Results 61 to 70 of about 4,399 (180)
Pediatric Investigation, Volume 10, Issue 4, Page 359-373, August 2026.This evidence map of 63 studies (n = 6158) showed growth hormone therapy in children with growth hormone deficiency has neutral glucose effects, mixed lipid outcomes, potential benefits for bone mineral density, bone mineral content, and parathyroid hormone, but generally no impact on thyroid function, body composition, or body mass index.
Wei Wu +6 more
wiley +1 more source
What Is Your Diagnosis? Abnormal WNR Scattergram From the Sysmex XN‐1000V in a Dog
Veterinary Clinical Pathology, EarlyView.
Javier Martínez‐Caro +3 more
wiley +1 more source
British Journal of Haematology, Volume 209, Issue 2, Page 420-431, August 2026.Thrombocytosis is associated with an increased production of platelet‐derived microparticles from activated platelets, which contribute to vaso‐occlusion in sickle cell disease by perpetuating the cycle of inflammation, procoagulant state and endothelial dysfunction.
Giao N. Lê +3 more
wiley +1 more source
Haemostatic changes and bleeding with anti‐IL‐6 directed therapy in autoimmune diseases
British Journal of Pharmacology, Volume 183, Issue 15, Page 4111-4125, August 2026.Abstract Anti‐IL‐6 directed therapy, especially tocilizumab (TCZ), is widely used for the treatment of autoimmune diseases such as rheumatoid arthritis, giant cell arteritis and systemic juvenile idiopathic arthritis. Next to being a master regulator of inflammation, IL‐6 also is an important regulator of haemostasis. Although generally well tolerated,
Charlotte D. C. C. van der Heijden +3 more
wiley +1 more source
Sub-Cellular Localization of Metalloproteinases in Megakaryocytes
Cells, 2018 Metalloproteinases (MMPs) are zinc-dependent endopeptidases that play essential roles as the mediator of matrix degradation and remodeling during organogenesis, wound healing and angiogenesis.
Alessandro Malara +4 more
doaj +1 more source
A MATHEMATICAL MODEL OF THROMBOPOIESIS IN RATS
Cell Proliferation, 1979 ABSTRACTA mathematical model of thrombopoiesis in rats is presented. This has four compartments; stem cells, megakaryocytes, thrombocytes and thrombopoietin. A high thrombopoietin concentration influences bone marrow proliferation in three ways. Firstly the stem cells are stimulated and a slow increase in megakaryocyte number follows.
H E, Wichmann +3 more
openaire +2 more sources
The thrombopoietin receptor S264F mutant drives MPN with marrow fibrosis through a dual mechanism
HemaSphere, Volume 10, Issue 10, October 2026.
Charlotte Lees +9 more
wiley +1 more source
International Journal of Cancer, Volume 159, Issue 2, Page 302-319, 15 July 2026.Abstract Tumor‐educated platelets (TEPs) are emerging as a compelling frontier in liquid biopsy, functioning as dynamic, systemic sensors that sequester and process tumor‐derived biomolecules. This interaction imprints an integrated molecular signature of malignancy—spanning the transcriptome, proteome, lipidome, and crucially, the captured genome ...
Whi‐An Kwon +5 more
wiley +1 more source
Historical review: megakaryopoiesis and thrombopoiesis [PDF]
Blood, 2008 Abstract The study of thrombopoiesis has evolved greatly since an era when platelets were termed “the dust of the blood,” only about 100 years ago. During this time megakaryocytes were identified as the origin of blood platelets; marrow-derived megakaryocytic progenitor cells were functionally defined and then purified; and the primary ...
openaire +2 more sources
ChemBioChem, Volume 27, Issue 13, 14 July 2026.The function of bromodomain‐containing proteins in regulating gene transcription is reviewed here, including the development of chemical probes and targeted protein degradation modalities (e.g., PROTACs). This extends to clinical efforts targeting the BET bromodomain‐containing proteins. Challenges of selectivity, future prospects, and the differential
Cole R. Scholtz, William C. K. Pomerantz
wiley +1 more source