Results 111 to 120 of about 24,025 (269)

PACAP and its receptor VPAC1 regulate megakaryocyte maturation: therapeutic implications

, 2008
Megakaryocytes and platelets express the Gs-coupled VPAC1 receptor, for which the pituitary adenylyl cyclase-activating peptide (PACAP) and the vasointestinal peptide (VIP) are agonists.
De Vos, Rita, Hoylaerts, Marc, Vermylen, Jozef, Peeters, Karen, Thys, C., Freson, Kathleen, Wittevrongel, C., Van Geet, Christel   +7 more
core   +1 more source

A Rare Case of Cutaneous Extramedullary Hematopoiesis in Chronic Myeloid Leukemia

Journal of Cutaneous Pathology, EarlyView.
ABSTRACT Cutaneous extramedullary hematopoiesis (CEH) is a rare manifestation of extramedullary hematopoiesis (EMH), a process typically associated with fetal development or myeloproliferative neoplasms. EMH most commonly involves the spleen, liver, and lymph nodes, with CEH being exceedingly rare in chronic myeloid leukemia (CML).
Bennett Christie‐Nguyen, Hanadi El Achi, Levani Iashvili, Amer Wahed, Brenda Mai, Jacob Armstrong   +5 more
wiley   +1 more source

Phorbol esters: useful tools to study megakaryocyte differentiation.

, 1998
This review attempts 1) to enonciate recent observations made on the effects of phorbol esters on megakaryocyte cell lines, 2) to examine these effects taking into account megakaryocytopoiesis in vivo and 3) to demonstrate that phorbol esters stimulated ...
Baatout, SARAH
core  

Interstitial 11q Deletions and Terminal 11q Duplications Cause a Bleeding Tendency due to Platelet Dysfunction That Is Similar to 11q Deletions Causing Jacobsen Syndrome

European Journal of Haematology, EarlyView.
ABSTRACT Introduction Jacobsen syndrome, resulting from a terminal deletion of chromosome 11 (11q), may lead to an increased bleeding tendency due to low platelet counts or platelet dysfunction. Currently, information on bleeding tendency and platelet function in patients with nonterminal 11q‐aberrations such as larger deletions, interstitial 11q ...
Elise J. Huisman, Virgil A. S. H. Dalm, Marieke Joosten, Frans J. Smiers, Leendert Porcelijn, Arjan Hoogendijk, Hans Janssen, Nicole N. van der van der Wel, Idske C. L. Kremer Hovinga, Masja de Haas, Marjon H. Cnossen   +10 more
wiley   +1 more source

The Ontogeny of the megakaryocyte lineage

, 2012
Thesis (Ph. D.)--University of Rochester School of Medicine & Dentistry. Dept. of Biomedical Genetics, 2008.Megakaryocytes are the large cellular precursors to platelets, small blood cells that play an essential role in stabilizing and assisting in the ...
Palis, James, Tober, Joanna Michelle
core  

Mechanisms of Thrombocytosis in Iron‐Deficiency Anemia

European Journal of Haematology, EarlyView.
ABSTRACT Iron‐deficiency anemia is frequently accompanied by reactive thrombocytosis, yet the mechanisms underlying this association remain incompletely understood. Beyond impaired erythropoiesis, iron availability has emerged as an active regulator of hematopoietic lineage decisions.
João Vitor Facco, Diane S. Krause, Sara T. Olalla Saad   +2 more
wiley   +1 more source

Circulating megakaryocyte and platelet microvesicles correlate with response to ruxolitinib and distinct disease severity in patients with myelofibrosis

, 2019
The role of circulating microvesicles (MVs) in Myelofibrosis (MF) and Essential Thrombocythemia (ET) is far to be defined. Here we found that 1) circulating megakaryocyte-MVs were reduced in MF and ET while platelet-MVs were increased; 2) the proportion
Auteri G., Tazzari P. L., Barone M., Catani L., Forte D., Palandri F., Sollazzo D., Romano M., Bartoletti D., Cavo M., Reggiani M. L. B., Ricci F., Ottaviani E., Vianelli N.   +13 more
core   +1 more source

Biogenesis of TNF‐α‐insights into proteostasis and inflammation

The FEBS Journal, EarlyView.
TNF‐α biogenesis, trafficking, and signalling are tightly and reciprocally coupled to cellular proteostasis systems, including ER chaperones and endoplasmic reticulum‐associated degradation. This bidirectional crosstalk determines whether TNF‐α responses are adaptive or proteotoxic.
Bailasan Haidar, Céline Philippe, Eric Chevet, Jiří Zahradník   +3 more
wiley   +1 more source

Identification of unipotent megakaryocyte progenitors in human hematopoiesis

, 2018
The developmental pathway for human megakaryocytes remains unclear, and the definition of pure unipotent megakaryocyte progenitor is still controversial.
宮脇, 恒太, Miyawaki, Kohta, ミヤワキ, コウタ   +2 more
core  

Characterization of a megakaryocyte-specific enhancer of the key hemopoietic transcription factor GATA1

, 2005
Specification and differentiation of the megakaryocyte and erythroid lineages from a common bipotential progenitor provides a well studied model to dissect binary cell fate decisions.
Porcher, C, Vyas, Paresh, Dear, N., Vyas, P., Valverde-Garduno, V, Hammett, M, Dear, N, Guyot, B, Murai, K, Guyot, B., Valverde-Garduno, V., Hammett, M., Murai, K., S.H., Orkin, Fujiwara, Y, Wells, S, Orkin, SH, Vyas, P, Wells, S., Porcher, C., Fujiwara, Y.   +20 more
core   +1 more source