Results 11 to 20 of about 21,749 (244)
MicroRNA function in megakaryocytes
Platelets, 2019 Megakaryocytes (MKs), the largest cells in the bone marrow, are generated from hematopoietic stem cells (HSCs) in a sequential process called megakaryocytopoiesis in which HSCs undergo MK-progenitor (MP) commitment and maturation to terminally ...
Sanjeev Raghuwanshi +9 more
doaj +3 more sources
CD34+ megakaryocytes and megakaryocytic fragments in myelodysplastic syndrome [PDF]
Blood, 2017 ![Figure][1] A 65-year-old woman presented with fatigue and exertional dyspnea. The peripheral blood showed: hemoglobin, 91 g/L; leukocytes, 4.8 × 109/L with 1% blast cells; and platelets, 35 × 109/L with megakaryocytic fragments (panel A, filled black arrow; original magnification ×100;
Yan, Chen, Hong, Chang
openaire +2 more sources
Megakaryocyte-erythroid lineage promiscuity in EKLF null mouse blood
Haematologica, 2010 Commitment towards megakaryocyte versus erythroid blood cell lineages occurs in the megakaryocyte-erythroid progenitor, where mutually exclusive expression of either EKLF (Klf1) or Fli1 defines alternative outcomes.
Michael R. Tallack, Andrew C. Perkins
doaj +1 more source
Megakaryocyte apoptosis in immune thrombocytopenia
Platelets, 2018 The mechanisms of platelet underproduction in immune thrombocytopenia (ITP) remain unknown. While the number of megakaryocytes is normal or increased in ITP bone marrow, further studies of megakaryocyte integrity are needed.
John R. Vrbensky +7 more
doaj +1 more source
The Journal of Clinical Investigation, 2023 Acute megakaryoblastic leukemia of Down syndrome (DS-AMKL) is a model of clonal evolution from a preleukemic transient myeloproliferative disorder requiring both a trisomy 21 (T21) and a GATA1s mutation to a leukemia driven by additional driver mutations.
Brahim Arkoun +26 more
doaj +1 more source
Humanized mouse models for inherited thrombocytopenia studies
Platelets, 2023 Inherited thrombocytopenia (IT) is a group of hereditary disorders characterized by a reduced platelet count as the main clinical manifestation, and often with abnormal platelet function, which can subsequently lead to impaired hemostasis.
Xiaojie Wang +13 more
doaj +1 more source
Itga2b regulation at the onset of definitive hematopoiesis and commitment to differentiation.
PLoS ONE, 2012 Product of the Itga2b gene, CD41 contributes to hematopoietic stem cell (HSC) and megakaryocyte/platelet functions. CD41 expression marks the onset of definitive hematopoiesis in the embryo where it participates in regulating the numbers of ...
Stephanie Dumon +10 more
doaj +1 more source
Relationship between Hepatitis B virus infection and platelet production and dysfunction
Platelets, 2022 Hepatitis B virus (HBV) is a kind of hepatotropic DNA virus. The main target organ is liver, except for liver, HBV has been found in a variety of extrahepatic tissues, such as kidney, thyroid, pancreas, bone marrow, etc.
Huinan Jiang +3 more
doaj +1 more source
Megakaryocyte- and megakaryocyte precursor–related gene therapies [PDF]
Blood, 2016 AbstractHematopoietic stem cells (HSCs) can be safely collected from the body, genetically modified, and re-infused into a patient with the goal to express the transgene product for an individual’s lifetime. Hematologic defects that can be corrected with an allogeneic bone marrow transplant can theoretically also be treated with gene replacement ...
openaire +2 more sources