Results 21 to 30 of about 523,717 (316)

Targeting platelet-derived CXCL12 impedes arterial thrombosis. [PDF]

, 2022
The prevention and treatment of arterial thrombosis remains a clinical challenge and understanding the relevant molecular mechanisms in detail may facilitate the quest to identify novel targets and therapeutic approaches that improve protection from ...
Megens, Remco T. A., Agten, Stijn M., Blanchet, Xavier, Duchene, Johan, Mayo, Kevin H, Agten, Stijn M, Brandl, Richard, Heemskerk, Johan W. M., Leberzammer, Julian, Hackeng, Tilman M; id_orcid, Mayo, Kevin H., Weber, Christian, Jooss, Natalie Jasmin, Zhang, Pengyu, Jooss, Natalie J., Aslani, Maria, Stark, Konstantin, Megens, Remco T A, Duan, Rundan, Hundelshausen, Philipp von, Jurk, Kerstin, Hackeng, Tilman M., Agten, Stijn M; id_orcid, Schulz, Christian, Döring, Yvonne, von Hundelshausen, Philipp, Heemskerk, Johan W M, Ippel, Hans, Hackeng, Tilman M, Siess, Wolfgang   +29 more
core   +1 more source

PATIENTS REFERRED FOR BLEEDING SYMPTOMS OF UNKNOWN CAUSE: DOES EVALUATION OF THROMBIN GENERATION CONTRIBUTE TO DIAGNOSIS?

Mediterranean Journal of Hematology and Infectious Diseases, 2016
Introduction Patients with mild to moderate bleeding symptoms referred for coagulation investigation sometimes never receive a definitive diagnosis. Bleed assessment tools have been developed and validated to assess the severity of symptoms.
Elena Holm, Eva Zetterberg, Susanna Lövdahl, Erik Berntorp   +3 more
doaj   +1 more source

Thrombosis in atherogenesis

Critical Reviews in Oncology/Hematology, 1989
This review addresses the question of the involvement of fibrin in the development of atherosclerotic plaques. Numerous studies in the older literature demonstrated the presence of fibrinogen and/or fibrin in plaques, but the techniques that were available (mainly immunochemistry and immunohistochemistry with polyclonal antifibrinogen antibodies) did ...
Karen L. Kaplan, Alessandra Bini, Laurence A. Harker   +2 more
openaire   +2 more sources

Neutrophil extracellular traps and cancer-associated thrombosis

, 2022
The hypercoagulable state associated with malignancy is well described. However, the mechanisms by which tumors cause this hypercoagulable state are yet to be fully understood.
Mackman, N, Mackman, Nigel, Rosell, Axel, Martinod, Kimberly, Martinod, K, Thalin, C, Thålin, Charlotte, Rosell, A,   +7 more
core   +1 more source

Patients with Essential thrombocythaemia have an increased prevalence of antiphospholipid antibodies which may be associated with thrombosis

, 2002
A significant proportion of patients with Essential Thrombocythaemia (ET) have thrombotic complications which have an important impact upon the quality, and duration of their life.
Machin, S.J., C.N. Harrison, P. Carr, Mackie, I., Donohoe, S., S.J. Machin, S. Donohoe, I. Mackie, M. Dave, Harrison, C.N., Dave, M., Carr, P.   +11 more
core   +1 more source

Proteomics in thrombosis research [PDF]

, 2022
A State of the Art lecture titled “Proteomics in Thrombosis Research” was presented at the ISTH Congress in 2021. In clinical practice, there is a need for improved plasma biomarker-based tools for diagnosis and risk prediction of venous thromboembolism (
Iglesias, Maria Jesus, Edfors, Fredrik,, Odeberg, Jacob,, Iglesias, Maria Jesus,, Edfors, Fredrik, Butler, Lynn M.,, Butler, Lynn, Odeberg, Jacob   +7 more
core   +1 more source

Gut Microbiota Promote Angiotensin II–Induced Arterial Hypertension and Vascular Dysfunction

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016
Background The gut microbiome is essential for physiological host responses and development of immune functions. The impact of gut microbiota on blood pressure and systemic vascular function, processes that are determined by immune cell function, is ...
Susanne H. Karbach, Tanja Schönfelder, Ines Brandão, Eivor Wilms, Nives Hörmann, Sven Jäckel, Rebecca Schüler, Stefanie Finger, Maike Knorr, Jeremy Lagrange, Moritz Brandt, Ari Waisman, Sabine Kossmann, Katrin Schäfer, Thomas Münzel, Christoph Reinhardt, Philip Wenzel   +16 more
doaj   +1 more source

Emicizumab initiation and bleeding outcomes in people with hemophilia A with and without inhibitors: A single‐center report

Research and Practice in Thrombosis and Haemostasis, 2021
Background Emicizumab, a bispecific antibody factor VIII mimetic, is approved for prophylaxis in hemophilia, and has different risks and side effects compared to factor VIII products.
Beth Boulden Warren, Adrian Chan, Marilyn Manco‐Johnson, Brian R. Branchford, Tyler W. Buckner, Genevieve Moyer, Elizabeth Gibson, Dianne Thornhill, Michael Wang, Christopher J Ng   +9 more
doaj   +1 more source

Supraclavicular node metastasis presenting with internal jugular vein thrombosis [PDF]

, 1989
A case of internal jugular vein thrombosis secondary to compression by a metastasis in Virchow’s node and the investigations leading to the diagnosis is described.
Brincat, Stephen
core  

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source