Results 11 to 20 of about 4,399 (180)
Mechanisms of thrombopoiesis [PDF]
Journal of Thrombosis and Haemostasis, 2005 Megakaryocytes (MKs) expand and differentiate over several days in response to thrombopoietin (Tpo) before releasing innumerable blood platelets. The final steps in platelet assembly and release represent a unique cellular transformation that is orchestrated by a range of transcription factors, signaling molecules, and cytoskeletal elements.
H, Schulze, R A, Shivdasani
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Studies on Thrombopoiesis [PDF]
Blood, 1957 Abstract Thrombocyte production from megakaryocytes of healthy humans, dogs, guinea pigs and mice was observed continuously for one to six days in tissue culture. Approximately 70 per cent of the explanted megakaryocytes broke down to give rise to numerous platelets, while the remaining 30 per cent of the cells remained ...
G. IZAK +3 more
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Journal of Hematology & Oncology, 2023 Hyperhomocysteinemia (HHcy) is closely associated with thrombotic diseases such as myocardial infarction and stroke. Enhanced platelet activation was observed in animals and humans with HHcy.
Wenjing Lei +14 more
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Cells, 2021 Careful morphological investigations, coupled with experimental hematology studies in animal models and in in vitro human cultures, have identified that platelets are released in the circulation by mature megakaryocytes generated by hematopoietic stem ...
Anna Rita Migliaccio
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The ABC of Thrombopoiesis [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2014 Platelets play an important role in atherogenesis and atherothrombosis. At early stages of atherosclerosis, platelet-borne chemokines and platelet–leukocyte complexes contribute to the recruitment of neutrophils and monocytes to inflamed arteries.1,2 At late stages, platelets orchestrate additional processes such as thrombosis by direct mechanisms and ...
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Kinetics of thrombopoiesis [PDF]
Journal of Clinical Investigation, 1968 Measurements of megakaryocyte number, volume, nuclear number, and cytoplasmic granulation were compared in animals with induced thrombocytosis, normal platelet counts, and induced thrombocytopenia for 4- and 10-day periods. Thrombopoiesis, as measured by megakaryocytic mass and (35)S incorporation into platelets, appeared to be regulated by the demand ...
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Molecular Therapy: Nucleic Acids, 2022 The use of messenger RNA (mRNA) enables the transient production of therapeutic proteins with stable and predictable translational kinetics and without the risk of insertional mutagenesis.
Yu Zhang +8 more
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Haematopoietic thrombocyte precursors in rat femoral and sternal bone marrow
Bulgarian Journal of Veterinary Medicine, 2021 This research presents the first findings on thrombopoiesis for Wistar rats. Haemopoietic cells from the femur and the sternum were analysed by light microscopy in combination with infrared and near-ultraviolet light for fine cytoplasmic structure ...
D. Suljević +4 more
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Frontiers in Pediatrics, 2021 Objective: Immature platelet counts (IPC) may prove useful in guiding platelet transfusion management in preterm neonates. However, the relationship between IPCs and thrombopoietin (Tpo) concentrations has not been evaluated in preterm neonates.Methods ...
Hannes Sallmon +7 more
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Effects of Sepsis on Neonatal Thrombopoiesis [PDF]
Pediatric Research, 2008 We serially evaluated the effects of sepsis and/or necrotizing enterocolitis (NEC) on neonatal thrombopoiesis, using a panel of tests that included platelet counts, thrombopoietin concentrations (Tpo), circulating megakaryocyte progenitor concentrations (CMPs), and reticulated platelets (RPs).
Rachel E, Brown +7 more
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