Results 11 to 20 of about 4,128 (175)
Temporal Lysophosphatidic Acid Supplementation Enhances Megakaryocyte Differentiation and Platelet Production From Human Hematopoietic Progenitors. [PDF]
Cell Biol IntABSTRACT Platelet shortages and limited storage stability restrict global platelet transfusion capacity, highlighting the need for efficient in vitro platelet production systems. This study establishes a simple, non‐genetic and cost‐effective system for efficient in vitro platelet‐like particle (PLP) production from human hematopoietic stem/progenitor ...
Jiamvoraphong N +8 more
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Mechanisms of thrombopoiesis [PDF]
Journal of Thrombosis and Haemostasis, 2005 Megakaryocytes (MKs) expand and differentiate over several days in response to thrombopoietin (Tpo) before releasing innumerable blood platelets. The final steps in platelet assembly and release represent a unique cellular transformation that is orchestrated by a range of transcription factors, signaling molecules, and cytoskeletal elements.
H, Schulze, R A, Shivdasani
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Studies on Thrombopoiesis [PDF]
Blood, 1957 Abstract Thrombocytopoiesis was studied by direct, continuous observation in tissue cultures of bone marrows taken from three patients with chronic idiopathic thrombocytopenic purpura and from normals following the addition of a potent anti-platelet serum to the culture media. The process of platelet production was similar
G. IZAK, D. NELKEN, MISS A. HERZOG
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Highly efficient platelet generation in lung vasculature reproduced by microfluidics
Nature Communications, 2023 Platelets, small hemostatic blood cells, are derived from megakaryocytes. Both bone marrow and lung are principal sites of thrombopoiesis although underlying mechanisms remain unclear.
Xiaojuan Zhao +20 more
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Nature Communications, 2020 Mutations affecting sialylation and galactosylation affect megakaryocyte function and thrombopoiesis. Here the authors show that the enzyme β4GalT1 regulates thrombopoiesis and hematopoietic stem cell homeostasis by controlling beta-1 integrin function.
Silvia Giannini +8 more
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Molecular Therapy: Nucleic Acids, 2022 The use of messenger RNA (mRNA) enables the transient production of therapeutic proteins with stable and predictable translational kinetics and without the risk of insertional mutagenesis.
Yu Zhang +8 more
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Journal of Hematology & Oncology, 2023 Hyperhomocysteinemia (HHcy) is closely associated with thrombotic diseases such as myocardial infarction and stroke. Enhanced platelet activation was observed in animals and humans with HHcy.
Wenjing Lei +14 more
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The ABC of Thrombopoiesis [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2014 Platelets play an important role in atherogenesis and atherothrombosis. At early stages of atherosclerosis, platelet-borne chemokines and platelet–leukocyte complexes contribute to the recruitment of neutrophils and monocytes to inflamed arteries.1,2 At late stages, platelets orchestrate additional processes such as thrombosis by direct mechanisms and ...
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Kinetics of thrombopoiesis [PDF]
Journal of Clinical Investigation, 1968 Measurements of megakaryocyte number, volume, nuclear number, and cytoplasmic granulation were compared in animals with induced thrombocytosis, normal platelet counts, and induced thrombocytopenia for 4- and 10-day periods. Thrombopoiesis, as measured by megakaryocytic mass and (35)S incorporation into platelets, appeared to be regulated by the demand ...
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Cells, 2021 Careful morphological investigations, coupled with experimental hematology studies in animal models and in in vitro human cultures, have identified that platelets are released in the circulation by mature megakaryocytes generated by hematopoietic stem ...
Anna Rita Migliaccio
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