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The bone marrow is the primary site of thrombopoiesis
BloodAbstractMegakaryocytes (MKs) generate thousands of platelets over their lifespan. The roles of platelets in infection and inflammation has guided an interest to the study of extramedullary thrombopoiesis and therefore MKs have been increasingly reported within the spleen and lung.
Joseph Italiano +2 more
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Cells, 2023 Platelets are generated by specialized cells called megakaryocytes (MKs). However, MK’s origin and platelet release mode have remained incompletely understood.
Huan Liu +7 more
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Mechanisms of thrombopoiesis [PDF]
Journal of Thrombosis and Haemostasis, 2005 Megakaryocytes (MKs) expand and differentiate over several days in response to thrombopoietin (Tpo) before releasing innumerable blood platelets. The final steps in platelet assembly and release represent a unique cellular transformation that is orchestrated by a range of transcription factors, signaling molecules, and cytoskeletal elements.
H, Schulze, R A, Shivdasani
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Studies on Thrombopoiesis [PDF]
Blood, 1957 Abstract Thrombocytopoiesis was studied by direct, continuous observation in tissue cultures of bone marrows taken from three patients with chronic idiopathic thrombocytopenic purpura and from normals following the addition of a potent anti-platelet serum to the culture media. The process of platelet production was similar
G. IZAK, D. NELKEN, MISS A. HERZOG
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Particle and Fibre Toxicology, 2021 Background Although airborne fine particulate matter (PM) pollution has been demonstrated as an independent risk factor for pulmonary and cardiovascular diseases, their currently-available toxicological data is still far from sufficient to explain the ...
Xiaoting Jin +8 more
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Highly efficient platelet generation in lung vasculature reproduced by microfluidics
Nature Communications, 2023 Platelets, small hemostatic blood cells, are derived from megakaryocytes. Both bone marrow and lung are principal sites of thrombopoiesis although underlying mechanisms remain unclear.
Xiaojuan Zhao +20 more
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Nature Communications, 2020 Mutations affecting sialylation and galactosylation affect megakaryocyte function and thrombopoiesis. Here the authors show that the enzyme β4GalT1 regulates thrombopoiesis and hematopoietic stem cell homeostasis by controlling beta-1 integrin function.
Silvia Giannini +8 more
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Journal of Hematology & Oncology, 2023 Hyperhomocysteinemia (HHcy) is closely associated with thrombotic diseases such as myocardial infarction and stroke. Enhanced platelet activation was observed in animals and humans with HHcy.
Wenjing Lei +14 more
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Cells, 2021 Careful morphological investigations, coupled with experimental hematology studies in animal models and in in vitro human cultures, have identified that platelets are released in the circulation by mature megakaryocytes generated by hematopoietic stem ...
Anna Rita Migliaccio
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The ABC of Thrombopoiesis [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2014 Platelets play an important role in atherogenesis and atherothrombosis. At early stages of atherosclerosis, platelet-borne chemokines and platelet–leukocyte complexes contribute to the recruitment of neutrophils and monocytes to inflamed arteries.1,2 At late stages, platelets orchestrate additional processes such as thrombosis by direct mechanisms and ...
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