Results 21 to 30 of about 4,128 (175)

Haematopoietic thrombocyte precursors in rat femoral and sternal bone marrow

Bulgarian Journal of Veterinary Medicine, 2021
This research presents the first findings on thrombopoiesis for Wistar rats. Haemopoietic cells from the femur and the sternum were analysed by light microscopy in combination with infrared and near-ultraviolet light for fine cytoplasmic structure ...
D. Suljević, A. Hamzić, E. Islamagić, E. Fejzić , A. Alijagić   +4 more
doaj   +1 more source

Targeting a thrombopoietin-independent strategy in the discovery of a novel inducer of megakaryocytopoiesis, DMAG, for the treatment of thrombocytopenia

Haematologica, 2022
Thrombocytopenia is a thrombopoietin (TPO)-related disorder with very limited treatment options, and can be lifethreatening. There are major problems with typical thrombopoietic agents targeting TPO signaling, so it is urgent to discover a novel TPO ...
Long Wang, Sha Liu, Jiesi Luo, Qi Mo, Mei Ran, Ting Zhang, Xiaoxuan Li, Wenjun Zou, Qibing Mei, Jianping Chen, Jing Yang, Jing Zeng, Feihong Huang, Anguo Wu, Chunxiang Zhang, Jianming Wu   +15 more
doaj   +1 more source

Immature Platelet Counts and Thrombopoietin Plasma Concentrations in Thrombocytopenic and Non-thrombocytopenic Preterm Infants

Frontiers in Pediatrics, 2021
Objective: Immature platelet counts (IPC) may prove useful in guiding platelet transfusion management in preterm neonates. However, the relationship between IPCs and thrombopoietin (Tpo) concentrations has not been evaluated in preterm neonates.Methods ...
Hannes Sallmon, Hannes Sallmon, Hannes Sallmon, Andreas Weimann, Christoph Bührer, Boris Metze, Christof Dame, Malte Cremer   +7 more
doaj   +1 more source

Caulis Polygoni Multiflori Accelerates Megakaryopoiesis and Thrombopoiesis via Activating PI3K/Akt and MEK/ERK Signaling Pathways

Pharmaceuticals, 2022
Thrombocytopenia is one of the most common complications of cancer therapy. Until now, there are still no satisfactory medications to treat chemotherapy and radiation-induced thrombocytopenia (CIT and RIT, respectively). Caulis Polygoni Multiflori (CPM),
Xin Yang, Long Wang, Jing Zeng, Anguo Wu, Mi Qin, Min Wen, Ting Zhang, Wang Chen, Qibing Mei, Dalian Qin, Jing Yang, Yu Jiang, Jianming Wu   +12 more
doaj   +1 more source

CK2: a key regulator of thrombopoiesis [PDF]

Blood, 2017
In this issue of Blood, Munzer et al used a specific platelet/megakaryocyte (MK) deletion of casein kinase (CK) 2β mouse model to elegantly demonstrate that CK2 regulates both platelet formation and activation by altering microtubule structure, which results in impaired intracellular Ca2+ release ...
William, Vainchenker, Hana, Raslova
openaire   +2 more sources

Research progress of methodological techniques of generation of platelets from induced pluripotent stem cells in vitro

Zhongguo shuxue zazhi, 2023
Platelets play a role in hemostasis in vivo, and platelet transfusion is the main means to treat bleeding diseases caused by thrombocytopenia or platelet dysfunction.
Wei YUE, Haihui GU
doaj   +1 more source

Dopamine induces platelet production from megakaryocytes via oxidative stress-mediated signaling pathways

Platelets, 2018
Dopamine (DA), a catecholamine neurotransmitter, is known to for its diverse roles on hematopoiesis, yet its function in thrombopoiesis remains poorly understood.
Shilei Chen, Mengjia Hu, Mingqiang Shen, Yang Xu, Cheng Wang, Xinmiao Wang, Fengju Li, Dongfeng Zeng, Fang Chen, Gaomei Zhao, Mo Chen, Fengchao Wang, Tianmin Cheng, Yongping Su, Jinghong Zhao, Song Wang, Junping Wang   +16 more
doaj   +1 more source

Dynamic Regulation of a Ribosome Rescue Pathway in Erythroid Cells and Platelets

Cell Reports, 2016
Protein synthesis continues in platelets and maturing reticulocytes, although these blood cells lack nuclei and do not make new mRNA or ribosomes. Here, we analyze translation in primary human cells from anucleate lineages by ribosome profiling and ...
Eric W. Mills, Jamie Wangen, Rachel Green, Nicholas T. Ingolia   +3 more
doaj   +1 more source

Toll-like Receptors and Thrombopoiesis

International Journal of Molecular Sciences, 2023
Platelets are the second most abundant blood component after red blood cells and can participate in a variety of physiological and pathological functions. Beyond its traditional role in hemostasis and thrombosis, it also plays an indispensable role in inflammatory diseases. However, thrombocytopenia is a common hematologic problem in the clinic, and it
Xiaoqin Tang, Qian Xu, Shuo Yang, Xinwu Huang, Long Wang, Feihong Huang, Jiesi Luo, Xiaogang Zhou, Anguo Wu, Qibing Mei, Chunling Zhao, Jianming Wu   +11 more
openaire   +2 more sources

ROS: novel regulators of thrombopoiesis [PDF]

Blood, 2016
In this issue of Blood, Wu et al describe a novel dominant negative loss-of-function mutation (BLVRB S111L) in a heme catabolic pathway deregulating reactive oxygen species (ROS) and associated with thrombocytosis ...
Bing Zhang, James L. Zehnder
openaire   +2 more sources