Results 71 to 80 of about 4,399 (180)

Regulating mitochondrial oxidative phosphorylation and MAPK signaling: wedelolactone as a novel therapeutic for radiation-induced thrombocytopenia

Frontiers in Pharmacology
IntroductionRadiation-induced thrombocytopenia (RIT) is a serious complication of cancer radiotherapy, for which therapeutic options are limited. This study investigates wedelolactone (WED), a metabolite of a botanical drug, as a potential treatment for ...
Zhichao Li, Qinyao Li, Shuang Wu, Xinyue Mei, Xiao Qi, Sheng Liu, Gan Qiao, Hongping Shen, Jiesi Luo, Jing Zeng, Feihong Huang, Rong Li, Rong Li, Long Wang   +13 more
doaj   +1 more source

Phenotypic profiling of pristane‐induced mimicking human systemic lupus erythematosus in Macaca fascicularis

Animal Models and Experimental Medicine, Volume 9, Issue 7, Page 1302-1309, July 2026.
Pristane (5 mL/kg) induced a robust systemic lupus erythematosus (SLE)‐like phenotype in Macaca fascicularis, marked by elevated antinuclear antibody (ANA) levels and systemic clinical, hematological, and biochemical changes. This model closely reflects human SLE and provides a translational platform for disease studies and therapeutic evaluation ...
Jonny Jonny, Soetojo Wirjopranoto, Chairul A. Nidom, I Ketut Sudiana, Terawan A. Putranto, Elisa D. Pratiwi, Tiza W. Mawaddah, Astria N. Nidom, Reviany V. Nidom, Setyarina Indrasari, Irma Y. Rosytania, Hiqmah Y. Yana, Sanindita Kusumastuti   +12 more
wiley   +1 more source

Rapamycin and bafilomycin A1 alter autophagy and megakaryopoiesis

Platelets, 2017
Autophagy is an effective strategy for cell development by recycling cytoplasmic constituents. Genetic deletion of autophagy mediator Atg7 in hematopoietic stem cells (HSCs) can lead to failure of megakaryopoiesis and enhanced autophagy has been ...
Qi Wang, Tao You, Hongqiong Fan, Yinyan Wang, Tinatian Chu, Mortimer Poncz, Li Zhu   +6 more
doaj   +1 more source

Utility of immature platelet fraction in the Sysmex XN‐1000V for the differential diagnosis of central and peripheral thrombocytopenia in dogs and cats

Journal of Veterinary Internal Medicine
Background The immature platelet fraction (IPF), a parameter obtained by the Sysmex XN‐1000V analyzer, is used in humans to differentiate between central (CEN) and peripheral (PER) thrombocytopenia (TP) but has not been evaluated in small animals ...
Alejandro Perez‐Ecija, Carmen Martinez, Julio Fernandez‐Castañer, Francisco J. Mendoza   +3 more
doaj   +1 more source

Endogenous spermidine biosynthesis contributes to fetal liver megakaryopoiesis and platelet production in mice

Platelets
Metabolic regulation is increasingly recognized as an important determinant of megakaryocyte development and platelet production, yet the metabolite-level characteristics of primary megakaryocytes from distinct developmental stages and tissue origins ...
Xing Liu, Meijuan Xia, Jiaojiao Guo, Liang Zhao, Yezi Ma, Long Li, Pei Su, Cuicui Liu, Fei Wang, Jiaxi Zhou, Wen Zhou, Hongtao Wang   +11 more
doaj   +1 more source

Autoantibody-mediated desialylation impairs human thrombopoiesis and platelet lifespan

Haematologica, 2019
Immune thrombocytopenia is a common bleeding disease caused by autoantibody-mediated accelerated platelet clearance and impaired thrombopoiesis. Accumulating evidence suggests that desialylation affects platelet life span in immune thrombocytopenia ...
Irene Marini, Jan Zlamal, Christoph Faul, Ursula Holzer, Stefanie Hammer, Lisann Pelzl, Wolfgang Bethge, Karina Althaus, Tamam Bakchoul   +8 more
doaj   +1 more source

Defects in TRPM7 channel function deregulate thrombopoiesis through altered cellular Mg2+ homeostasis and cytoskeletal architecture

Nature Communications, 2016
Although Mg2+is vital for platelet activation and aggregation, its regulation in these cells is still largely unknown. Here, the authors show that TRPM7, a cation channel and a protein kinase, regulates thrombopoiesis and platelet size by affecting the ...
Simon Stritt, Paquita Nurden, Remi Favier, Marie Favier, Silvia Ferioli, Sanjeev K. Gotru, Judith M M. van Eeuwijk, Harald Schulze, Alan T. Nurden, Michele P. Lambert, Ernest Turro, Stephanie Burger-Stritt, Masayuki Matsushita, Lorenz Mittermeier, Paola Ballerini, Susanna Zierler, Michael A. Laffan, Vladimir Chubanov, Thomas Gudermann, Bernhard Nieswandt, Attila Braun   +20 more
doaj   +1 more source

Modeling individual time courses of thrombopoiesis during multi-cyclic chemotherapy.

PLoS Computational Biology, 2019
BACKGROUND:Thrombocytopenia is a major side-effect of cytotoxic cancer therapies. The aim of precision medicine is to develop therapy modifications accounting for the individual's risk.
Yuri Kheifetz, Markus Scholz
doaj   +1 more source

Human thrombopoiesis depends on Protein kinase Cδ/protein kinase Cε functional couple

Haematologica, 2016
A deeper understanding of the molecular events driving megakaryocytopoiesis and thrombopoiesis is essential to regulate in vitro and in vivo platelet production for clinical applications.
Cecilia Carubbi, Elena Masselli, Silvia Martini, Daniela Galli, Franco Aversa, Prisco Mirandola, Joseph E. Italiano, Giuliana Gobbi, Marco Vitale   +8 more
doaj   +1 more source

Salicylate Inhibits Thrombopoiesis in Rat Megakaryocytes by Changing the Membrane Micro-Architecture

Cellular Physiology and Biochemistry, 2015
Background/Aims: Salicylate causes drug-induced immune thrombocytopenia. However, some clinical studies indicate the presence of additional mechanisms in the drug-induced thrombocytopenia, by which the platelet production from megakaryocytes may directly
Itsuro Kazama, Asuka Baba, Yasuhiro Endo, Hiroaki Toyama, Yutaka Ejima, Mitsunobu Matsubara, Masahiro Tachi   +6 more
doaj   +1 more source