Results 21 to 30 of about 4,192 (175)

Kinetics of thrombopoiesis [PDF]

Journal of Clinical Investigation, 1968
Measurements of megakaryocyte number, volume, nuclear number, and cytoplasmic granulation were compared in animals with induced thrombocytosis, normal platelet counts, and induced thrombocytopenia for 4- and 10-day periods. Thrombopoiesis, as measured by megakaryocytic mass and (35)S incorporation into platelets, appeared to be regulated by the demand ...
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Chemically modified in-vitro-transcribed mRNA encoding thrombopoietin stimulates thrombopoiesis in mice

Molecular Therapy: Nucleic Acids, 2022
The use of messenger RNA (mRNA) enables the transient production of therapeutic proteins with stable and predictable translational kinetics and without the risk of insertional mutagenesis.
Yu Zhang, Xiaodong Xi, Hang Yu, Liuyan Yang, Jinzhong Lin, Wen Yang, Junling Liu, Xuemei Fan, Yingjie Xu   +8 more
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Haematopoietic thrombocyte precursors in rat femoral and sternal bone marrow

Bulgarian Journal of Veterinary Medicine, 2021
This research presents the first findings on thrombopoiesis for Wistar rats. Haemopoietic cells from the femur and the sternum were analysed by light microscopy in combination with infrared and near-ultraviolet light for fine cytoplasmic structure ...
D. Suljević, A. Hamzić, E. Islamagić, E. Fejzić , A. Alijagić   +4 more
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Targeting a thrombopoietin-independent strategy in the discovery of a novel inducer of megakaryocytopoiesis, DMAG, for the treatment of thrombocytopenia

Haematologica, 2022
Thrombocytopenia is a thrombopoietin (TPO)-related disorder with very limited treatment options, and can be lifethreatening. There are major problems with typical thrombopoietic agents targeting TPO signaling, so it is urgent to discover a novel TPO ...
Long Wang, Sha Liu, Jiesi Luo, Qi Mo, Mei Ran, Ting Zhang, Xiaoxuan Li, Wenjun Zou, Qibing Mei, Jianping Chen, Jing Yang, Jing Zeng, Feihong Huang, Anguo Wu, Chunxiang Zhang, Jianming Wu   +15 more
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Immature Platelet Counts and Thrombopoietin Plasma Concentrations in Thrombocytopenic and Non-thrombocytopenic Preterm Infants

Frontiers in Pediatrics, 2021
Objective: Immature platelet counts (IPC) may prove useful in guiding platelet transfusion management in preterm neonates. However, the relationship between IPCs and thrombopoietin (Tpo) concentrations has not been evaluated in preterm neonates.Methods ...
Hannes Sallmon, Hannes Sallmon, Hannes Sallmon, Andreas Weimann, Christoph Bührer, Boris Metze, Christof Dame, Malte Cremer   +7 more
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Caulis Polygoni Multiflori Accelerates Megakaryopoiesis and Thrombopoiesis via Activating PI3K/Akt and MEK/ERK Signaling Pathways

Pharmaceuticals, 2022
Thrombocytopenia is one of the most common complications of cancer therapy. Until now, there are still no satisfactory medications to treat chemotherapy and radiation-induced thrombocytopenia (CIT and RIT, respectively). Caulis Polygoni Multiflori (CPM),
Xin Yang, Long Wang, Jing Zeng, Anguo Wu, Mi Qin, Min Wen, Ting Zhang, Wang Chen, Qibing Mei, Dalian Qin, Jing Yang, Yu Jiang, Jianming Wu   +12 more
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CK2: a key regulator of thrombopoiesis [PDF]

Blood, 2017
In this issue of Blood, Munzer et al used a specific platelet/megakaryocyte (MK) deletion of casein kinase (CK) 2β mouse model to elegantly demonstrate that CK2 regulates both platelet formation and activation by altering microtubule structure, which results in impaired intracellular Ca2+ release ...
William, Vainchenker, Hana, Raslova
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Research progress of methodological techniques of generation of platelets from induced pluripotent stem cells in vitro

Zhongguo shuxue zazhi, 2023
Platelets play a role in hemostasis in vivo, and platelet transfusion is the main means to treat bleeding diseases caused by thrombocytopenia or platelet dysfunction.
Wei YUE, Haihui GU
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Intravital imaging of megakaryocytes

Platelets, 2020
The dynamics of platelet formation could only be investigated since the development of two-photon microscopy in combination with suitable fluorescent labeling strategies.
David Stegner, Katrin G. Heinze
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ROS: novel regulators of thrombopoiesis [PDF]

Blood, 2016
In this issue of Blood, Wu et al describe a novel dominant negative loss-of-function mutation (BLVRB S111L) in a heme catabolic pathway deregulating reactive oxygen species (ROS) and associated with thrombocytosis ...
Bing Zhang, James L. Zehnder
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