombopoiesis in spontaneously hypertensive rats [PDF]
Scientific ReportsPlatelet hyperreactivity is a risk factor for cardiovascular disease development and mortality in hypertensive patients. Although several studies have linked platelet hyperreactivity with increased bone marrow thrombopoiesis, extramedullary ...
Isaac Rojo +8 more
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CD11c+ Cells Control Platelet Homeostasis in a Murine Bone Marrow Chimeric Atherosclerosis Model [PDF]
BiomedicinesBackground/Objectives: Dendritic cells (DCs) are key regulators of immune responses in cardiovascular disease, yet their role in platelet homeostasis and thrombopoiesis remains incompletely understood. We previously demonstrated that chronic depletion of
Manuela Sauter +3 more
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α-Actinin-1 in Megakaryocytes: Its Structure, Interacting Proteins and Implications for Thrombopoiesis [PDF]
BiomedicinesMutations in the ACTN1 gene, which encodes the cytoskeletal protein α-actinin-1, have been implicated in the etiology of autosomal dominant congenital macrothrombocytopenia.
Lanlan Wu +4 more
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Enhanced thrombopoiesis supplies PD-L1 to circulating immune cells via the generation of PD-L1-expressing platelets in patients with lung cancer [PDF]
Journal for ImmunoTherapy of CancerBackground The increased expression of programmed cell death ligand 1 (PD-L1) on a subset of immune cells in the peripheral blood has been frequently observed in patients with cancer, suggesting a relationship with PD-L1 expression in tumor tissues.
Sung-Woo Lee +14 more
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Cells, 2023 Platelets are generated by specialized cells called megakaryocytes (MKs). However, MK’s origin and platelet release mode have remained incompletely understood.
Huan Liu +7 more
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Particle and Fibre Toxicology, 2021 Background Although airborne fine particulate matter (PM) pollution has been demonstrated as an independent risk factor for pulmonary and cardiovascular diseases, their currently-available toxicological data is still far from sufficient to explain the ...
Xiaoting Jin +8 more
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Highly efficient platelet generation in lung vasculature reproduced by microfluidics
Nature Communications, 2023 Platelets, small hemostatic blood cells, are derived from megakaryocytes. Both bone marrow and lung are principal sites of thrombopoiesis although underlying mechanisms remain unclear.
Xiaojuan Zhao +20 more
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Nature Communications, 2020 Mutations affecting sialylation and galactosylation affect megakaryocyte function and thrombopoiesis. Here the authors show that the enzyme β4GalT1 regulates thrombopoiesis and hematopoietic stem cell homeostasis by controlling beta-1 integrin function.
Silvia Giannini +8 more
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