An open bone marrow megakaryocyte dataset for automated morphologic studies [PDF]
Scientific DataPrecise classification of megakaryocyte subtypes in bone marrow examination is crucial for the diagnosis and research of various hematological disorders, including Myelodysplastic Syndromes (MDS) and other platelet-production related diseases. While deep
Linghao Zhuang +5 more
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Megakaryocytes assemble a three-dimensional cage of extracellular matrix that controls their maturation and anchoring to the vascular niche [PDF]
eLifeMegakaryocytes, the progenitor cells of blood platelets, play a crucial role in hemostasis by residing in the bone marrow and ensuring continuous platelet production.
Claire Masson +17 more
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Megakaryocyte lineage development is controlled by modulation of protein acetylation. [PDF]
PLoS ONE, 2018 Treatment with lysine deacetylase inhibitors (KDACi) for haematological malignancies, is accompanied by haematological side effects including thrombocytopenia, suggesting that modulation of protein acetylation affects normal myeloid development, and ...
Marije Bartels +11 more
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High doses of romiplostim induce proliferation and reduce proplatelet formation by human megakaryocytes. [PDF]
PLoS ONE, 2013 Romiplostim (AMG531) is a Thrombopoietin (TPO) receptor agonist with no homology with the endogenous TPO that has been used to treat patients affected by immune thrombocytopenia (ITP).
Manuela Currao +2 more
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Effect of Mesenchymal Stem Cell-derived Microvesicles on Megakaryocytic Differentiation of CD34+ Hematopoietic Stem Cells [PDF]
Advanced Pharmaceutical Bulletin, 2020 Purpose: Mesenchymal stem cells (MSCs) release hematopoietic cytokines, growth factors, and Microvesicles (MVs) supporting the hematopoietic stem cells (HSCs).
Sara Aqmasheh +6 more
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Bio-Protocol, 2023 Primary hematopoietic stem and progenitor cell (HSPC)-derived megakaryocytes are a valuable tool for translational research interrogating disease pathogenesis and developing new therapeutic avenues for patients with hematologic disorders including ...
Chloe Thompson-Peach +3 more
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Scientific Reports, 2021 Megakaryocytes are a rare population of cells that develop in the bone marrow and function to produce platelets that circulate throughout the body and form clots to stop or prevent bleeding.
Lucas M. Bush +3 more
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In vitro megakaryocyte differentiation and proplatelet formation in Ph-negative classical myeloproliferative neoplasms: distinct patterns in the different clinical phenotypes. [PDF]
PLoS ONE, 2011 BackgroundPh-negative myeloproliferative neoplasms (MPNs) are clonal disorders that include primary myelofibrosis (PMF), polycythemia vera (PV) and essential thrombocythemia (ET).
Alessandra Balduini +7 more
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Asian Journal of Transfusion Science, 2022 INTRODUCTION: Thrombopoietin (TPO) being the major regulator of megakaryopoiesis is expected to show a compensatory increase in immune thrombocytopenia (ITP), however, it is not so observed.
Gurleen Oberoi +5 more
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Expansion of human megakaryocyte-biased hematopoietic stem cells by biomimetic Microniche
Nature Communications, 2023 Limited numbers of available hematopoietic stem cells (HSCs) limit the widespread use of HSC-based therapies. Expansion systems for functional heterogenous HSCs remain to be optimized.
Yinghui Li +26 more
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