Results 111 to 120 of about 1,702,455 (203)

Orientation-specific signalling by thrombopoietin receptor dimers.

, 2011
Ligand binding to the thrombopoietin receptor is thought to stabilize an active receptor dimer that regulates megakaryocyte differentiation and platelet formation, as well as haematopoietic stem cell renewal.
Smith, Steven O, Emilie Leroy, Jean-Philippe Defour, Judith Staerk, William Vainchenker, Pecquet, Christian, Brett, Ian, Defour, Jean-Philippe, Leroy, Emilie, Miki Itaya, Vainchenker, William, Steven O Smith, Staerk, Judith, Stefan N Constantinescu, Constantinescu, Stefan N., Christian Pecquet, Hélène Antoine-Poirel, Poirel, Hélène, Ian Brett, Itaya, Miki   +19 more
core   +1 more source

Eltrombopag use in surgical procedures in inherited thrombocytopenia: expanding the role of thrombopoietin-receptor agonists

Research and Practice in Thrombosis and Haemostasis
Background: Inherited thrombocytopenias (ITs) are a group of rare disorders characterized by low platelet counts and variable bleeding risk. Surgical procedures in these patients often require transient platelet elevation.
Miguel de Oliveira, Maria Coutinho, Eugénia Cruz, Sara Morais   +3 more
doaj   +1 more source

Immune thrombocytopenia secondary to primary cytomegalovirus infection after renal transplantation treated with a thrombopoietin receptor agonist: a case report. [PDF]

BMC Nephrol, 2023
Takehara T, Nishida H, Ichikawa K, Hosokawa Y, Nawano T, Takai S, Fukuhara H, Himuro M, Tsuchiya N, Watanabe M.   +9 more
europepmc   +1 more source

Avatrombopag, a promising novel thrombopoietin receptor agonist for refractory/relapsed/intolerant non-severe aplastic anemia: a phase 2 single-arm clinical trial. [PDF]

Ann Med, 2023
Wan Z, Chen M, Han B.
europepmc   +1 more source

Cerebral venous sinus thrombosis in immune thrombocytopenia patients treated with thrombopoietin receptor agonist: Case reports and literature review. [PDF]

Ann Med Surg (Lond), 2022
Teekaput C, Nadsasarn A, Tanprawate S, Soontornpun A, Thiankhaw K, Wantaneeyawong C, Teekaput K, Chai-Adisaksopha C.   +7 more
europepmc   +1 more source

Asymptomatic thrombocytopenia after nintedanib initiation in a patient with progressive pulmonary fibrosis: a case report and review of literature

Journal of Medical Case Reports
Background Nintedanib is a primary antifibrosing medication available for idiopathic pulmonary fibrosis, systemic sclerosis-interstitial lung disease, and progressive pulmonary fibrosis, with scattered report of drug-induced thrombocytopenia. Case report
Xinxin Zhang, Kan Zhang, Nannan Zhao, Na Xi, Tiemei Zhao   +4 more
doaj   +1 more source

Author Correction: Deciphering predictive factors for choice of thrombopoietin receptor agonist, treatment free responses, and thrombotic events in immune thrombocytopenia. [PDF]

Sci Rep, 2021
Lozano ML, Mingot-Castellano ME, Perera MM, Jarque I, Campos-Alvarez RM, González-López TJ, Carreño-Tarragona G, Bermejo N, Lopez-Fernandez MF, de Andrés A, Valcarcel D, Casado-Montero LF, Alvarez-Roman MT, Orts MI, Novelli S, Revilla N, González-Porras JR, Bolaños E, Rodríguez-López MA, Orna-Montero E, Vicente V.   +20 more
europepmc   +1 more source

A case of immune thrombocytopenia complicated by catastrophic antiphospholipid antibody syndrome and subsequent intramuscular haemorrhage

Journal of Medical Case Reports
Background Immune thrombocytopenia (ITP) and antiphospholipid syndrome (APS) are autoimmune disorders that may coexist, creating a challenging clinical scenario characterised by bleeding risk alongside paradoxically increased thrombotic risk ...
Priyanta Banerjee, David Allsup, Elizabeth Uglow, Corinna Hauff, Bryan Jason Atienza, Jireh Ann Batac   +5 more
doaj   +1 more source

A multicenter, randomized phase III trial of hetrombopag: a novel thrombopoietin receptor agonist for the treatment of immune thrombocytopenia. [PDF]

J Hematol Oncol, 2021
Mei H, Liu X, Li Y, Zhou H, Feng Y, Gao G, Cheng P, Huang R, Yang L, Hu J, Hou M, Yao Y, Liu L, Wang Y, Wu D, Zhang L, Zheng C, Shen X, Hu Q, Liu J, Jin J, Luo J, Zeng Y, Gao S, Zhang X, Zhou X, Shi Q, Xia R, Xie X, Jiang Z, Gao L, Bai Y, Li Y, Xiong J, Li R, Zou J, Niu T, Yang R, Hu Y.   +38 more
europepmc   +1 more source

Case Report: Prolonged thrombocytopenia after chemotherapy in solid tumors requiring long-term thrombopoietin receptor agonist support: a five-patient case series. [PDF]

Front Oncol
Wang S, Yu Y, Zhang L, Liu Q.
europepmc   +1 more source