Results 21 to 30 of about 24,025 (269)

Humanized mouse models for inherited thrombocytopenia studies

Platelets, 2023
Inherited thrombocytopenia (IT) is a group of hereditary disorders characterized by a reduced platelet count as the main clinical manifestation, and often with abnormal platelet function, which can subsequently lead to impaired hemostasis.
Xiaojie Wang, Maoshan Chen, Lanyue Hu, Chengning Tan, Xiaoliang Li, Peipei Xue, Yangzhou Jiang, Peipei Bao, Teng Yu, Fengjie Li, Yanni Xiao, Qian Ran, Zhongjun Li, Li Chen   +13 more
doaj   +1 more source

Itga2b regulation at the onset of definitive hematopoiesis and commitment to differentiation.

PLoS ONE, 2012
Product of the Itga2b gene, CD41 contributes to hematopoietic stem cell (HSC) and megakaryocyte/platelet functions. CD41 expression marks the onset of definitive hematopoiesis in the embryo where it participates in regulating the numbers of ...
Stephanie Dumon, David S Walton, Giacomo Volpe, Nicola Wilson, Emilie Dassé, Walter Del Pozzo, Josette-Renee Landry, Bryan Turner, Laura P O'Neill, Berthold Göttgens, Jon Frampton   +10 more
doaj   +1 more source

Relationship between Hepatitis B virus infection and platelet production and dysfunction

Platelets, 2022
Hepatitis B virus (HBV) is a kind of hepatotropic DNA virus. The main target organ is liver, except for liver, HBV has been found in a variety of extrahepatic tissues, such as kidney, thyroid, pancreas, bone marrow, etc.
Huinan Jiang, Yanwei Li, Qiuju Sheng, Xiaoguang Dou   +3 more
doaj   +1 more source

Megakaryocyte- and megakaryocyte precursor–related gene therapies [PDF]

Blood, 2016
AbstractHematopoietic stem cells (HSCs) can be safely collected from the body, genetically modified, and re-infused into a patient with the goal to express the transgene product for an individual’s lifetime. Hematologic defects that can be corrected with an allogeneic bone marrow transplant can theoretically also be treated with gene replacement ...
openaire   +2 more sources

Helios represses megakaryocyte priming in hematopoietic stem and progenitor cells

, 2021
Our understanding of cell fate decisions in hematopoietic stem cells is incomplete. Here, we show that the transcription factor Helios is highly expressed in murine hematopoietic stem and progenitor cells (HSPCs), where it is required to suppress the ...
Thibault-Carpentier, Christelle, Giovanni Cova, Marie-Céline Deau, Cerciat, Marie, Shevach, Ethan, Mittelheisser, Vincent,, Taroni, Chiara, Muriel Philipps, Chiara Taroni, Bernard Jost, Le Gras, Stéphanie, Leif Carlsson, Thornton, Angela M., Stéphanie Le Gras, Taroni, Chiara,, Susan Chan, Kirstetter, Peggy,, Kastner, Philippe,, Chan, Susan, Carlsson, Leif, Thibault-Carpentier, Christelle,, Philipps, Muriel, Christelle Thibault-Carpentier, Shevach, Ethan M.,, Philipps, Muriel,, Jost, Bernard,, Deau, Marie-Céline, Cerciat, Marie,, Qi Cai, Thornton, Angela M.,, Chan, Susan,, Matthieu Jung, Angela M. Thornton, Le Gras, Stéphanie,, Kastner, Philippe, Jost, Bernard, Shevach, Ethan M., Mittelheisser, Vincent, Vincent Mittelheisser, Deau, Marie-Céline,, Carlsson, Leif,, Kirstetter, Peggy, Marie Cerciat, Cai, Qi,, Ethan M. Shevach, Cova, Giovanni,, Jung, Matthieu,, Thornton, Angela, Cai, Qi, Philippe Kastner, Cova, Giovanni, Jung, Matthieu, Peggy Kirstetter   +52 more
core   +1 more source

The RNA-binding protein SRSF3 has an essential role in megakaryocyte maturation and platelet production

, 2022
RNA processing is increasingly recognized as a critical control point in the regulation of different hematopoietic lineages including megakaryocytes responsible for the production of platelets.
Josefsson, Emma C., Fulton, Madeline, Ahmad, Tanveer, Ramialison, Mirana, Änkö, Minna-Liisa, Cao, Huimin, Gangatirkar, Pradnya, Heazlewood, Chad K., Mohenska, Monika, Guo, Belinda B., Ellis, Sarah L., Nilsson, Susan K., Ratnadiwakara, Madara, Cao, Benjamin, Heazlewood, Shen Y., Williams, Brenda, White, Jacinta F.   +16 more
core   +3 more sources

Haematopoietic thrombocyte precursors in rat femoral and sternal bone marrow

Bulgarian Journal of Veterinary Medicine, 2021
This research presents the first findings on thrombopoiesis for Wistar rats. Haemopoietic cells from the femur and the sternum were analysed by light microscopy in combination with infrared and near-ultraviolet light for fine cytoplasmic structure ...
D. Suljević, A. Hamzić, E. Islamagić, E. Fejzić , A. Alijagić   +4 more
doaj   +1 more source

The GATA1s isoform is normally down-regulated during terminal haematopoietic differentiation and over-expression leads to failure to repress MYB, CCND2 and SKI during erythroid differentiation of K562 cells [PDF]

, 2012
Background: Although GATA1 is one of the most extensively studied haematopoietic transcription factors little is currently known about the physiological functions of its naturally occurring isoforms GATA1s and GATA1FL in humans—particularly whether the ...
Marie Docherty, Michelle Le Brocq, Brenda Gibson, Halsey, C., Derek Gilchrist, Docherty, M., Gilchrist, D., Gibson, B., McNeill, M., Christina Halsey, Halsey, Christina, Gerard Graham, Graham, G., Mhairi McNeill, Le Brocq, M.   +14 more
core   +1 more source

Blood and Bone: The quarantine chronicles

Research and Practice in Thrombosis and Haemostasis, 2020
In the midst of the chaos of the global pandemic, the online daily webinar series Blood and Bone was created. The series started with a blank schedule on a google doc and, with enthusiasm and participation from the hematopoiesis and hemostasis/thrombosis
Kirk A. Taylor, Kellie R. Machlus
doaj   +1 more source

Influences of various hormones on the megakaryocyte in bone-marrow tissue culture

, 1959
In our study on the influences of various hormones and various endocrines on the megakaryocyte function by means of bone-marrow tissue culture, we obtained the following. 1.
Hiraki, Kiyoshi, Sunami, Hiroshi, Nishishita, Hideo   +2 more
core   +1 more source