Results 181 to 190 of about 7,460 (217)

Thrombopoiesis‐stimulating agents and myelodysplastic syndromes

British Journal of Haematology, 2015
SummaryThrombocytopenia in patients with myelodysplastic syndromes (MDS) is a frequent cause of haemorrhage‐related morbidity and mortality, and is associated with increased risk of leukaemic transformation and reduced overall survival. In addition, thrombocytopenia in MDS limits the tolerability and therapeutic efficacy of disease‐modifying therapies,
Charlotte K, Brierley, David P, Steensma
openaire   +2 more sources

Effect of ethanol on thrombopoiesis

British Journal of Haematology, 1986
Summary. Chronic ethanol abuse causes thrombocytopenia but the underlying mechanism is unknown. To determine the target cells involved, we examined the effects of the drug in vitro on both megakaryocyte progenitor cells (CFU‐Meg) and isolated, maturing megakaryocytes.
R F, Levine, J L, Spivak, R C, Meagher, F, Sieber   +3 more
openaire   +2 more sources

Thrombopoiesis: new ITP paradigm?

Blood, 2011
Immune thrombocytopenia (ITP) is usually acute and self-limited in children, although bleeding symptoms are occasionally severe and do not respond to conventional therapy. In this issue of Blood , Bussel and colleagues report initial phase 1/2 safety and efficacy data using romiplostim, a ...
Jenny M, Despotovic, Russell E, Ware
openaire   +2 more sources

Megakaryocytes and Thrombopoiesis

Journal of thrombosis and haemostasis, 2009
http://onlinelibrary.wiley.com/doi/10.1111/jth.2009.7.issue-s2 ...
Hartwig, John H, Begonja, Antonija, Falet, Herve, Patel-Hett, Sunita, Thon, Jonathan, Italiano, Joeseph   +5 more
openaire   +2 more sources

Asialo platelets enhance thrombopoiesis.

Transactions of the Association of American Physicians, 1981
Because the terminal sialic acid of several glycoproteins regulates their intravascular half-life, and because asialo platelets have a shortened survival, we postulated that asialo platelets might affect the basal rate of thrombopoiesis. Thrombopoiesis was measured by the incorporation of intravenous 75Se-selenomethionine (a cohort label) into ...
S, Karpatkin, S, Shulman
openaire   +2 more sources

Megakaryopoiesis and Thrombopoiesis

2017
Platelets are formed from the cytoplasm of megakaryocytes (MKs) that reside in the bone marrow (BM). MKs arise from hematopoietic stem cells in the osteoblastic niche in BM. The primary regulator of megakaryopoiesis is thrombopoietin. It is generally accepted that MKs migrate into the vascular niche and produce platelets; however, the mechanism by ...
Shugo Kowata, Yoji Ishida
openaire   +1 more source

Transcriptional Regulation of Thrombopoiesis.

Blood, 2008
Abstract Over the past two decades, a number of key transcription factors have been identified that play essential roles in megakaryocyte development. These include GATA-1, GATA-2, Friend of GATA-1 (FOG-1), Runx-1, Cbf-β, Fli-1, GABPα, TEL, NF-E2 p45, Gfi-1b, and SCL/TAL.
Alan B. Cantor, Hui Huang, Andrew Woo, James Mann, Ming Yu, Thomas Akie, Nathan Tu, Barry H. Paw   +7 more
openaire   +1 more source

3D Model of Thrombopoiesis.

Blood, 2010
Abstract Abstract 1609 Background. The mechanisms that regulate megakaryocytic (Mk) development within the bone marrow environment remain poorly understood. The underlying relationships between Mk maturation and bone marrow components are key factors in this process.
Isabella Pallotta, Michael L. Lovett, David L. Kaplan, Alessandra Balduini   +3 more
openaire   +1 more source

Molecular Control of Megakaryopoiesis and Thrombopoiesis

International Journal of Hematology, 2002
Megakaryopoiesis and subsequent thrombopoiesis occur through complex biologic steps: megakaryocyte precursors that developed from hematopoietic stem cells initially proliferate, then differentiate into mature polyploid megakaryocytes, and finally release platelets.
Itaru, Matsumura, Yuzuru, Kanakura
openaire   +2 more sources

Thrombopoietin: a tool for understanding thrombopoiesis

Journal of Thrombosis and Haemostasis, 2003
Although first proposed to be the primary regulator of platelet production 45 years ago, the gene for thrombopoietin was cloned only within the last decade. Since then, our understanding of megakaryocyte and platelet production has increased substantially, and it is now appreciated that in addition to its critical role in regulating thrombopoiesis, the
openaire   +2 more sources