Results 121 to 130 of about 21,749 (244)

Immune and cellular determinants of response to HMA‐venetoclax regimens in acute myeloid leukemia

open access: yesHemaSphere, Volume 10, Issue 10, October 2026.
Abstract Hypomethylating agents (HMAs) combined with Venetoclax have reshaped the therapeutic landscape of acute myeloid leukemia (AML), yet the biological determinants of response remain unclear. We integrated clinical and genomic profiling in 132 newly diagnosed or relapsed/refractory AML patients treated with HMA‐Venetoclax and performed single‐cell
Alfredo Marchetti   +27 more
wiley   +1 more source

Identification of SORT1 as a Key Regulator of Antigen Presentation in CD16+ Monocytes During Septic Shock via Multi‐Omics and In Silico Gene Knockout Analysis

open access: yesImmunity, Inflammation and Disease, Volume 14, Issue 10, October 2026.
ABSTRACT Objective This study aimed to screen and identify hub genes correlated with septic shock through integrative analyses of bulk transcriptomics, machine learning, weighted gene co‐expression network analysis (WGCNA), single‐cell transcriptomics, and in silico gene knockout, and further dissect their underlying immunoregulatory mechanisms ...
Shulu Wu   +6 more
wiley   +1 more source

Plerixafor and G‐CSF Versus Placebo and G‐CSF in Moderately Mobilizing Patients With Multiple Myeloma to Optimize Hematopoietic Stem Cell Collection Results (OPTIMIZE)

open access: yesJournal of Clinical Apheresis, Volume 41, Issue 5, October 2026.
ABSTRACT Efficient collection of hematopoietic progenitor cells (HPCs) is essential for autologous stem cell transplantation (ASCT) in multiple myeloma (MM). Although plerixafor is routinely used in poor mobilizers, its role in patients with intermediate mobilization capacity remains unclear.
Worel Nina   +17 more
wiley   +1 more source

Development of a Machine Learning Algorithm for Differential Diagnosis Between Primary Immune Thrombocytopenia and Connective Tissue Disease‐Related Thrombocytopenia in Pediatric Patients

open access: yesJournal of Clinical Laboratory Analysis, Volume 40, Issue 19, October 2026.
Primary immune thrombocytopenia (ITP) and connective tissue disease‐related thrombocytopenia (CTD‐TP) share overlapping initial presentations in children, often leading to delayed diagnosis and suboptimal management. While existing literature focuses on therapeutic strategies, this study is the first to develop a machine learning (ML)‐based diagnostic ...
Furong Kang   +4 more
wiley   +1 more source

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