Results 51 to 60 of about 24,025 (269)
Prostacyclin prevents nitric oxide-induced megakaryocyte apoptosis [PDF]
, 2005 1. We have previously demonstrated that nitric oxide (NO) triggers CD34⁺-derived megakaryocyte apoptosis. We here show that prostacyclin (PGI₂) inhibits PAPA/NO-induced megakaryocyte death detected by fluorescent microscopy and flow cytometry. 2.
Negrotto, Soledad +6 more
core +2 more sources
Intravital imaging of megakaryocytes
Platelets, 2020 The dynamics of platelet formation could only be investigated since the development of two-photon microscopy in combination with suitable fluorescent labeling strategies. In this review paper, we give an overview of recent advances in fluorescence imaging of the bone marrow that have contributed to our understanding of platelet biogenesis during the ...
David Stegner, Katrin G. Heinze
openaire +3 more sources
Erythroid and megakaryocytic transformation [PDF]
Oncogene, 2007 Red blood cells and megakaryocytes arise from a common precursor, the megakaryocyte-erythroid progenitor and share many regulators including the transcription factors GATA-1 and GFI-1B and signaling molecules such as JAK2 and STAT5. These lineages also share the distinction of being associated with rare, but aggressive malignancies that have very poor ...
A, Wickrema, J D, Crispino
openaire +2 more sources
, 2014 Renal disease is the eighth leading cause of death in the United States. Early diagnosis is usually based on the detection of proteinuria or elevated serum creatinine, a relatively poor biomarker that does not accurately predict renal disease progression.
Elizabeth B. Somers +2 more
core +1 more source
Animal Models and Experimental Medicine, EarlyView.This graphical abstract illustrates the essential role of USB1 in neutrophil maturation. In normal myeloid cells, USB1 acts as an RNA exonuclease, trimming RNA tails to maintain proper RNA network function, which supports the differentiation of myeloid progenitor cells into mature neutrophils.
Hang Li +6 more
wiley +1 more source
Platelets, 2019 TMEM16F is a surface membrane protein critical for platelet procoagulant activity, which exhibits both phospholipid scramblase and ion channel activities following sustained elevation of cytosolic Ca2+.
Kirk A. Taylor, Martyn P. Mahaut-Smith
doaj +1 more source
Cold Spring Harbor Perspectives in Medicine, 2019 Acute megakaryoblastic leukemia (AMKL) is a rare malignancy affecting megakaryocytes, platelet-producing cells that reside in the bone marrow. Children with Down syndrome (DS) are particularly prone to developing the disease and have a different age of onset, distinct genetic mutations, and better prognosis as compared with individuals without DS who ...
Maureen, McNulty, John D, Crispino
openaire +3 more sources
Engraftment of sheep splenic lymphocytes into NBSGW mice and application in Brucella infection
Animal Models and Experimental Medicine, EarlyView.A sheep splenocyte‐reconstituted mouse model (Sh‐Spl mice) was established via intravenous injection of sheep splenic lymphocytes into immunodeficient mice to evaluate Brucella infection. Abstract Background The development of immune reconstituted xenograft mouse models has addressed the limitations imposed by interspecies immunological differences in ...
Xiaowei Wang +9 more
wiley +1 more source
Animal Models and Experimental Medicine, EarlyView.This study establishes an NPG (NOD.Cg‐Prkdcscid Il2rgtm1/Vst) mouse model for severe monkeypox virus infection in immunocompromised hosts, demonstrating dose‐dependent disease severity and revealing that unbalanced pro‐inflammatory cytokine release drives pathogenesis, providing insights for therapeutic interventions. Abstract The global spread of mpox
Na Li +11 more
wiley +1 more source
Sub-Cellular Localization of Metalloproteinases in Megakaryocytes
Cells, 2018 Metalloproteinases (MMPs) are zinc-dependent endopeptidases that play essential roles as the mediator of matrix degradation and remodeling during organogenesis, wound healing and angiogenesis.
Alessandro Malara +4 more
doaj +1 more source