Results 41 to 50 of about 4,399 (180)

Antibacterial and Immunomodulatory Activities of a Natural Polysaccharide Against Staphylococcus aureus Infection

Food Science &Nutrition, Volume 14, Issue 10, October 2026.
Polysaccharides from Polygonatum kingianum (PKP) were extracted with ethanol and hot distilled water, followed by centrifugation and drying. In vitro, PKP inhibited both E. coli and Staphylococcus aureus in a concentration‐dependent manner, with stronger activity against the Gram‐positive S. aureus (89.8% at 400 mg/mL) than against E.
Xu‐Chen Xia, Ya‐Qi Peng, Lu‐Xuan Liu, Bing Cao, Xue‐Kun Zhong, Xi‐Dong Wu, Tao Liu   +6 more
wiley   +1 more source

Quantitative systems pharmacology model of thrombopoiesis and platelet life‐cycle, and its application to thrombocytopenia based on chronic liver disease

CPT: Pharmacometrics & Systems Pharmacology, 2021
Platelets are produced by hematopoietic stem cells via megakaryocytes in the bone marrow and play a critical role in hemostasis. The aim of this study was to develop a new platelet model based on the thrombopoiesis and platelet life‐cycle by a ...
Ryosuke Shimizu, Takayuki Katsube, Toshihiro Wajima   +2 more
doaj   +1 more source

Oxymatrine, a novel TLR2 agonist, promotes megakaryopoiesis and thrombopoiesis through the STING/NF-κB pathway

Journal of Pharmaceutical Analysis
Radiation-induced thrombocytopenia (RIT) faces a perplexing challenge in the clinical treatment of cancer patients, and current therapeutic approaches are inadequate in the clinical settings.
Chengyang Ni, Ling Zhou, Shuo Yang, Mei Ran, Jiesi Luo, Kui Cheng, Feihong Huang, Xiaoqin Tang, Xiang Xie, Dalian Qin, Qibing Mei, Long Wang, Juan Xiao, Jianming Wu   +13 more
doaj   +1 more source

Vaccination Accelerates Liver-Intrinsic Expression of Megakaryocyte-Related Genes in Response to Blood-Stage Malaria

Vaccines, 2022
Erythropoiesis and megakaryo-/thrombopoiesis occur in the bone marrow proceeding from common, even bipotent, progenitor cells. Recently, we have shown that protective vaccination accelerates extramedullary hepatic erythroblastosis in response to blood ...
Frank Wunderlich, Denis Delic, Daniela Gerovska, Marcos J. Araúzo-Bravo   +3 more
doaj   +1 more source

Diagnostic Performance of Complete Blood Count Derived Indices for Acute Coronary Syndrome in Emergency Department Patients With Acute Chest Pain: A Single‐Center Retrospective Diagnostic Accuracy Study

Health Science Reports, Volume 9, Issue 10, October 2026.
ABSTRACT Background and Aims Acute coronary syndrome (ACS), as one of the cardiovascular diseases, plays a significant role in patient mortality. Although appropriate diagnostic methods have been introduced for ACS, it still remains a challenge for physicians. Therefore, utilizing additional markers and ratios for the diagnosis of ACS can be beneficial.
Mohammad Ghorbani, Mostafa Shakeri, Elahe Rahimi, Ebrahim Salavati, Raheleh Derafshi, Mohamad Esmail Gheydari, Amirhossein Gholizadeh Behabadi   +6 more
wiley   +1 more source

Plasma Exchange for Hantavirus Pulmonary Syndrome: A Mechanistic Case for an Untested Intervention

Journal of Clinical Apheresis, Volume 41, Issue 5, October 2026.
ABSTRACT Hantavirus pulmonary syndrome (HPS) carries a case fatality rate of 35%–40% and has no approved pharmacologic treatment. Its pathophysiology is rooted in the plasma compartment: cytokines, viral antigens, immune complexes, and platelet‐binding glycoproteins circulate as drivers of immunopathologic endothelial injury, noncardiogenic pulmonary ...
Menatalla Nadim, Yasamin Mirzabeigi, Yamac Akgun   +2 more
wiley   +1 more source

Excessive serine from the bone marrow microenvironment impairs megakaryopoiesis and thrombopoiesis in Multiple Myeloma

Nature Communications, 2023
Thrombocytopenia is a major complication in a subset of patients with multiple myeloma (MM). However, little is known about its development and significance during MM. Here, we show thrombocytopenia is linked to poor prognosis in MM.
Chunmei Kuang, Meijuan Xia, Gang An, CuiCui Liu, Cong Hu, Jingyu Zhang, Zhenhao Liu, Bin Meng, Pei Su, Jiliang Xia, Jiaojiao Guo, Yinghong Zhu, Xing Liu, Xuan Wu, Yi Shen, Xiangling Feng, Yanjuan He, Jian Li, Lugui Qiu, Jiaxi Zhou, Wen Zhou   +20 more
doaj   +1 more source

From haemostasis to immunity: The expanding frontiers of platelet biology

British Journal of Haematology, Volume 209, Issue 4, Page 1482-1485, October 2026.
Platelets are versatile cells whose functions extend far beyond haemostasis and thrombosis, actively regulating innate and adaptive immunity, angiogenesis, lymphangiogenesis, liver regeneration, atherosclerosis and tumour metastasis. This demonstrates their central role in various physiological processes and multiple life‐threatening diseases ...
Xun Grace Wu, Nicole Tomei, Heyu Ni
wiley   +1 more source

A megakaryocyte in the peripheral blood: evidence for pulmonary migration?

Frontiers in Hematology
Pulmonary megakaryocytes were first identified over a century ago, but their origin is still debated. Two rare images of circulating megakaryocytes are presented to illustrate this discussion: The first shows an intact megakaryocyte with abundant ...
Stephanie Juané Kennedy, Stephanie Juané Kennedy   +1 more
doaj   +1 more source

Thrombopoietin-independent generation of platelet-like particles from megakaryoblastic cells

Scientific Reports, 2023
The use of megakaryoblastic leukemia MEG-01 cells can help reveal the mechanisms of thrombopoiesis. However, conventional in vitro activation of platelet release from MEG-01 cells requires thrombopoietin, which is costly.
Nuntiporn Nunthanasup, Nutpakal Ketprasit, Egarit Noulsri, Attakorn Palasuwan, Valery Combes, Kasem Kulkeaw, Duangdao Palasuwan   +6 more
doaj   +1 more source