Results 1 to 10 of about 498,238 (269)

Designing ATHN 7: Safety, effectiveness and practice of treatment of people with haemophilia in the United States through a natural history cohort study

The Journal of Haemophilia Practice, 2023
Haemophilia A and B are X-linked inherited bleeding disorders, resulting in the deficiency of clotting factor VIII and IX, respectively. Since the introduction of recombinant clotting factor concentrates in the early 1990s, the major safety concern for ...
Buckner Tyler W., Daoud Nabil, Miles Moses, O'Neill Carrie, Watson Crystal, Recht Michael   +5 more
doaj   +1 more source

The use of infrared thermography for non-invasive detection of bleeding and musculoskeletal abnormalities in patients with hemophilia: an observational study

Thrombosis Journal, 2023
Background In patients with hemophilia (PwH), bleeding often occurs in joints and muscles, and early detection of hemorrhage is important to prevent the onset and progression of mobility impairment.
Ryohei Kawasaki, Asuka Sakata, Chihiro Hosoda, Suguru Harada, Tetsuhiro Soeda, Yukiko Nishida, Naoki Matsumoto, Kohei Tatsumi, Keiji Nogami, Yasushi Yoshimura, Midori Shima   +10 more
doaj   +1 more source

Vaccine-induced immune thrombotic thrombocytopenia following AstraZeneca (ChAdOx1 nCoV-19) vaccine: report of two cases

Bleeding, Thrombosis and Vascular Biology, 2022
Vaccination with ChAdOx1 nCoV-19 can result in vaccine-induced immune thrombotic thrombocytopenia (VITT). This phenomenon mimics heparin-induced thrombocytopenia, yet it does not require heparin as a trigger.
Rita Carlotta Santoro, Roberto Minici, Marzia Leotta, Mariapia Falbo, Lucia Concetta Elia, Francesca Leo, Antonella Ierardi, Alessandra Strangio, Simona Prejanò   +8 more
doaj   +1 more source

Body temperature and mouse scoring systems as surrogate markers of death in cecal ligation and puncture sepsis

Intensive Care Medicine Experimental, 2018
Background Despite increasing ethical standards for conducting animal research, death is still often used as an endpoint in mouse sepsis studies. Recently, the Murine Sepsis Score (MSS), Mouse Clinical Assessment Score for Sepsis (M-CASS), and Mouse ...
Safiah H. C. Mai, Neha Sharma, Andrew C. Kwong, Dhruva J. Dwivedi, Momina Khan, Peter M. Grin, Alison E. Fox-Robichaud, Patricia C. Liaw   +7 more
doaj   +1 more source

Evaluation of platelet function in thrombocytopenia

Platelets, 2018
Whole blood aggregometry is a functional assay for determination of platelet function. Until now, whole blood aggregometry has not been considered feasible at low platelet counts.
Mette Tiedemann Skipper, Peter Rubak, Jesper Stentoft, Anne-Mette Hvas, Ole Halfdan Larsen   +4 more
doaj   +1 more source

Potency Adjusted Blended Heparin of Bovine, Ovine, and Porcine Heparin Exhibit Comparable Biologic Effects to Referenced Single-Sourced Porcine Heparin

Clinical and Applied Thrombosis/Hemostasis, 2023
Introduction: Bovine and ovine mucosa represent alternate anticoagulants to porcine mucosa for production of unfractionated heparin (UFH). Standardized heparins from various sources can be blended and potency adjusted, blended heparins exhibit comparable
Guy Olson BS, Walter Jeske PhD, Omer Iqbal MD, Emily Krupa BS, Amber Farooqui MD, Fakiha Siddiqui BDS, Debra Hoppensteadt PhD, Ahmed Kouta PhD, Jawed Fareed PhD   +8 more
doaj   +1 more source

Comparison of Long-Acting G-CSF (PD-Lasta) with Short-Acting G-CSF (PD-Grastim) in Neutrophil Recovery Following Consolidation Chemotherapy with High-Dose Cytarabine in Acute Myeloid Leukemia: A Randomized Clinical Trial

International Journal of Hematology-Oncology and Stem Cell Research, 2021
Background: Acute myeloid leukemia (AML) patients are often neutropenic as a result of their disease alone or following their chemotherapy. In this randomized clinical trial the efficacy of Iranian short-acting (PD-Grastim) and long-acting G-CSF (PD ...
Mohsen Esfandbod, Fatemeh Agha barazadeh, Mona Faraz, Fariba Zarrabi, Gholamreza Toogeh   +4 more
doaj   +1 more source

Functional Genomics for the Identification of Modulators of Platelet-Dependent Thrombus Formation

TH Open, 2018
Despite the absence of the genome in platelets, transcription profiling provides important insights into platelet function and can help clarify abnormalities in platelet disorders.
Elien Vermeersch, Benedicte P. Nuyttens, Claudia Tersteeg, Katleen Broos, Simon F. De Meyer, Karen Vanhoorelbeke, Hans Deckmyn   +6 more
doaj   +1 more source

Global coagulation assays in hemophilia A: A comparison to conventional assays

Research and Practice in Thrombosis and Haemostasis, 2020
Background Global assays measure the interactions of coagulants, anticoagulants, and platelets on thrombin generation and may reflect the comprehensive coagulation potential in patients with hemophilia better than conventional assays.
Saman Aghighi, Anne Riddell, Christine A. Lee, Simon A. Brown, Edward Tuddenham, Pratima Chowdary   +5 more
doaj   +1 more source

PATIENTS REFERRED FOR BLEEDING SYMPTOMS OF UNKNOWN CAUSE: DOES EVALUATION OF THROMBIN GENERATION CONTRIBUTE TO DIAGNOSIS?

Mediterranean Journal of Hematology and Infectious Diseases, 2016
Introduction Patients with mild to moderate bleeding symptoms referred for coagulation investigation sometimes never receive a definitive diagnosis. Bleed assessment tools have been developed and validated to assess the severity of symptoms.
Elena Holm, Eva Zetterberg, Susanna Lövdahl, Erik Berntorp   +3 more
doaj   +1 more source