Results 51 to 60 of about 4,399 (180)

Physiologic Role of TPO in Thrombopoiesis [PDF]

Stem Cells, 1996
Recombinant human thrombopoietin (rHuTPO) serves as a megakaryocyte colony-stimulating factor and predominantly acts on GPIIb/IIIa+ rat late megakaryocyte progenitor cells, colony forming units-megakaryocyte (CFU-MK). The GPIIb/IIIa+ fraction of CFU-MK differentiates into mature megakaryocytes and further into proplatelets in liquid culture containing ...
openaire   +2 more sources

Overall Survival Benefit and Long‐Term Safety of Romiplostim in Persistent Chemotherapy‐Induced Thrombocytopenia

American Journal of Hematology, EarlyView.
Andrew B. Song, Gerald A. Soff
wiley   +1 more source

The lung is more than an organ of gas exchange: immunocompetency, platelets and implications for drug discovery

British Journal of Pharmacology, Volume 183, Issue 20, Page 5999-6006, October 2026.
Abstract The lungs have for a long time been recognised as having pharmacological significance as a specific organ to modulate the pharmacokinetics of endogenous substances needed to maintain homeostasis. The lungs are therefore the site of action of certain drugs that act on these homeostatic processes, resulting in systemic effects on the ...
Simon C. Pitchford
wiley   +1 more source

Effect of simvastatin on thrombopoiesis in porcine bone marrow

Journal of Veterinary Research, 2019
Introduction: Statins are pharmacological agents commonly used to lower serum cholesterol level. The aim of the experiment was to investigate the effect of the statin simvastatin on thrombopoiesis in the porcine model because it is the closest to the ...
Snarska Anna, Wysocka Dominika, Rytel Liliana   +2 more
doaj   +1 more source

Calreticulin in Essential Thrombocythemia: StressINg OUT the Megakaryocyte Nucleus

Frontiers in Oncology, 2017
Calreticulin (CALR) is a multifaceted protein primarily involved in intracellular protein control processes. The identification of CALR mutations in essential thrombocythemia (ET) and primary myelofibrosis that are mutually exclusive with the JAK2 V617F ...
Francisco Jose Iborra, Petros Papadopoulos   +1 more
doaj   +1 more source

Tropomyosin 1 Promotes Platelet Adhesion and Clot Contraction Separate from Its Roles in Developmental Hematopoiesis

Advanced Science, Volume 13, Issue 48, 28 August 2026.
ABSTRACT Genome‐wide association studies (GWAS) link the Tropomyosin 1 (Tpm1) locus to quantitative blood trait variation, but related mechanisms are unclear. Tpm1 encodes an actin‐binding protein that regulates actin filament diversity, cell adhesion, signaling, and actomyosin contractility.
Po‐Lun Kung, Victor Tsao, Alina D Peshkova, Oscar A. Marcos‐Contreras, Kim Ha, Brian M Dulmovits, Nkemdilim Okoli, Anvi Sinha, Gennadiy Fonar, Rong Qiu, Rolf D Bates, Janelle Yeboah, Carson Shalaby, Tyler Truex, Soomin Jeong, Edna C Hardeman, Peter W Gunning, Vladimir R Muzykantov, Jacob W Myerson, Christopher S Thom   +19 more
wiley   +1 more source

Thrombocytopenia in dengue infection: mechanisms and a potential application

Expert Reviews in Molecular Medicine
Thrombocytopenia is a common symptom and one of the warning signs of dengue virus (DENV) infection. Platelet depletion is critical as it may lead to other severe dengue symptoms.
Ahmad Suhail Khazali, Waqiyuddin Hilmi Hadrawi, Fatimah Ibrahim, Shatrah Othman, Nurshamimi Nor Rashid   +4 more
doaj   +1 more source

A novel method for automated assessment of megakaryocyte differentiation and proplatelet formation

Platelets, 2018
Transfusion of platelet concentrates represents an important treatment for various bleeding complications. However, the short half-life and frequent contaminations with bacteria restrict the availability of platelet concentrates and raise a clear demand ...
M. Salzmann, B. Hoesel, M. Haase, M. Mussbacher, WC. Schrottmaier, JB. Kral-Pointner, M. Finsterbusch, A. Mazharian, A. Assinger, JA. Schmid   +9 more
doaj   +1 more source

Dose‐Dependent Anti‐Obesity and Protective Effects of Chia (Salvia hispanica L.) Seed Oil Against Hematological and Hepatorenal Dysfunction in High‐Fat Diet–Fed Mice

Food Science &Nutrition, Volume 14, Issue 8, August 2026.
Chia seed oil ameliorates obesity, dyslipidemia, and hepatorenal dysfunction in high‐fat diet–fed mice. ABSTRACT Chia seeds (Salvia hispanica L.) are recognized as a functional food with a nutrient‐dense profile and health‐promoting properties. In the present study, hexane‐extracted chia seed oil was investigated for anti‐obesity, hematoprotective, and
Sabbya Sachi, Mst. Prianka Jahan, Sree Alok Kumar, Mahmudul Hasan Sikder, Md. Zahorul Islam   +4 more
wiley   +1 more source

Interleukins in Platelet Biology: Unraveling the Complex Regulatory Network

Pharmaceuticals
Interleukins, a diverse family of cytokines produced by various cells, play crucial roles in immune responses, immunoregulation, and a wide range of physiological and pathological processes.
Miao Huang, Long Wang, Qianhui Zhang, Ling Zhou, Rui Liao, Anguo Wu, Xinle Wang, Jiesi Luo, Feihong Huang, Wenjun Zou, Jianming Wu   +10 more
doaj   +1 more source