Results 81 to 90 of about 131,342 (265)

Prognostic factors in thrombotic thrombocytopenic purpura

Türk Biyokimya Dergisi, 2022
Thrombotic thrombocytopenic purpura (TTP) is a rare thrombotic microangiopathy with no standardized prognostic model to predict mortality. The aim of the study is to determine parameters associated with TTP-related mortality.
Yalçıner Merih, İlhan Osman
doaj   +1 more source

Thrombotic Microangiopathy Complicating Cyclosporine in Renal Transplant Patients

Advanced Medical Journal, 2023
Background and objectives: Experience with cyclosporine associated thrombotic microangiopathy in renal allograft recipients is generally anecdotal; detailed descriptions of clinical behavior, therapeutic options and experience are also anecdotal and few.
Safa Al-Mukhtar
doaj   +1 more source

Endothelial injury and thrombotic microangiopathy in COVID-19: Treatment with the lectin-pathway inhibitor narsoplimab

Immunobiology, 2020
In COVID-19, acute respiratory distress syndrome (ARDS) and thrombotic events are frequent, life-threatening complications. Autopsies commonly show arterial thrombosis and severe endothelial damage. Endothelial damage, which can play an early and central
A. Rambaldi, G. Gritti, M. Mico', M. Frigeni, G. Borleri, A. Salvi, F. Landi, C. Pavoni, A. Sonzogni, A. Gianatti, F. Binda, S. Fagiuoli, F. Di Marco, L. Lorini, G. Remuzzi, S. Whitaker, G. Demopulos   +16 more
semanticscholar   +1 more source

Thrombotic microangiopathy secondary to Capnocytophaga canimorsus bacteremia

Iberoamerican Journal of Medicine, 2023
Capnocytophaga canimorsus is an Anaerobic Gram-Negative bacterium present in the oral microbiology of cats and dogs. It can produce infections in humans, being capable of causing severe complications with the development of septic shock.
Enrique Chicote-Álvarez, Javier Larreina-Pérez, Ada Esteban-Figuerola, Prisma Monserrat Hernández-Pérez, Isabel Mainar-Gil, Sergio Gómez-Camino, Adolfo Íñiguez-de Diego, Elisa Monfort-Lázaro, Íñigo Gastón-Najarro, Miriam Díez-Sáez   +9 more
doaj   +1 more source

Pathophysiology of SARS-CoV-2: targeting of endothelial cells renders a complex disease with thrombotic microangiopathy and aberrant immune response. The Mount Sinai COVID-19 autopsy experience

medRxiv, 2020
BACKGROUND Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) and its associated clinical syndrome COVID-19 are causing overwhelming morbidity and mortality around the globe, disproportionately affecting New York City.
C. Bryce, Z. Grimes, E. Pujadas, Sadhna Ahuja, M. Beasley, R. Albrecht, Tahyna Hernandez, A. Stock, Zhen Zhao, M. A. Al Rasheed, Joyce Chen, Li Li, Di Wang, A. Corben, K. Haines, William Westra, M. Umphlett, Ronald E. Gordon, J. Reidy, B. Petersen, F. Salem, M. Fiel, S. E. El Jamal, N. Tsankova, J. Houldsworth, Zarmeen M Mussa, Wen-Chun Liu, Brandon Veremis, E. Sordillo, M. Gitman, M. Nowak, R. Brody, N. Harpaz, M. Merad, S. Gnjatic, Ryan Donnelly, Patricia Seigler, C. Keys, J. Cameron, I. Moultrie, Kae-Lynn Washington, J. Treatman, R. Sebra, J. Jhang, A. Firpo, J. Lednicky, A. Paniz‐Mondolfi, C. Cordon-Cardo, M. Fowkes   +48 more
semanticscholar   +1 more source

Bringing Gene Therapy Into Real World Clinical Practice

Haemophilia, EarlyView.
ABSTRACT Introduction Adeno‐associated virus (AAV)‐based gene therapy for haemophilia has shifted therapeutic paradigms by enabling hepatic gene transfer, restoring endogenous clotting factor expression, and reducing reliance on conventional prophylactic treatments. Two products, valoctocogene roxaparvovec (haemophilia A) and etranacogene dezaparvovec (
Wolfgang Miesbach, Pratima Chowdary, Margareth C. Ozelo   +2 more
wiley   +1 more source

Case Report: Scleroderma Renal Crisis Presenting as Thrombotic Microangiopathy

Turkish Journal of Nephrology, 2019
Scleroderma is a systemic autoimmune disease of unknown origin characterized by excessive deposition of collagen and other connective tissue macromolecules in multiple organs. It can cause thrombotic microangiopathy.
Mehmet Can UĞUR, Ferhat EKİNCİ, Tuğba KARADENİZ, Elif GRAM, Hülya ÇOLAK, Cengiz CEYLAN, Harun AKAR   +6 more
doaj  

Interferon-complement loop in transplant-associated thrombotic microangiopathy.

Blood Advances, 2020
Transplant-associated thrombotic microangiopathy (TA-TMA) is an important cause of morbidity and mortality after hematopoietic stem cell transplantation (HSCT). The complement inhibitor eculizumab improves TA-TMA, but not all patients respond to therapy,
S. Jodele, M. Medvedovic, Nathan Luebbering, Jenny Chen, C. Dandoy, B. Laskin, S. Davies   +6 more
semanticscholar   +1 more source

FVIIIa Mimetics: New Approaches and Next‐Generation Initiatives

Haemophilia, EarlyView.
ABSTRACT Emicizumab has revolutionized hemophilia A care, yet limitations regarding the “ceiling” of hemostatic efficacy (equivalent to mild hemophilia) and global access persist. This review critically examines two distinct paradigms shaping the future of care: Innovation and Access. Regarding innovation, we synthesize the latest clinical data on next‐
Tadashi Matsushita, Keiji Nogami, Chandrakala Shanmukhaiah   +2 more
wiley   +1 more source

Thrombotic Thrombocytopenic Microangiopathy

Počki, 2013
Визначення поняття Тромботична тромбоцитопенічна мікроангіопатія (ТМА) — судинне ураження (переважно артеріол і капілярів) різних органів унаслідок ушкодження ендотелію та оклюзія просвіту судин тромбоцитарними тромбами.
O.I. Taran
doaj   +1 more source