Results 121 to 130 of about 24,025 (269)
Seventh Åland Island Meeting on von Willebrand Disease
Haemophilia, EarlyView.ABSTRACT Introduction The seventh Åland Island Meeting on von Willebrand Disease (VWD) was held on the Åland archipelago in Finland, from 26 to 28 September 2024. Aim The meeting brought together experts in the field of VWD from around the world to share the latest advances and knowledge in VWD.
Riitta Lassila +17 more
wiley +1 more source
Molecular regulation of human megakaryocyte development.
, 1990 Extracellular regulators of human megakaryocyte development are becoming better defined. How these regulators function at the subcellular and, in particular, the molecular levels remains almost completely unknown.
CALABRETTA, Bruno, Gewirtz AM
core
Transcription factor networks in erythroid cell and megakaryocyte development
, 2011 Erythroid cells and megakaryocytes are derived from a common precursor, the megakaryocyte-erythroid progenitor. Although these 2 closely related hematopoietic cell types share many transcription factors, there are several key differences in their ...
John D. Crispino, Louis C. Doré
core +1 more source
Histopathology, EarlyView.New concepts, innovations and some issues have emerged since the adoption a decade ago of WHO/ISUP grading for CCRCC and PRCC. Continued use of the WHO/ISUP grading for CCRCC and PRCC has been upheld by newer studies, and practice guidance for some of the grading issues, where data are available, is provided.
Gladell P. Paner +4 more
wiley +1 more source
Apoptotic megakaryocyte dysplasia in the myelodysplastic syndromes
, 1992 The terminal phase of the megakaryocyte life span is characterized by the onset of apoptosis to form compact, denuded megakaryocyte nuclei (DMK) surrounded by a thin rim of cytoplasm.
Hatfill S.J., Steytler J.G., Fester E.D.
core
Danthron as a novel IL-6R agonist promotes thrombopoiesis via the SRC/RAS/MAPK pathway
Frontiers in ImmunologyBackgroundThis study aimed to investigate the effects of danthron on promoting megakaryocyte (MK) differentiation and alleviating thrombocytopenia, as well as to elucidate its underlying mechanisms.MethodsCell proliferation and apoptosis of Meg-01 and ...
Rui Liao +13 more
doaj +1 more source
The hematopoietic stem cells supportive megakaryocytes as shapers of the bone marrow niche
European Journal of HistochemistryThe bone marrow (BM) niche plays a pivotal role in regulating the fate of hematopoietic stem cells (HSCs), and its integrity changes significantly during aging and in rare hematological disease, as in myelofibrosis (MF).
Francesca Arciprete +8 more
doaj +1 more source
Small GTPases in megakaryocyte and platelet biology
, 2019 Review series that provides a state-of-the-art overview of the role of small GTPases in megakaryocyte and platelet biology. While the focus of the reviews is on recent advances in the area of basic science, the clinical relevance of alterations in small ...
Lucia Stefanini, Wolfgang Bergmeier
core +1 more source
International Journal of Laboratory Hematology, EarlyView.ABSTRACT Introduction Investigator‐led research and quality improvement initiatives have led to important improvements in the diagnostic assessment of platelet function disorders (PFD). Methods Personal reflections were used to summarize our contributions to knowledge on PFD diagnostic assessment, pathogenesis, and bleeding risks.
Catherine P. M. Hayward
wiley +1 more source
The importance of calcium in the regulation of megakaryocyte function
, 2014 Platelet release by megakaryocytes is regulated by a concert of environmental and autocrine factors. We previously showed that constitutively released adenosine diphosphate by human megakaryocytes leads to platelet production. Here we show that adenosine
Alessandra Balduini +7 more
core +1 more source