Results 31 to 40 of about 4,399 (180)

New-onset acute thrombocytopenia in hospitalized patients: pathophysiology and diagnostic approach

Journal of Community Hospital Internal Medicine Perspectives, 2017
Thrombocytopenia is a hematological finding commonly encountered in daily clinical practice from asymptomatic clinic patients to critically ill intensive care unit patients.
Naveed Ali, Herbert E. Auerbach
doaj   +1 more source

Commonalities of platelet dysfunction in heart failure with preserved ejection fraction and underlying comorbidities

ESC Heart Failure, Volume 12, Issue 2, Page 1013-1028, April 2025.
Abstract Heart failure with preserved ejection fraction (HFpEF) is characterized by a lack of a specific targeted treatment and a complex, partially unexplored pathophysiology. Common comorbidities associated with HFpEF are hypertension, atrial fibrillation, obesity and diabetes.
Giorgia D'Italia, Blanche Schroen, Judith M.E.M. Cosemans   +2 more
wiley   +1 more source

From Hematopoietic Stem Cells to Platelets: Unifying Differentiation Pathways Identified by Lineage Tracing Mouse Models

Cells
Platelets are the terminal progeny of megakaryocytes, primarily produced in the bone marrow, and play critical roles in blood homeostasis, clotting, and wound healing.
Bryce A. Manso, Alessandra Rodriguez y Baena, E. Camilla Forsberg   +2 more
doaj   +1 more source

Development and External Validation of a Postoperative Risk Score for Venous Thromboembolism in Epithelial Ovarian Cancer

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Venous thromboembolism (VTE), including deep vein thrombosis and pulmonary embolism, is a major complication in women with epithelial ovarian cancer (EOC). We aimed to develop and externally validate an early postoperative risk score to identify EOC patients at increased risk of VTE after debulking surgery.
Qiu‐Lin Cui, Yu‐Shi He, Xuan‐Hui Wang, Cheng Li, Gang Wang, Ming Chen, Shu‐Min Chen   +6 more
wiley   +1 more source

Piggyback knockdown screening of unique genes of zebrafish young thrombocytes identifies eight novel genes in thrombopoiesis

Scientific Reports
Platelet production, or thrombopoiesis, is a critical process involving the differentiation of hematopoietic stem cells into megakaryocytes, which release platelets into circulation.
Weam Fallatah, Jabila Mary, Sanchi Dhinoja, Sravani Vallabhaneni, Pudur Jagadeeswaran   +4 more
doaj   +1 more source

Increased anergic B cells and decreased antibody‐secreting cells during romiplostim treatment in patients with immune thrombocytopenia

British Journal of Haematology, EarlyView.
Summary Patients with immune thrombocytopenia (ITP) exhibit substantial heterogeneity in treatment responses. Approximately 30%–50% of patients maintain remission after discontinuation of thrombopoietin receptor agonists (TPO‐RA), suggesting immunomodulatory effects beyond enhanced thrombopoiesis.
Vivianne S. Nelson, Rebeca Gutiérrez‐Cózar, Rebecca Cornelis, S. Marieke van Ham, Anja ten Brinke, Rick Kapur   +5 more
wiley   +1 more source

Pulmonary Embolism in a Patient with Dual Inferior Vena Cava

TH Open
Dual inferior vena cava (DIVC) is a rare congenital anomaly complicating venous thromboembolism (VTE) management. This report describes a 59-year-old male with right lower extremity deep vein thrombosis and extensive pulmonary embolism.
Huaqiang Fang, Kanghui Dai, Xianhua Zhu, Zishan Deng, Jiehua Qiu   +4 more
doaj   +1 more source

Dynamic Regulation of a Ribosome Rescue Pathway in Erythroid Cells and Platelets

Cell Reports, 2016
Protein synthesis continues in platelets and maturing reticulocytes, although these blood cells lack nuclei and do not make new mRNA or ribosomes. Here, we analyze translation in primary human cells from anucleate lineages by ribosome profiling and ...
Eric W. Mills, Jamie Wangen, Rachel Green, Nicholas T. Ingolia   +3 more
doaj   +1 more source

Persistent janus kinase‐signaling in chronic lymphocytic leukemia patients on ibrutinib: Results of a phase I trial

Cancer Medicine, 2019
Methods to deepen clinical responses to ibrutinib are needed to improve outcomes for patients with chronic lymphocytic leukemia (CLL). This study aimed to determine the safety and efficacy of combining a janus kinase (JAK)‐inhibitor with ibrutinib ...
David E. Spaner, Lindsay McCaw, Guizhei Wang, Hubert Tsui, Yonghong Shi   +4 more
doaj   +1 more source

Roles of non-coding RNA in megakaryocytopoiesis and thrombopoiesis: new target therapies in ITP

Platelets, 2023
Noncoding RNAs (ncRNAs) are a group of RNA molecules that cannot encode proteins, and a better understanding of the complex interaction networks coordinated by ncRNAs will provide a theoretical basis for the development of therapeutics targeting the ...
Wuquan Li, Yan Lv, Yeying Sun
doaj   +1 more source