Results 11 to 20 of about 24,025 (269)

Megakaryocyte apoptosis in immune thrombocytopenia

Platelets, 2018
The mechanisms of platelet underproduction in immune thrombocytopenia (ITP) remain unknown. While the number of megakaryocytes is normal or increased in ITP bone marrow, further studies of megakaryocyte integrity are needed.
John R. Vrbensky, Ishac Nazy, Lisa J. Toltl, Catherine Ross, Nikola Ivetic, James W. Smith, John G. Kelton, Donald M. Arnold   +7 more
doaj   +2 more sources

Megakaryocyte [PDF]

Einstein (São Paulo), 2011
Paulo Augusto Achucarro Silveira, Elvira Deolinda Rodrigues Pereira Velloso, Marjorie Paris Colombini, João Carlos de Campos Guerra, Nydia Strachman Bacal, Alanna Mara Pinheiro Sobreira Bezerra, Denise da Cunha Pasqualin   +6 more
doaj   +10 more sources

Megakaryocyte-erythroid lineage promiscuity in EKLF null mouse blood [PDF]

Haematologica, 2010
Commitment towards megakaryocyte versus erythroid blood cell lineages occurs in the megakaryocyte-erythroid progenitor, where mutually exclusive expression of either EKLF (Klf1) or Fli1 defines alternative outcomes.
Michael R. Tallack, Andrew C. Perkins
doaj   +2 more sources

DNMT3A regulates murine megakaryocyte-biased hematopoietic stem cell fate decisions

Blood Advances
: Hematopoietic stem cells (HSCs) are defined by their capacity to regenerate all main components of peripheral blood, but individual HSCs exhibit a range of preferences for generating downstream cell types.
Sarah M. Waldvogel, Virginia Camacho, Dandan Fan, Anna G. Guzman, Alejandra Garcia-Martell, Elmira Khabusheva, Jacey Rodriguez Pridgen, Josephine De La Fuente, Rachel Rau, Ashlyn G. Laidman, Maria N. Barrachina, Estelle Carminita, Justin A. Courson, Michael R. Williamson, Joanne I. Hsu, Chun-Wei Chen, Jaime Reyes, Subhashree Pradhan, Rolando E. Rumbaut, Alan R. Burns, Benjamin Deneen, Jianzhong Su, Kellie R. Machlus, Margaret A. Goodell   +23 more
doaj   +2 more sources

Megakaryocyte emperipolesis: a new frontier in cell-in-cell interaction

Platelets, 2020
Histology of bone marrow routinely identifies megakaryocytes that enclose neutrophils and other hematopoietic cells, a phenomenon termed emperipolesis.
Pierre Cunin, Peter A. Nigrovic
doaj   +2 more sources

MicroRNA function in megakaryocytes

Platelets, 2019
Megakaryocytes (MKs), the largest cells in the bone marrow, are generated from hematopoietic stem cells (HSCs) in a sequential process called megakaryocytopoiesis in which HSCs undergo MK-progenitor (MP) commitment and maturation to terminally ...
Sanjeev Raghuwanshi, Swati Dahariya, Syed Shahid Musvi, Usha Gutti, Ravinder Kandi, Ram Babu Undi, Itishri Sahu, Dushyant Kumar Gautam, Indira Paddibhatla, Ravi Kumar Gutti   +9 more
doaj   +3 more sources

The determination of megakaryocyte ploidy

The International Journal of Cell Cloning, 1990
Methods which have been used to determine megakaryocyte ploidy in animals and humans are reviewed. Although the number of megakaryocyte nuclear units counted in bone marrow squashes is roughly proportional to ploidy, accurate determinations of DNA content require the use of microphotometry or flow cytometry.
J M, Paulus, J M, Senterre, R, von Frenckell   +2 more
openaire   +3 more sources

CD34+ megakaryocytes and megakaryocytic fragments in myelodysplastic syndrome [PDF]

Blood, 2017
![Figure][1] A 65-year-old woman presented with fatigue and exertional dyspnea. The peripheral blood showed: hemoglobin, 91 g/L; leukocytes, 4.8 × 109/L with 1% blast cells; and platelets, 35 × 109/L with megakaryocytic fragments (panel A, filled black arrow; original magnification ×100;
Yan, Chen, Hong, Chang
openaire   +2 more sources

Lineage tracing of Pf4-Cre marks hematopoietic stem cells and their progeny [PDF]

, 2012
The development of a megakaryocyte lineage specific Cre deleter, using the Pf4 (CXCL4) promoter (Pf4-Cre), was a significant step forward in the specific analysis of platelet and megakaryocyte cell biology.
Calaminus, Simon, Watson, Steve P., Tessa L. Holyoake, Guitart, Amelie V., Amelie V Guitart, Calaminus, Simon D J, Machesky, Laura, Schachtner, Hannah, Steve P Watson, Amelie V. Guitart, Amy Sinclair, Amelie Guitart, Kranc, Kamil R., Machesky, Laura M, Holyoake, Tessa L., Holyoake, Tessa L, Calaminus, Simon D.J., Steve P. Watson, Watson, Steve P, Guitart, Amelie, Machesky, Laura M., Simon D J Calaminus, Kranc, Kamil R, Watson, Steve, Laura M. Machesky, Holyoake, Tessa, Sinclair, Amy, Hannah Schachtner, Simon D. J. Calaminus, Laura M Machesky, Guitart, Amelie, V, Tessa L Holyoake, Kranc, Kamil, Kamil R. Kranc, Kamil R Kranc   +34 more
core   +1 more source

Stepwise GATA1 and SMC3 mutations alter megakaryocyte differentiation in a Down syndrome leukemia model

The Journal of Clinical Investigation, 2023
Acute megakaryoblastic leukemia of Down syndrome (DS-AMKL) is a model of clonal evolution from a preleukemic transient myeloproliferative disorder requiring both a trisomy 21 (T21) and a GATA1s mutation to a leukemia driven by additional driver mutations.
Brahim Arkoun, Elie Robert, Fabien Boudia, Stefania Mazzi, Virginie Dufour, Aurélie Siret, Yasmine Mammasse, Zakia Aid, Matthieu Vieira, Aygun Imanci, Marine Aglave, Marie Cambot, Rachel Petermann, Sylvie Souquere, Philippe Rameau, Cyril Catelain, Romain Diot, Gérard Tachdjian, Olivier Hermine, Nathalie Droin, Najet Debili, Isabelle Plo, Sébastien Malinge, Eric Soler, Hana Raslova, Thomas Mercher, William Vainchenker   +26 more
doaj   +1 more source