Results 101 to 110 of about 1,702,455 (203)

Genetic studies of hereditary thrombocythemia [PDF]

, 2013
Hereditary thrombocythemia (HT) is a familial myeloproliferative disorder characterized by an elevated platelet count in peripheral blood. Thrombocytosis is due to a genetic alteration that can be transmitted to the offspring.
Pianta, Annalisa
core   +1 more source

Use of Thrombopoietin Receptor Agonists in Severe Aplastic Anemia During Pregnancy: A Case Report

Immuno
Severe aplastic anemia (SAA) in pregnancy represents a rare but life-threatening clinical challenge. Standard therapies such as hematopoietic stem cell transplantation (HSCT) and immunosuppressive therapy are limited during pregnancy due to safety ...
Mostafa F. Mohammed Saleh, Ahemd Kotb Abrabou, Abdulrahman Nasiri, Alfadil Haroon, Mahmoud Aljurf   +4 more
doaj   +1 more source

Dopamine receptor subtypes and ingestive behaviour [PDF]

, 1999
Both centrally and systemically administered dopamine agonists and antagonists decrease ingestive behaviour. The aim of this thesis was to examine whether drugs acting at different receptor subtypes decreased intake in different ways.
Genn, Rachel F., Genn, R.F.
core  

An agonist antibody prefers relapsed AML for induction of cells that kill each other [PDF]

, 2019
Previously, we reported an agonist antibody to a cytokine receptor, Thrombopoietin receptor (TPOR) that effectively induces cytotoxic killer cells from precursor tumor cells isolated from newly diagnosed AML patients.
Arlian, Britni M., Jones, Teresa M., Jung, Dokyung, Zhang, Hongkai, Shin, Sanghee, Oh, Yong-Seok, Han, Kyung Ho, Zha, Zhao, Kim, Minseok S., Lerner, Richard A., Yea, Kyungmoo   +10 more
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Role of romiplostim in splenectomized and nonsplenectomized patients with immune thrombocytopenia

ImmunoTargets and Therapy, 2016
Jose Perdomo Hematology Research Unit, St George and Sutherland Clinical School, University of New South Wales, Kogarah, NSW, Australia Abstract: Romiplostim is a thrombopoietin receptor agonist (TPO-RA) used for the treatment of adult primary immune ...
Perdomo J
doaj  

Data mining and safety analysis of avatrombopag: a retrospective pharmacovigilance study based on the US food and drug administration’s adverse event reporting system

Scientific Reports
With its increasing use in the treatment of thrombocytopenia, avatrombopag’s associated adverse events (AEs) pose a major challenge to its clinical application. This study aims to comprehensively study AEs associated with avatrombopag by using real-world
Hong Zhu, Meng Wu
doaj   +1 more source

The Use of Thrombopoietin Receptor Agonists for Correction of Thrombocytopenia prior to Elective Procedures in Chronic Liver Diseases: Review of Current Evidence

International Journal of Hepatology, 2016
Patients with chronic liver diseases (CLD) undergo a range of invasive procedures during their clinical lifetime. Various hemostatic abnormalities are frequently identified during the periprocedural work-up; including thrombocytopenia.
Kamran Qureshi, Shyam Patel, Andrew Meillier   +2 more
doaj   +1 more source

Paraneoplastic thrombocytosis in ovarian cancer [PDF]

, 2012
<p>Background: The mechanisms of paraneoplastic thrombocytosis in ovarian cancer and the role that platelets play in abetting cancer growth are unclear.</p> <p>Methods: We analyzed clinical data on 619 patients with epithelial ...
Han, H.D., Wang, R., Collins, K., Drew, A.F., Vasquez, H.G., Coward, J., Deavers, M.T., Urbauer, D., Lamkin, D., Matsuo, K., Sood, A.K., Stone, R.L., Lopez-Berestein, G., Bottsford-Miller, J., Shahzad, M.M.K., King, E.R., Mcneish, I.A., Afshar-Kharghan, V., Gershenson, H., Rupairmoole, R., Ahn, E.H., DeGeest, K., Gushiken, F., Tekedereli, I., Ozpolat, B., Nick, A.M., Chiu, W., Armaiz-Pena, G.N., Lutgendorf, S.K., Landen, C.N., Bond, V.K., Balkwill, F., Hu, W., Pecot, C.V.   +33 more
core   +1 more source

Openings of the rat recombinant alpha1 homomeric glycine receptor as a function of the number of sgonist molecules bound [PDF]

, 2002
The functional properties of rat homomeric {alpha}1 glycine receptors were investigated using whole-cell and outside-out recording from human embryonic kidney cells transfected with rat {alpha}1 subunit cDNA.
Beato, M., Colquhoun, D., Groot-Kormelink, P.J., Sivilotti, L.G.   +3 more
core  

An Uncommon Association: Eltrombopag and Autoimmune Hepatitis

Case Reports in Hepatology
Autoimmune hepatitis (AIH) is an immunological disorder of the liver characterized by hepatic necroinflammation due to the break in self-tolerance to autoantigens. Many medications have been linked to drug induced AIH.
Fady Salama, Hassnain Syed, Nimish Thakral   +2 more
doaj   +1 more source