Results 31 to 40 of about 24,025 (269)

Single-cell profiling of human megakaryocyte-erythroid progenitors identifies distinct megakaryocyte and erythroid differentiation pathways [PDF]

, 2016
Background Recent advances in single-cell techniques have provided the opportunity to finely dissect cellular heterogeneity within populations previously defined by “bulk” assays and to uncover rare cell types.
Neil Ashley, Irene Roberts, Valentina S. Caputo, Lichtenberg, J, Ashley, Neil, David M. Bodine, Anderson, Stacie, Bethan Psaila, Barkas, N, Roy, A, Bodine, David M., Mead, AJ, Sandra Loaiza, Lichtenberg, Jens, Bodine, D, Anastasios Karadimitris, Iskander, D, Karadimitris, A, Iskander, Deena, Roy, Anindita, Caputo, Valentina S., Psaila, B, Nikolaos Barkas, Loaiza, Sandra, Anindita Roy, Mead, Adam J., Jens Lichtenberg, Roberts, Irene A.G., Adam J. Mead, Caputo, VS, Psaila, Bethan, Loaiza, S, Ashley, N, Bodine, DM, Anderson, S, Roberts, IAG, Deena Iskander, Barkas, Nikolaos, Karadimitris, Anastasios, Stacie Anderson, Roberts, I   +40 more
core   +2 more sources

Megakaryocyte Differentiation and Platelet Formation from Human Cord Blood-derived CD34+ Cells

, 2017
Platelet production occurs principally in the bone marrow in a process known as thrombopoiesis. During thrombopoiesis, hematopoietic progenitor cells differentiate to form platelet precursors called megakaryocytes, which terminally differentiate to ...
Beng H. Chong, Yan, F, Leung, HH ; https://orcid.org/, Feng Yan, Chong, BH ; https://orcid.org/, Halina H.L. Leung, Perdomo, JS ; https://orcid.org/, Jose Perdomo   +7 more
core   +1 more source

Human platelets and megakaryocytes express defensin alpha 1

Platelets, 2020
Platelets are anucleate cells that have a role in several innate immune functions, including the secretion of proteins with antimicrobial activity.
Xareni Valle-Jiménez, Adriana Ramírez-Cosmes, Alba Soledad Aquino-Domínguez, Francisco Sánchez-Peña, José Bustos-Arriaga, María De Los Ángeles Romero-Tlalolini, Honorio Torres-Aguilar, Jeanet Serafín-López, Sergio Roberto Aguilar Ruíz   +8 more
doaj   +1 more source

Immune Response in Severe and Non-Severe Coronavirus Disease 2019 (COVID-19) Infection: A Mechanistic Landscape

Frontiers in Immunology, 2021
The mechanisms underlying the immune remodeling and severity response in coronavirus disease 2019 (COVID-19) are yet to be fully elucidated. Our comprehensive integrative analyses of single-cell RNA sequencing (scRNAseq) data from four published studies,
Kavitha Mukund, Priya Nayak, Chethan Ashokkumar, Chethan Ashokkumar, Sohail Rao, Jose Almeda, Monica M. Betancourt-Garcia, Rakesh Sindhi, Rakesh Sindhi, Shankar Subramaniam, Shankar Subramaniam, Shankar Subramaniam   +11 more
doaj   +1 more source

Megakaryocyte - 1

, 2014
An image from a bone marrow showing a ...
Fraser, Marion
core   +1 more source

Megakaryocyte - 2

, 2010
An image from a bone marrow showing a large, multi-lobed, megakaryocyte surrounded by myeloid and erythroid ...
Fraser, Marion
core   +1 more source

Innate Immune Reprogramming Mediated by Endogenous Retroelement Dysregulation Drives Multiple Sclerosis Progression

Annals of Clinical and Translational Neurology, EarlyView.
Epigenetic reprogramming in hematopoietic stem and progenitor cells (HSPCs) and downstream myeloid cells, mediated by H3.3 downregulation and endogenous retroelement (ERE) overexpression, contributes to the progression of multiple sclerosis (MS). ABSTRACT Background Skewed myelopoiesis in the bone marrow has been identified as a key driver of multiple ...
Li‐Mei Xiao, Qiu‐Ping Zhao, Run‐Yun Li, Wei Chen, Huan‐Huan Song, Wan‐Jin Chen, Ying Fu   +6 more
wiley   +1 more source

In vitro Generation of Megakaryocytes and Platelets

Frontiers in Cell and Developmental Biology, 2021
Platelets, the tiny anucleate cells responsible for stopping bleeding through thrombosis, are derived from hematopoietic stem cells through a series of differentiation steps.
Huicong Liu, Jiaqing Liu, Lingna Wang, Fangfang Zhu   +3 more
doaj   +1 more source

Gut Microbiota Regulates Systemic Inflammatory Response and Compensatory Anti‐Inflammatory Response Syndromes by Targeting PF4+ Macrophages in Acute Pancreatitis

Advanced Science, EarlyView.
ABSTRACT Acute pancreatitis (AP) begins with pancreatic local inflammation, leading to the onset of systemic inflammatory response syndrome (SIRS), followed by compensatory anti‐inflammatory response syndrome (CARS), which causes immune paralysis and higher mortality rate.
Liwei Liu, Guanqun Li, Dongxu Lu, Haoran Ding, Tianqi Lu, Yuhang Sui, Can Zhang, Yu Xie, Rui Kong, Hua Chen, Xuewei Bai, Hongtao Tan, Dongbo Xue, Xianzhi Meng, Le Li, Bei Sun   +15 more
wiley   +1 more source

Synthesis of Cyclopropene‐Modified Fatty Acids Allows Single‐Cell Quantification of Uptake by Immune Cells

Angewandte Chemie, EarlyView.
Cyclopropene fatty acids have been made that allow the study of fatty acid uptake in complex mixtures of immune cells with single cell resolution and combined with metabolic and proteomic analysis so that for the first time nutrient uptake can be correlated to the phenotype of single immune cell.
Luuk Reinalda, Graham A. Heieis, Laura Bogue Edgerton, Kristine Bertheussen, Diana Torres‐García, Marouane el Boujadayni, Kas Steuten, Jeroen M. Punt, Wouter P. F. Driever, Connor Corrigan, Xinyuan Wang, Bart Everts, David Finlay, Mario van der Stelt, Sander I. van Kasteren   +14 more
wiley   +2 more sources