Systemic Lupus Erythematosus with Refractory Immune Thrombocytopenia Progressing to Catastrophic Anti-Phospholipid Syndrome During Thrombopoietin Receptor Agonist Therapy: A Case Report. [PDF]
J Clin MedBackground/Objectives: Autoimmune thrombocytopenia is a common manifestation of systemic lupus erythematosus (SLE). Its main treatments are glucocorticoids, intravenous immunoglobulin, and immunosuppressants, but thrombopoietin mimetics may be considered
Chung SW, Ha YJ.
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Thrombopoietin Receptor Agonists for Treatment Thrombocytopenia in Dengue Fever [PDF]
, 2023 Dengue fever is considered to be the most prevalent mosquito - borne viral disease worldwide and has proven to be life - threatening at times. Thrombocytopenia occurs in mild and severe cases of dengue fever. commonly observed.
Sisilia, Adelina
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Thrombopoietin Receptor Agonist Exposure in Pregnancy: Not Always Without Fetal or Obstetric Complications [PDF]
Turkish Journal of HematologyUfuk Demirci, Mine Miskioğlu
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Peptide agonists of the thrombopoietin receptor [PDF]
Stem Cells, 1998 We have screened a variety of L-amino acid peptide libraries against the extracellular domain of the human thrombopoietin (HuTPO) receptor, c-Mpl. A large number of peptide ligands were recovered and categorized into two families. Peptides from each family compete with the binding of HuTPO and with the binding of peptides from the other familiy ...
W J, Dower +5 more
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Role of Thrombopoietin Receptor Agonists in Inherited Thrombocytopenia [PDF]
International Journal of Molecular Sciences, 2021 In the last decade, improvements in genetic testing have revolutionized the molecular diagnosis of inherited thrombocytopenias (ITs), increasing the spectrum of knowledge of these rare, complex and heterogeneous disorders. In contrast, the therapeutic management of ITs has not evolved in the same way.
José María Bastida +3 more
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Thrombopoietin receptor agonists in hereditary thrombocytopenias [PDF]
Journal of Thrombosis and Haemostasis, 2018 Hereditary thrombocytopenias (HTPs) constitute a heterogeneous group of diseases characterized by a reduction in platelet count and a potential bleeding risk. As a result of advances in diagnostic methods, HTPs are increasingly being identified, and appear to be less rare than previously thought.
Rodeghiero, F. +2 more
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Regulation of thrombopoietin receptor expression and function [PDF]
, 2004 Of the many cells in the body, the hematopoietic cells are among those with the highest rate of self-renewal and turnover. The production and destruction of these cells are tightly controlled by a number of hematopoietic growth factors, in particular by ...
Coers, Jörn
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The biology of thrombopoietin and thrombopoietin receptor agonists [PDF]
International Journal of Hematology, 2013 Thrombopoietin (TPO) is the major physiological regulator of platelet production. TPO binds the TPO receptor, activates JAK and STAT pathways, thus stimulating megakaryocyte growth and platelet production. There is no "sensor" of the platelet count; rather TPO is produced in the liver at a constant rate and cleared by TPO receptors on platelets.
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Thrombopoietin Receptor Agonists in Primary Immune Thrombocytopenia [PDF]
Seminars in Hematology, 2013 Thrombopoietin (TPO) regulates thrombopoiesis through activation of TPO receptors on the megakaryocyte cell surface, resulting in increased platelet production. The TPO receptor agonists are novel treatments for patients with chronic ITP aimed at increasing platelet production through interactions with the TPO receptor on megakaryocytes.
Deborah, Siegal +2 more
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Differential β-arrestin2 requirements for constitutive and agonist-induced internalization of the CB1 cannabinoid receptor [PDF]
, 2013 CB1 cannabinoid receptor (CB1R) undergoes both constitutive and agonist-induced internalization, but the underlying mechanisms of these processes and the role of beta-arrestins in the regulation of CB1R function are not completely understood.
Boros, Eszter +7 more
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