Results 71 to 80 of about 3,260 (169)

Eltrombopag inhibits TET dioxygenase to contribute to hematopoietic stem cell expansion in aplastic anemia

The Journal of Clinical Investigation, 2022
Eltrombopag, an FDA-approved non-peptidyl thrombopoietin receptor agonist, is clinically used for the treatment of aplastic anemia, a disease characterized by hematopoietic stem cell failure and pancytopenia, to improve platelet counts and stem cell ...
Yihong Guan, Metis Hasipek, Dongxu Jiang, Anand D. Tiwari, Dale R. Grabowski, Simona Pagliuca, Sunisa Kongkiatkamon, Bhumika Patel, Salendra Singh, Yvonne Parker, Thomas LaFramboise, Daniel Lindner, Mikkael A. Sekeres, Omar Y. Mian, Yogen Saunthararajah, Jaroslaw P. Maciejewski, Babal K. Jha   +16 more
doaj   +1 more source

Thrombopoietin-receptor agonists in haematological disorders: The Danish experience

Platelets, 2011
The objective of this study was to investigate the use of thrombopoietin-receptor agonists (TPO-ra) in patients with refractory primary immune thrombocytopenia (ITP) as well as off-label use of TPO-ra in Danish haematology departments. Hospital medical records from 32 of the 39 patients having received TPO-ra from 2009 to 1 May 2011 were available for ...
Gudbrandsdottir, S., Hasselbalch, H., Frederiksen, H.   +2 more
openaire   +3 more sources

Pragmatic Clinical Trial of Fostamatinib as Second‐Line Therapy in Adult Patients With Immune Thrombocytopenia and Insufficient Response to Prior Therapy: The Fostamatinib FORTE Trial

eJHaem, Volume 7, Issue 4, August 2026.
Amber Afzal, Robert Kribs, Sumit Sawhney, Mohit Narang, Frances Blevins, Robert Numerof, Francois Di Trapani, Sherry Ladha, Ruchika Goel   +8 more
wiley   +1 more source

This Is Not a Myeloproliferative Neoplasm…

Pediatric Blood &Cancer, Volume 73, Issue 7, July 2026.
Stephanie Juané Kennedy
wiley   +1 more source

Novel Perspectives on Thrombopoietin Receptor Agonists Applications

Hämostaseologie
Abstract Second-generation thrombopoietin receptor agonists (TPO-RAs), romiplostim, eltrombopag, and avatrombopag, have been proved to be significant stimulators of megakaryopoiesis and, in the last decade, they have been incorporated in the treatment options against refractory immune thrombocytopenia in children and adults that do ...
Stafylidis, Christos, Vlachopoulou, Dimitra, Syriopoulou, Stavroula, Chatzidavid, Sevastianos, Viniou, Nora-Athina   +4 more
openaire   +3 more sources

Repurposing the thrombopoietin receptor agonist eltrombopag as an anticryptococcal agent

Medical Mycology, 2019
AbstractIn this study, a Food and Drug Administration (FDA)-approved drug with previously unreported antifungal activity was investigated for suitability for use as an anticryptococcal agent. First, we screened a compound library of 1018 FDA-approved drugs against Cryptococcus neoformans.
Ying-Lien Chen, Sheng-Yung Yang, Li-Hang Hsu, Hao-Tai Ko   +3 more
openaire   +3 more sources

Use of Thrombopoietin Receptor Agonists in Severe Aplastic Anemia During Pregnancy: A Case Report

Immuno
Severe aplastic anemia (SAA) in pregnancy represents a rare but life-threatening clinical challenge. Standard therapies such as hematopoietic stem cell transplantation (HSCT) and immunosuppressive therapy are limited during pregnancy due to safety ...
Mostafa F. Mohammed Saleh, Ahemd Kotb Abrabou, Abdulrahman Nasiri, Alfadil Haroon, Mahmoud Aljurf   +4 more
doaj   +1 more source

The Use of Thrombopoietin Receptor Agonists for Correction of Thrombocytopenia prior to Elective Procedures in Chronic Liver Diseases: Review of Current Evidence

International Journal of Hepatology, 2016
Patients with chronic liver diseases (CLD) undergo a range of invasive procedures during their clinical lifetime. Various hemostatic abnormalities are frequently identified during the periprocedural work-up; including thrombocytopenia.
Kamran Qureshi, Shyam Patel, Andrew Meillier   +2 more
doaj   +1 more source

Role of romiplostim in splenectomized and nonsplenectomized patients with immune thrombocytopenia

ImmunoTargets and Therapy, 2016
Jose Perdomo Hematology Research Unit, St George and Sutherland Clinical School, University of New South Wales, Kogarah, NSW, Australia Abstract: Romiplostim is a thrombopoietin receptor agonist (TPO-RA) used for the treatment of adult primary immune ...
Perdomo J
doaj  

Data mining and safety analysis of avatrombopag: a retrospective pharmacovigilance study based on the US food and drug administration’s adverse event reporting system

Scientific Reports
With its increasing use in the treatment of thrombocytopenia, avatrombopag’s associated adverse events (AEs) pose a major challenge to its clinical application. This study aims to comprehensively study AEs associated with avatrombopag by using real-world
Hong Zhu, Meng Wu
doaj   +1 more source