Results 71 to 80 of about 21,749 (244)

Rho GTPases and their downstream effectors in megakaryocyte biology

Platelets, 2019
Megakaryocytes differentiate from hematopoietic stem cells in the bone marrow. The transition of megakaryocytes to platelets is a complex process. Thereby, megakaryocytes extend proplatelets into sinusoidal blood vessels, where the proplatelets undergo ...
Irina Pleines, Deya Cherpokova, Markus Bender   +2 more
doaj   +1 more source

Optimising Haematopoietic Stem Cell Transplantation: Enhancing Myeloablation Sensitivity and Alleviating Anaemia Using Roxadustat (FG‐4592)

Cell Proliferation, EarlyView.
The use of FG‐4592 in the process of myeloablation can promote haematopoietic cell apoptosis for more effective myeloablation, maintain the number of RBC and may create a pluripotent microenvironment suitable for donor cells, so as to enable more effective haematopoietic reconstruction of donor cells in vivo.
Guanheng Yang, Jiahui Wu, Xinbing Guo, Wenchen Shen, Xiao Sang, Xiuli Gong, Shu‐Zhen Huang, Jingzhi Zhang, Fanyi Zeng   +8 more
wiley   +1 more source

Comparative analysis of primary immune thrombocytopenia and immune thrombocytopenia secondary to connective tissue diseases

Hematology
Objectives To explore the differences between primary immune thrombocytopenia (ITP) and ITP secondary to connective tissue disease (CTD-ITP).Methods A retrospective observational study was conducted on patients newly diagnosed with primary ITP and CTD ...
Yingying Sun, Jinyue Yang, Lijuan Li, Jia Song, Xifeng Dong, Rong Fu, Huaquan Wang   +6 more
doaj   +1 more source

Ploidy‐Dependent Response to Anticancer Drugs of Human Embryonic Stem Cells

Cell Proliferation, EarlyView.
Using isogenic hESCs, differing only in their ploidy level, we show the effect of ploidy on the resistance to anticancer drugs. We demonstrate that polyploidy, by itself, confers sensitivity to chemotherapies, leading to higher apoptosis and delayed proliferation, while the loss of p53 reverses the phenotype, demonstrating higher resistance.
Guy Haim‐Abadi, Nissim Benvenisty
wiley   +1 more source

Megakaryocytes [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2020
Philip J. Crispin, Samantha J. Montague
openaire   +2 more sources

Thrombotic Microangiopathy‐Like Phenotype in Patients With Infection‐Associated Disseminated Intravascular Coagulation Treated With Thrombomodulin Alfa

European Journal of Haematology, EarlyView.
ABSTRACT Despite disseminated intravascular coagulation (DIC) and thrombotic microangiopathy (TMA) sharing features of thrombocytopenia, organ dysfunction, and bleeding, the relationship between these two conditions remains unclear. We therefore conducted a post hoc analysis of post‐marketing surveillance data from Japan to evaluate the clinical ...
Naoki Takezako, Fumiyo Komatsu, Goichi Honda, Noriaki Kawano, Toshimasa Uchiyama, Kazuo Kawasugi, Seiji Madoiwa, Kei Suzuki, Yoshinobu Seki, Takayuki Ikezoe, Kohji Okamoto, Hideo Wada   +11 more
wiley   +1 more source

Megakaryocytic Characteristics in Diagnosis of Patients with Thrombocytopenia

Pakistan Journal of Medicine and Dentistry
Background: The morphology of megakaryocytes plays a major role in thrombopoiesis. Dysmegakaryocytopoiesis and thrombocytopenia can result from imperfection in any phase of megakaryocytopoiesis.
Shahzad Ali Jiskani, Halar Rahim, Naila Noor, Rab Nawaz Sathio, Saba Ismaili Khawaja, Rizwan Ali Talpur   +5 more
doaj   +1 more source

Eosinophilia and Hypereosinophilia: A Practical Approach to Navigating a Broad Differential Diagnosis

European Journal of Haematology, EarlyView.
ABSTRACT Eosinophilia, defined as an absolute eosinophil count (AEC) of ≥ 0.5 × 109/L, is a frequently encountered finding with a vast spectrum of potential underlying etiologies. Hypereosinophilia (HE) is defined as AEC > 1.5 × 109/L and may become life‐threatening when eosinophil‐induced organ damage occurs, defining the hypereosinophilic syndrome ...
Stijn Wigerinck, Peter Vandenberghe
wiley   +1 more source

Endogenous spermidine biosynthesis contributes to fetal liver megakaryopoiesis and platelet production in mice

Platelets
Metabolic regulation is increasingly recognized as an important determinant of megakaryocyte development and platelet production, yet the metabolite-level characteristics of primary megakaryocytes from distinct developmental stages and tissue origins ...
Xing Liu, Meijuan Xia, Jiaojiao Guo, Liang Zhao, Yezi Ma, Long Li, Pei Su, Cuicui Liu, Fei Wang, Jiaxi Zhou, Wen Zhou, Hongtao Wang   +11 more
doaj   +1 more source

Bone Marrow Fibrosis as a Predictor of Extramedullary Disease in Multiple Myeloma

European Journal of Haematology, EarlyView.
ABSTRACT The correlation between bone marrow fibrosis (BMF) and extramedullary disease has yet to be fully elucidated in patients with newly diagnosed multiple myeloma. Therefore, we aimed to analyze the incidence of BMF in newly diagnosed multiple myeloma patients and evaluate the relationship between BMF and synchronous soft tissue extramedullary ...
Hilal Senkal, Ali Yilmaz Altay, Emine Goknur Isik, Simge Erdem, Metban Mastanzade, Gulcin Yegen, Mustafa Murat Ozbalak, İpek Yonal Hindilerden, Mustafa Nuri Yenerel, Sevgi Kalayoglu Besisik   +9 more
wiley   +1 more source