Results 31 to 40 of about 1,702,455 (203)
Tapering of the thrombopoietin receptor agonist in paediatric patients with chronic immune thrombocytopenia: Is it possible?
, 2022 20.500.12530/87857It is not clear if platelet responses are sustained after thrombopoietin receptor agonist (ar-TPO) withdrawal in paediatric patients.Rubén Berrueco, Dasí, María Ángeles, María Ángeles Dasí, Sastre, Ana, María Solsona, José Luís Dapena, Emilio Monteagudo, Monteagudo, Emilio, Solsona, María, Dapena, José Luís, Sebastián, Elena, Astigarraga, Itziar, Bienvenida Argilés, Cervera, Áurea, Berrueco, Rubén, Ana Sastre, Áurea Cervera, Elena Sebastián, Itziar Astigarraga, Argilés, Bienvenida +19 morecore +1 more sourceUse of Thrombopoietin Receptor Agonists in Pregnancy
Hematology/Oncology and Stem Cell Therapy, 2022 The management of immune thrombocytopenic purpura (ITP) involves several lines of therapy such as corticosteroids and intravenous immunoglobulin. With the emergence of novel therapies such as thrombopoietin receptor agonists (TPO-RAs), there has been a shift in treatment modalities.Jude, Howaidi, Abdullah M, AlRajhi, Ali, Howaidi, Fouad H, AlNajjar, Imran K, Tailor +4 moreopenaire +2 more sourcesA marine sponge-derived lectin reveals hidden pathway for thrombopoietin receptor activation
, 2022 N-glycan-mediated activation of the thrombopoietin receptor (MPL) under pathological conditions has been implicated in myeloproliferative neoplasms induced by mutant calreticulin, which forms an endogenous receptor-agonist complex that traffics to the ...Nakajima, Hiroya, Focia, Pamela J., Oshiro, Takumi, Sakai, Ryuichi, Tanaka, Yoshikazu, Kodera, Yoshio, Yokoyama, Takeshi, Masubuchi, Nami, Araki, Marito, Matsui, Takashi, Onodera, Kako, Komatsu, Norio, Ogawa, Tomohisa, Freymann, Douglas M., Watari, Hiromi, Hirayama, Makoto, Imai, Misa, Kageyama, Hiromu, Hori, Kanji +18 morecore +1 more sourceDevelopment of thrombopoietin receptor agonists for clinical use [PDF]
Journal of Thrombosis and Haemostasis, 2009 Thrombopoietin (TPO) is an essential hematopoietic cytokine for megakaryopoiesis. In 2002, we demonstrated that pegylated-recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) increased platelet counts in patients with chronic immune thrombocytopenic purpura (ITP) in a Phase I/II clinical trial.Y, Ikeda, Y, Miyakawaopenaire +2 more sourcesA Multi-Center Study on the Efficacy of Eltrombopag in Management of Refractory Chronic Immune Thrombocytopenia: A Real-Life Experience [PDF]
, 2019 Objective: The aim of the present study was to evaluate the efficacy and safety of eltrombopag, an oral thrombopoietin receptor agonist, in patients with chronic immune thrombocytopenia (ITP)Guven Cetin, Gokgoz, Zafer, Burak Deveci, Handan Haydaroglu Sahin, Emin Kaya, Reyhan Diz Kucukkaya, Aytan, Pelin, Akay Yanar, Olga Meltem, Undar, Levent, Atagündüz, Işık Kaygusuz, Atagunduz, Isik, Fusun Ozdemirkiran, Unal, Ali, Eser, Ali, Topts, Tayfur, Burhan Turgut, Mustafa Pehlivan, Melda Comert, Erman Ozturk, Ibrahim Haznedaroglu, Eorhan Ayyildiz, Sunu, Cenk, Acar, Kadir, Cetin, Guven, Kızılkılıç, Ebru, Yilmaz, Guven, Hasan Atilla Ozkan, Mehmet Turgut, Kizilkilic, Ebru, Gunduz, Mehmet, Ulku Ozan, Aydın, Demet, Esen, Ramazan, Sinem Namdaroglu, Ali Unal, Bahar Uncu Ulu, Funda Pepedil Tanrikulu, Sonmez, Mehmet, Funda Ceran, Tekinalp, Atakan, Cekdemir, Demet, Fadime Ersoy Dursun, Aslan, Vahap, Karakus, Abdullah, Eyup Naci Tiftik, Alanoglu, Guchan, Anil Tombak, Mehmet Sinan Dal, Ebru Kizilkilic, Sadrilo, Sevil, Figen Noyan, Tanrikulu, Funda Pepedil, Cenk Sunu, Ayer, Mesut, Ozatli, Duzgun, Bilgir, Oktay, Sucak, Eayhan Gulsan Turkoz, Murat Tombuloglu, Kiper, Demet, Teoman Soysal, Esra Ermis Turak, Firatli, Tulin Tuglular, Haznedaroğlu, İbrahim Celalettin, Ozkocaman, Vildan, Demet Cekdemir, Kaya, Emin, Ozet, Gulsum, Ozan, Ulku, Demircioglu, Sinan, Comert, Melda, Ozkan, Hasan Atilla, Payzın, Kadriye Bahriye, Fıratlı, Tülin Tuğlular, Ozcan, Muhit, Sadri, Sevil, Ozlu, Can, Dermenci, Hasan, Malkan, Umit Yavuz, Guven Yilmaz, Zafer Gokgoz, Sehmus Ertop, Özdemirkıran, Füsun Gediz, Türköz Sucak, Ayhan Gülsan, Gulsum Ozet, Yanar, Olga Meltem Akay, Ayyildiz, Eorhan, Sucak, Ayhan Gülsan Türköz, Namdaroglu, Sinem, Alacacioglu, Inci, Yenerel, Mustafa, Umit Yavuz Malkan, Noyan, Figen, Guray Saydam, Payzin, Kadriye Bahriye, Yılmaz, Güven, Diz Küçükkaya, Reyhan, Sahin, Handan Haydaroglu, Haznedaroglu, Ibrahim, Demet Aydin, Ertop, Sehmus, Sinan Demircioglu, Ali Eser, Levent Undar, Dal, Mehmet Sinan, Haydaroğlu Şahin, Handan, Erikci, Alev Akyol, Duzgun Ozatli, Demir, Ahmet Muzaffer, Pepedil Tanrıkulu, Funda, Uncu Ulu, Bahar, Alev Akyol Erikci, Dursun, Fadime Ersoy, Pinar Tarkun, Inci Alacacioglu, Tarkun, Pınar, Olga Meltem Akay Yanar, Aslaner, Muzeyyen, Guchan Alanoglu, Abdullah Karakus, Vahap Aslan, Nevin Alayvaz, Andic, Neslihan, Tayfur Topts, Cetiner, Mustafa, Ozen, Mehmet, Atagündüz, Işık, Kadriye Bahriye Payzin, Hatice Terzi, Isik Atagunduz, Akyol Erikçi, Alev, Saydam, Guray, Özatlı, Düzgün, Ahmet Muzaffer Demir, Ayyıldız, Orhan, Mustafa Cetiner, Muhit Ozcan, Ermiş Turak, Esra, Tarkun, Pinar, Alayvaz, Nevin, Ozan Salim, Serkan Guvenc, Kadir Acar, Selim Bapur, Derya, Alacacıoğlu, İnci, Tulin Tuglular Firatli, Turak, Esra Ermis, Yenerel, Mustafa Nuri, Mehmet Sencan, Ceran, Funda, Atakan Tekinalp, Tombuloğu, Murat, Terzi, Hatice, Ünal, Ali Ekrem, Tanrıkulu, Funda Pepedil, Derya Selim Bapur, Mesut Ayer, Tuğlular Fıratlı, Tülin, Volkan Karakus, Ozkan Sayan, Pelin Aytan, Aydin, Demet, Sencan, Mehmet, Eayhan Gulsan Turkoz Sucak, Pehlivan, Mustafa, Can Ozlu, Ramazan Esen, Tombak, Anıl, Mustafa Yenerel, Ozdemirkiran, Fusun, Sayan, Ozkan, Özdemirkıran, Füsun, Turgut, Mehmet, Hasan Dermenci, Deveci, Burak, Ozcan, Mehmet Ali, Özet, Gülsüm Gulistan, Tombuloglu, Murat, Mehmet Sonmez, Atilla, Erden, Andıç, Neslihan, Kucukkaya, Reyhan Diz, Tombak, Anil, Toptaş, Tayfur, Oktay Bilgir, Karakus, Volkan, Guvenc, Serkan, Ozturk, Erman, Erden Atilla, Soysal, Teoman, Muzeyyen Aslaner, Turgut, Burhan, Tiftik, Eyup Naci, Demet Kiper, Ulu, Bahar Uncu, Vildan Ozkocaman, Neslihan Andic, Sevil Sadrilo, Salim, Ozan, Ersoy Dursun, Fadime, Mehmet Ali Ozcan, Bapur, Derya Selim +200 morecore +1 more sourceMutant Calreticulin Requires Both Its Mutant C-terminus and the Thrombopoietin Receptor for Oncogenic Transformation [PDF]
, 2016 Somatic mutations in calreticulin (CALR) are present in approximately 40% of patients with myeloproliferative neoplasms (MPN), but the mechanism by which mutant CALR is oncogenic remains unclear.Schneider, RK, Losman, JA, Perales-Patón, J., Tothova, Z., Peskier, F., Mullally, A., Losman, J.A., Giannini, S, Al-Shahrour, F, Chen, E, Rosen, EA, Chen, E., Al-Shahrour, F., Giannini, S., Ko, A, Elf, S, Abdelfattah, N.S., Wolach, O., Morgan, E.A., Schneider, R.K., Florescu, N, Mullally, A, Elf, S., Florescu, N., Wolach, O, Morgan, EA, Ko, A., Peisker, F, Perales-Patón, J, Tothova, Z, Abdelfattah, NS, Rosen, E.A. +31 morecore +1 more sourceSafety, tolerance, pharmacokinetic and pharmacodynamic properties of thrombopoietin mimetic peptide for injection in Chinese healthy volunteers: a randomized, placebo-controlled, double-blind study
Platelets, 2022 The thrombopoietin mimetic peptide for injection is a second-generation thrombopoietin receptor agonist (TPO-RA) used in the treatment of patients with immune thrombocytopenia.Xiao-Yan Sheng, Zhi-Yan Liu, Jing Zhao, Lei Song, Wen-Ming Zhao, Xia Zhao, Yi-Min Cui +6 moredoaj +1 more source
