Results 81 to 90 of about 24,025 (269)

Safety Assessment and Hypoglycemic Effect of Moringa oleifera Lam. Seed Lectin (WSMoL) in Alloxan‐Induced Diabetic Mice

Journal of Applied Toxicology, EarlyView.
ABSTRACT Moringa oleifera Lam. seeds contain WSMoL, a lectin previously studied for toxicity and pharmacological effects. In this study, we investigated WSMoL (10, 25, or 50 mg/kg i.p.) for acute and 14‐day repeated‐dose toxicity, as well as genotoxicity, in Swiss mice.
Alícia Natalie Silva dos Santos, Matheus Cavalcanti de Barros, Cleidiane Silva Vieira de Souza, Ryan Cristian da Silva, Luana Cassandra Breitenbach Barroso Coelho, Maria Tereza dos Santos Correia, Fernanda das Chagas Ângelo Mendes Tenório, Alisson Macário de Oliveira, Thiago Henrique Napoleão, Robson Raion de Vasconcelos Alves, Patrícia Maria Guedes Paiva   +10 more
wiley   +1 more source

Immune signatures of megakaryocytes in persistent inflammation-immunosuppression and catabolism syndrome

Acta Biochimica et Biophysica Sinica
Persistent inflammation-immunosuppression and catabolism syndrome (PICS) is a severe condition that may follow sepsis and is characterized by ongoing inflammation and immune suppression, diminishing quality of life and potentially causing death. The role
Sun Xingfeng, Nan Ke, Zhong Ziwen, Liu Zhiqiang, Miao Changhong   +4 more
doaj   +1 more source

Rho GTPases and their downstream effectors in megakaryocyte biology

Platelets, 2019
Megakaryocytes differentiate from hematopoietic stem cells in the bone marrow. The transition of megakaryocytes to platelets is a complex process. Thereby, megakaryocytes extend proplatelets into sinusoidal blood vessels, where the proplatelets undergo ...
Irina Pleines, Deya Cherpokova, Markus Bender   +2 more
doaj   +1 more source

Pro-megakaryocyte

, 2007
Scheme electron microscopy. The pro-megakaryocyte (20-80 m) develops from a basophilic megakaryoblast (up to 50 m) that originates from a committed stem cell.
Poels, Lambert G.
core  

MPLW515L Increases the Number of Megakaryocyte and Myeloid Colonies in Spleen, without Affecting Megakaryocyte Ploidy, and Causes Cytokine-Independent Myeloid Colony Growth

, 2013
(A) Megakaryocyte colony–forming assay in the presence of TPO, IL3, IL11, and IL6 demonstrates similar numbers of megakaryocyte colonies obtained from MPLW515L-expressing bone marrow and an increase in the number of megakaryocyte colonies from spleen ...
Benjamin L Ebert (64260), Benjamin H Lee (64257), Jennifer J Clark (64267), Thomas Mercher (64258), Ross L Levine (64271), Gerlinde Wernig (64263), Daniel J DeAngelo (64266), Stephanie J Lee (64268), D. Gary Gilliland (64270), Ilene Galinsky (64265), Todd R Golub (48571), Yana Pikman (64256), Sandra Moore (64264), Martha Wadleigh (64269), Adam Cuker (64262), Elizabeth McDowell (64259), Maricel Gozo (64261)   +16 more
core   +1 more source

Reconceptualizing Aplastic Anemia—Seed, Worm, Soil

Journal of Clinical Laboratory Analysis, EarlyView.
Aplastic anemia (AA) encompasses a group of hematological syndromes often misdiagnosed, resulting in a decrease in the overall blood cell count and representing a form of bone marrow failure. We reinterpret AA based on the “seed, worm, and soil” doctrine.
Xintong Xu, Zining Wang, Jiaming Hu, Chunyan Liu, Rong Fu   +4 more
wiley   +1 more source

α-Actinin-1 in Megakaryocytes: Its Structure, Interacting Proteins and Implications for Thrombopoiesis

Biomedicines
Mutations in the ACTN1 gene, which encodes the cytoskeletal protein α-actinin-1, have been implicated in the etiology of autosomal dominant congenital macrothrombocytopenia.
Lanlan Wu, Zhiqun Song, Yulan Zhou, Jiansong Huang, Xiaoxia Huang   +4 more
doaj   +1 more source

Utility of a Combined Diagnostic and Severity Scoring System Based on Complete Blood Count and Derived Immune‐Inflammatory Indicators in Children With Mycoplasma pneumoniae Pneumonia

Journal of Clinical Laboratory Analysis, EarlyView.
This study developed a simple, low‐cost scoring system using routine complete blood count (CBC) and derived immune‐inflammatory indicators (LYM%, PLT, PCT, and PLT × LYM) for early diagnosis of Mycoplasma pneumoniae pneumonia (MPP) in 1662 children. Age‐stratified analysis confirmed that key indicators remained significantly higher in the pneumonia ...
Quan Liu, Li Wei, Liang Wang, Xing‐Mei Zhu, Hai‐Feng Wang, Ling Ge   +5 more
wiley   +1 more source

Piezo1 Mechanosensor Expression in Rare Hematopoietic Cells Controls Systemic Inflammatory Response in Mice

Cells
Mutations in the Piezo1 mechanosensor are associated with blood cell anomalies. The objective of our study was to explore the role of Piezo1 in the development and function of the megakaryocyte (MK) lineage.
Shiv Vardan Singh, Anastasia Iris Karkempetzaki, Nasi Huang, Vipul C. Chitalia, Saravanan Subramaniam, Katya Ravid   +5 more
doaj   +1 more source

Box-and-whisker plots of megakaryocyte output in suspension cultures.

, 2013
CD45+ (A) and CD34+ (B) cells from peripheral blood were sorted as described in Methods and cultured for 14 days. At the end of the cultures, the yield of megakaryocyte was calculated as output of CD41+ cells with megakaryocyte morphology.
Alessandra Balduini (287103), Annalisa De Silvestri (349861), Giovanni Barosi (325686), Denis Baev (131700), Vittorio Rosti (133339), Stefania Badalucco (349859), Marco Cattaneo (136461), Maria Teresa Pugliano (349860)   +7 more
core   +1 more source