Results 61 to 70 of about 4,192 (175)

Physiologic Role of TPO in Thrombopoiesis [PDF]

Stem Cells, 1996
Recombinant human thrombopoietin (rHuTPO) serves as a megakaryocyte colony-stimulating factor and predominantly acts on GPIIb/IIIa+ rat late megakaryocyte progenitor cells, colony forming units-megakaryocyte (CFU-MK). The GPIIb/IIIa+ fraction of CFU-MK differentiates into mature megakaryocytes and further into proplatelets in liquid culture containing ...
openaire   +2 more sources

Phenotypic profiling of pristane‐induced mimicking human systemic lupus erythematosus in Macaca fascicularis

Animal Models and Experimental Medicine, Volume 9, Issue 7, Page 1302-1309, July 2026.
Pristane (5 mL/kg) induced a robust systemic lupus erythematosus (SLE)‐like phenotype in Macaca fascicularis, marked by elevated antinuclear antibody (ANA) levels and systemic clinical, hematological, and biochemical changes. This model closely reflects human SLE and provides a translational platform for disease studies and therapeutic evaluation ...
Jonny Jonny, Soetojo Wirjopranoto, Chairul A. Nidom, I Ketut Sudiana, Terawan A. Putranto, Elisa D. Pratiwi, Tiza W. Mawaddah, Astria N. Nidom, Reviany V. Nidom, Setyarina Indrasari, Irma Y. Rosytania, Hiqmah Y. Yana, Sanindita Kusumastuti   +12 more
wiley   +1 more source

A novel method for automated assessment of megakaryocyte differentiation and proplatelet formation

Platelets, 2018
Transfusion of platelet concentrates represents an important treatment for various bleeding complications. However, the short half-life and frequent contaminations with bacteria restrict the availability of platelet concentrates and raise a clear demand ...
M. Salzmann, B. Hoesel, M. Haase, M. Mussbacher, WC. Schrottmaier, JB. Kral-Pointner, M. Finsterbusch, A. Mazharian, A. Assinger, JA. Schmid   +9 more
doaj   +1 more source

MicroRNAs as potential architects of immune dysregulation and megakaryocytic failure in immune thrombocytopenia

British Journal of Haematology, Volume 209, Issue 1, Page 16-27, July 2026.
Summary Immune thrombocytopenia (ITP) is a complex autoimmune disorder characterized by accelerated destruction of peripheral platelets and impaired megakaryopoiesis. While the cellular effectors, dysregulated T cells, hyperactive B cells and phagocytic macrophages are well characterized, the upstream epigenetic mechanisms orchestrating this ...
Zhenyu Liu, Johan Rebetz, Lamya Garabet, Waleed Ghanima, Peipei Xu, Hans Wadenvik, Drew Provan, Rick Kapur, John W. Semple   +8 more
wiley   +1 more source

Interleukins in Platelet Biology: Unraveling the Complex Regulatory Network

Pharmaceuticals
Interleukins, a diverse family of cytokines produced by various cells, play crucial roles in immune responses, immunoregulation, and a wide range of physiological and pathological processes.
Miao Huang, Long Wang, Qianhui Zhang, Ling Zhou, Rui Liao, Anguo Wu, Xinle Wang, Jiesi Luo, Feihong Huang, Wenjun Zou, Jianming Wu   +10 more
doaj   +1 more source

Integrating Oncolytic Virus Engineering and Delivery Strategies for Enhanced Cancer Virotherapy

Aggregate, Volume 7, Issue 6, June 2026.
Integrated engineering strategies combining oncolytic virus (OV) design with advanced delivery platforms overcome biological barriers and enhance cancer virotherapy. Genetic engineering improves viral potency and selectivity, while local and systemic delivery systems promote viral protection, tumor targeting, penetration, and tumor microenvironment ...
Jiliang Zhao, Dong Wang, Lei Wang, Hongkai Zhang, Yue Sun, Dan Ding   +5 more
wiley   +1 more source

What Is Your Diagnosis? Abnormal WNR Scattergram From the Sysmex XN‐1000V in a Dog

Veterinary Clinical Pathology, EarlyView.
Javier Martínez‐Caro, Marta Lemos, Albert Lloret, Josep Pastor   +3 more
wiley   +1 more source

Sub-Cellular Localization of Metalloproteinases in Megakaryocytes

Cells, 2018
Metalloproteinases (MMPs) are zinc-dependent endopeptidases that play essential roles as the mediator of matrix degradation and remodeling during organogenesis, wound healing and angiogenesis.
Alessandro Malara, Daniela Ligi, Christian A. Di Buduo, Ferdinando Mannello, Alessandra Balduini   +4 more
doaj   +1 more source

Historical review: megakaryopoiesis and thrombopoiesis [PDF]

Blood, 2008
Abstract The study of thrombopoiesis has evolved greatly since an era when platelets were termed “the dust of the blood,” only about 100 years ago. During this time megakaryocytes were identified as the origin of blood platelets; marrow-derived megakaryocytic progenitor cells were functionally defined and then purified; and the primary ...
openaire   +2 more sources

Reticulated Platelets and an Optimal Model for Differentiating Thrombocytopenia Etiologies

eJHaem, Volume 7, Issue 3, June 2026.
ABSTRACT Objectives This study aimed to investigate the clinical value of reticulated platelets (RtcPLT) percentage derived from an automated hematology analyzer in differentiating thrombocytopenia due to peripheral etiology from decreased bone marrow production (BME). In addition, a secondary objective was to establish specific reference intervals for
Tung Thanh Tran, Quyen Ngoc Truong, Hong Phuoc Mac, Thang Thanh Phan, Tai Chau Quach, Son Truong Nguyen   +5 more
wiley   +1 more source