Results 61 to 70 of about 24,025 (269)
Frontiers in Oncology, 2020 Numerous recurrent genetic mutations are known to occur in acute myeloid leukemia (AML). Among these common mutations, Fms-like tyrosine kinase 3 remains as one of the most frequently mutated genes in AML.
Kran Suknuntha +9 more
doaj +1 more source
Animal Models and Experimental Medicine, EarlyView.Substantial advances have been achieved in the development of humanized mouse models, which have proven highly valuable in evaluating cancer immunotherapies and elucidating the mechanisms of infectious diseases. There is now a growing shift in research toward larger animal models—such as pigs—that offer greater physiological similarity to humans ...
Yanan Lyu, Yong‐Guang Yang, Zheng Hu
wiley +1 more source
The role of the aryl hydrocarbon receptor in megakaryocyte development [PDF]
, 2016 Megakaryocyte specification is the process by which discrete hematopoietic subpopulations undergo lineage commitment towards the myeloid compartment, finally specifying as a megakaryocyte erythroid progenitor (MEP) by way of thrombopoietin (TPO) and ...
Smith, Brenden
core
RhoA deletion disrupts megakaryocyte development.
, 2013 (A) The differences in spleen weights were not statistically significant. (B) When adult RhoA-null platelets were infused into mαIIb−/−/hαIIb+/+ mice, the time course of platelet survival was similar to that of their controls.
Yangfeng Wang (436175) +11 more
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Cold Gas Plasma Induces Platelet Activation and Hemostasis in Native and Anticoagulated Human Blood
Advanced NanoBiomed Research, EarlyView.Cold physical gas plasma induces platelet activation and hemostatic responses in native and anticoagulated human blood. Treatment efficacy depends on plasma parameters, including gas composition, distance, and exposure mode, which govern reactive species delivery and energy transfer.
Sander Bekeschus +5 more
wiley +1 more source
Megakaryocytic Characteristics in Diagnosis of Patients with Thrombocytopenia
Pakistan Journal of Medicine and DentistryBackground: The morphology of megakaryocytes plays a major role in thrombopoiesis. Dysmegakaryocytopoiesis and thrombocytopenia can result from imperfection in any phase of megakaryocytopoiesis.
Shahzad Ali Jiskani +5 more
doaj +1 more source
The Journal of Pathology: Clinical Research, 2022 Myeloproliferative neoplasms (MPNs) are characterized by upregulation of proinflammatory cytokines and immune dysregulation, which provide a reasonable basis for immunotherapy in patients.
Sze‐Hwei Lee +10 more
doaj +1 more source
eLife, 2019 Bone marrow megakaryocytes engulf neutrophils in a phenomenon termed emperipolesis. We show here that emperipolesis is a dynamic process mediated actively by both lineages, in part through the β2-integrin/ICAM-1/ezrin pathway.
Pierre Cunin +13 more
doaj +1 more source
Harnessing blood clot as a native scaffold for orchestrating tissue repairs and regeneration
BMEMat, EarlyView.The blood clot, owing to its dynamic composition and unique microenvironment, holds significant yet underappreciated potential for tissue engineering. This review systematically summarizes the pathophysiology of clot formation, the key regulatory factors shaping its microenvironment, and its applications in both pre‐clinical and clinical settings ...
Gao‐peng Dang +13 more
wiley +1 more source
ESC Heart Failure, Volume 12, Issue 2, Page 1013-1028, April 2025.Abstract Heart failure with preserved ejection fraction (HFpEF) is characterized by a lack of a specific targeted treatment and a complex, partially unexplored pathophysiology. Common comorbidities associated with HFpEF are hypertension, atrial fibrillation, obesity and diabetes.
Giorgia D'Italia +2 more
wiley +1 more source