Results 101 to 110 of about 24,025 (269)
Detection of tissue factor in platelets: why is it so troublesome?
Platelets, 2019 Tissue factor (TF) is the most important trigger for the extrinsic coagulation pathway. TF, earlier denoted as thromboplastin, has always been a mystery since its discovery due to its abundant presence in most human tissues but not blood.
Bjarne Østerud, Beth A. Bouchard
doaj +1 more source
Proplatelet formation in OP9-derived megakaryocyte.
, 2013 A. Scanning electron micrograph of proplatelets (arrow indicated in yellow) forming OP9-derived CD41+ cells. B. Proplatelet-forming megakaryocyte was stained with antibody for CD41 (red) and alpha-tubulin (green), and DAPI (blue).
Mitsuru Murata (384696) +6 more
core +1 more source
British Journal of Haematology, EarlyView.Summary Immune thrombocytopenia (ITP) is a complex autoimmune disorder characterized by accelerated destruction of peripheral platelets and impaired megakaryopoiesis. While the cellular effectors, dysregulated T cells, hyperactive B cells and phagocytic macrophages are well characterized, the upstream epigenetic mechanisms orchestrating this ...
Zhenyu Liu +8 more
wiley +1 more source
British Journal of Haematology, EarlyView.Thrombocytosis is associated with an increased production of platelet‐derived microparticles from activated platelets, which contribute to vaso‐occlusion in sickle cell disease by perpetuating the cycle of inflammation, procoagulant state and endothelial dysfunction.
Giao N. Lê +3 more
wiley +1 more source
British Journal of Haematology, EarlyView.Summary Childhood autoimmune neutropenia (AIN) encompasses heterogeneous entities; phenotype‐specific immunological profiles and their relationship to infection outcomes remain incompletely defined. To characterise clinical, immunological and long‐term outcomes across distinct phenotypes of childhood AIN.
Ioanna Saougou +5 more
wiley +1 more source
Arteriosclerosis, Thrombosis, and Vascular Biology, 2020 Philip J. Crispin, Samantha J. Montague
openaire +2 more sources
Brain Pathology, EarlyView.Untargeted multiomic profiling of cerebrospinal fluid reveals that proteomic, but not lipidomic, signatures robustly distinguish ALS patients from controls and stratify individuals by survival, highlighting marked molecular differences between short survival and long survival disease.
Sergio Roca‐Pereira +19 more
wiley +1 more source
Haemostatic changes and bleeding with anti‐IL‐6 directed therapy in autoimmune diseases
British Journal of Pharmacology, EarlyView.Abstract Anti‐IL‐6 directed therapy, especially tocilizumab (TCZ), is widely used for the treatment of autoimmune diseases such as rheumatoid arthritis, giant cell arteritis and systemic juvenile idiopathic arthritis. Next to being a master regulator of inflammation, IL‐6 also is an important regulator of haemostasis. Although generally well tolerated,
Charlotte D. C. C. van der Heijden +3 more
wiley +1 more source
A circle of life: platelet and megakaryocyte cytoskeleton dynamics in health and disease
Open BiologyPlatelets are blood cells derived from megakaryocytes that play a central role in regulating haemostasis and vascular integrity. The microtubule cytoskeleton of megakaryocytes undergoes a critical dynamic reorganization during cycles of endomitosis and ...
Haonan Liu, Julie P. I. Welburn
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Cancer Science, EarlyView.An immune dysfunction score (IDS) provides independent prognostic information in MDS and CMML, complements current risk models, mirrors disease changes, and reflects underlying immune impairment. IDS may also highlight therapeutic sensitivities, supporting its use as a practical biomarker for risk stratification and clinical follow‐up.
Yu‐Hung Wang +16 more
wiley +1 more source