Results 111 to 120 of about 21,749 (244)

Molecular Dynamics‐Guided Sterol Engineering of mRNA‐Lipid Nanoparticles Reprograms Biodistribution and Enhances Spleen‐Selective Immunity

Advanced Science, Volume 13, Issue 57, 14 October 2026.
Sterol engineering enables precise control of mRNA lipid nanoparticles by tuning membrane organization. Replacing cholesterol with bile acid‐derived sterols redirects protein expression from the liver to the spleen. Notably, CA‐20 LNP enhances antigen‐specific immune responses while exhibiting a favorable safety profile, highlighting sterols as a ...
Sanghyuk Jeon, Seo‐Hyeon Bae, Jungyong Ji, Jisun Lee, Hosam Choi, Min‐Ho Kang, Sang‐In Park, Hyemin Kim, Nakyung Lee, Hajin Lee, Seonghoon Kim, Jungmin Kim, Subin Yoon, Seonghyun Lee, Seongje Cho, Dahyeon Ha, Ayoung Oh, Sohee Jo, Huijeong Choi, Yeeun Lee, Sowon Lee, Hyo‐Jung Park, Gitak Nam, Jisu Shin, Yujin Kang, Wonpil Im, Kiyoun Lee, Jae‐Hwan Nam   +27 more
wiley   +1 more source

megakaryocyte

Citation: 'megakaryocyte' in the IUPAC Compendium of Chemical Terminology, 5th ed.; International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.13449 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms. Requests for
openaire   +1 more source

POEMS Syndrome: 2026 Update on Diagnosis, Risk‐Stratification, and Management

American Journal of Hematology, Volume 101, Issue 10, Page 2632-2651, October 2026.
ABSTRACT Disease Overview POEMS syndrome is a life‐threatening syndrome due to an underlying plasma cell neoplasm. The major criteria for the syndrome are polyneuropathy, clonal plasma cell disorder (PCD), sclerotic bone lesions, elevated vascular endothelial growth factor, and the presence of Castleman disease.
Angela Dispenzieri
wiley   +1 more source

Rethinking Common Diagnoses: Idiopathic Multicentric Castleman Disease Presenting as TAFRO Syndrome: A Case Report

Clinical Case Reports, Volume 14, Issue 10, October 2026.
ABSTRACT Idiopathic multicentric Castleman disease (TAFRO subtype) can mimic common differentials. High suspicion is required for chronic systemic symptoms and generalized lymphadenopathy. As fine‐needle aspiration is often non‐diagnostic, early excisional biopsy is important.
Divita Rohatgi, Annesha Chakraborty, Sourav Kumar, Anurag Rohatgi   +3 more
wiley   +1 more source

Extensive Cerebral Venous Sinus Thrombosis With Obstructive Hydrocephalus in a Young Female With Underlying Essential Thrombocythemia: A Case Report

Clinical Case Reports, Volume 14, Issue 10, October 2026.
ABSTRACT Persistent symptoms suggestive of idiopathic intracranial hypertension despite standard therapy should prompt urgent neuroimaging to exclude cerebral venous sinus thrombosis. When CVST is confirmed without an obvious provoking factor, evaluation for underlying myeloproliferative neoplasms, including JAK2‐positive essential thrombocythemia, is ...
Sarah Nafea, Tasmia Farooq, Md Abu Taher, Andrea Barros, Kyaw Naing Soe, Fawad Ali, Koshy Thomas   +6 more
wiley   +1 more source

Myelodysplastic Syndromes‐Transformed Acute Myeloid Leukemia With Concurrent DEK::CAN Fusion Gene Positivity and WT1 Overexpression: A Case Report and Literature Review

Cancer Reports, Volume 9, Issue 10, October 2026.
ABSTRACT Background Myelodysplastic syndromes (MDS) are a group of clonal hematopoietic stem cell disorders with a risk of progression to acute myeloid leukemia (AML). MDS‐transformed AML (MDS‐AML) has a poor prognosis. The concurrent presence of DEK::CAN fusion gene positivity and WT1 overexpression is extremely rare and likely denotes a highly ...
Wanxiu Mao, Tengmin Zhou, Xi Xu, Sheng Luo, Songfu Jiang, Zhijie Yu   +5 more
wiley   +1 more source

Insights Into the Role of Platelet Factor 4 in Neurodegenerative Diseases

CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.
This review summarizes potential functions of platelet factor 4 (PF4) in neurodegenerative diseases (NDs) and discusses its promise as both a biomarker and a therapeutic target. Further elucidation of PF4 signaling pathways may provide new insights into disease mechanisms and uncover novel opportunities for targeted interventions in NDs.
Qi Tian, Yanji Tong, Fang Yu, Xiaoming Hu   +3 more
wiley   +1 more source

Isolation of Human Umbilical Cord Blood Hematopoietic Stem Cells and Directed Differentiation Into Megakaryocytes. [PDF]

Bio Protoc
Xia W, Miao Z, Zhang W, Liu Z, Wu H, Fan Y.   +5 more
europepmc   +1 more source

MAFG as a Redox‐Sensitive Node Linking Peripheral Immune Reprogramming to Cognitive Risk in the Sepsis‐to‐Alzheimer's Disease Continuum: Single‐Cell Dissection and Adoptive‐Transfer Validation

CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.
Sepsis reprograms circulating immune cells, raising the redox‐sensitive transcription factor MAFG in myeloid progenitors, dendritic cells, and platelets and suppressing their amyloid‐β scavenger receptors. Silencing MAFG restores amyloid‐β clearance, reduces cerebral plaques and microglial activation, and preserves cognition in APP/PS1 mice.
Xiaoyu Xiang, Tingting Li, Zhongxue Feng, Jing Yang, Zhiwen Gong, Lietao Wang, Lijun Wang, Wei Zhang   +7 more
wiley   +1 more source

Proteomics of heterogeneous megakaryocytes identifies JI051 as an enhancer of platelet biogenesis. [PDF]

Life Sci Alliance
Taga R, Kuwano N, Harada Y, Hayashi T, Sakamoto Y, Fujio K, Kakumoto Y, Nakamura E, Eto K, Hayashi H.   +9 more
europepmc   +1 more source