Results 91 to 100 of about 17,380 (208)

Shifting From Systemic to Precision‐Targeted Complement Therapies: Opportunities and Hurdles

European Journal of Immunology, Volume 56, Issue 6, June 2026.
Complement therapeutics have expanded considerably, but systemic inhibitors remain limited by infection risks, breakthrough events, and loss of physiological functions. Emerging targeted approaches aim for organ‐, tissue‐, or cell‐specific modulation of complement activity, potentially offering greater precision while reducing treatment burden and ...
Marco Mannes, Wioleta M. Zelek, Leendert A. Trouw   +2 more
wiley   +1 more source

Therapeutic Plasma Exchange in the Elderly: Rare Indications but Good Tolerability

Journal of Clinical Apheresis, Volume 41, Issue 3, June 2026.
ABSTRACT Therapeutic plasma exchange (TPE) is used for a wide range of indications and is associated with well‐described adverse events. However, no study has specifically focused on tolerance in elderly patients, despite its expected increasing use in this population. We conducted a single‐center retrospective case–control study of all patients aged ≥ 
Valentin Coirier, Quentin Quelven, Pauline Guillot, Elie Jalaber, Floriane L’Her, Vincent Joussellin, Félicie Bélicard, Kieran Pinceaux, Adel Maamar, Mathieu Lesouhaitier, Jean‐Marc Tadié, Nicolas Terzi   +11 more
wiley   +1 more source

Current Status of Kidney Xenotransplantation in Basic Research

Organ Medicine, Volume 3, Issue 2, Page 87-101, June 2026.
Kidney xenotransplantation is a potential solution to the organ shortage for end‐stage kidney disease. This review systematically elaborates on the application advances of donor pig gene editing technologies, the molecular mechanisms and regulatory strategies of xenogeneic immune rejection, and the optimization approaches of immune compatibility ...
Yu Luo, Bingzhuo Liu, Weijie Lai
wiley   +1 more source

Clinical Images: Thrombocytopenia, anasarca, fever, reticulin fibrosis, and organomegaly syndrome presenting as bilateral adrenal hemorrhage

ACR Open Rheumatology, Volume 8, Issue 6, June 2026.
Masaki Itagane, Mitsuyo Kinjo
wiley   +1 more source

Ventilation Intensity and Prognosis in Pediatric Oncology: Mechanical Power, Compliance, and Mortality Risk

Pediatric Pulmonology, Volume 61, Issue 6, June 2026.
ABSTRACT Background Mechanical power (MP) and dynamic compliance (Cdyn) are key determinants of ventilator‐induced lung injury (VILI) and mortality. This study aimed to identify variables associated with MP and Cdyn and evaluate their impact on mortality and ventilator‐free days (VFD) in critically ill children with cancer.
Bruno Sanchez Camargo, Gabriela Maria Virgílio Dias Santos, Orlei Ribeiro de Araujo, Carolina Oberg Ribeiro, Dafne Cardoso Bourguignon da Silva   +4 more
wiley   +1 more source

Thrombotic microangiopathy associated with use of interferon-beta

International Journal of Nephrology and Renovascular Disease, 2012
Teresa Olea,1 Raquel Díaz-Mancebo,1 Maria-Luz Picazo,2 Jorge Martínez-Ara,1 Angel Robles,3 Rafael Selgas,11Departments of Nephrology, 2Pathology, 3Internal Medicine, Hospital Universitario La Paz, Madrid, SpainAbstract: Interferon ...
Robles A, Martinez-Ara J, Picazo ML, Diaz-Mancebo R, Olea T, Selgas R   +5 more
doaj  

Thrombotic microangiopathy and their mimickers

Nephrology Dialysis Transplantation, 2020
Lilian Monteiro P Palma, Sanjeev Sethi
openaire   +2 more sources

Renal dysfunction in symptomatic Waldenström macroglobulinaemia: A nationwide Italian multicentre study

British Journal of Haematology, Volume 208, Issue 6, Page 2059-2068, June 2026.
Renal dysfunction represents a possible underrecognized complication of symptomatic WM; this condition correlates with adverse global and disease‐specific clinical outcomes. Summary The prognostic significance of impaired renal function in Waldenström macroglobulinaemia (WM) remains poorly defined.
Nicolò Danesin, Francesco Autore, Anna Maria Frustaci, Gianmarco Favrin, Emanuele Cencini, Alessandro Noto, Irene Dogliotti, Jacopo Olivieri, Marcello Riva, Isacco Ferrarini, Anna Maria Barbui, Sara Steffanoni, Dario Marino, Benedetta Puccini, Piero Maria Stefani, Rita Rizzi, Michele Merli, Angela Ferrari, Stefano Luminari, Carlo Visco, Livio Trentin, Andrea Visentin, Annarita Conconi, Simone Ferrero, Marzia Varettoni, Alessandra Tedeschi, Luca Laurenti, Francesco Piazza   +27 more
wiley   +1 more source

Tacrolimus Concentration/Dose Ratio in Hematopoietic Cell Transplantation Recipients: An Exploratory Study of Metabolizer Phenotyping and Clinical Outcomes

Clinical and Translational Science, Volume 19, Issue 6, June 2026.
ABSTRACT Tacrolimus pharmacokinetics shows wide interindividual variability after allogeneic hematopoietic cell transplantation (HCT), potentially influencing both effectiveness and toxicity. The concentration‐to‐dose (C/D) ratio has been proposed as a simple surrogate marker of tacrolimus metabolism, enabling patient stratification into fast or slow ...
Luiz Carlos da Costa‐Junior, Rita de Cássia Barbosa da Silva Tavares, Marina Izu, Simone Cunha Maradei, Maria Claudia Rodrigues Moreira, Marta Colares Nogueira, Décio Lerner, Teresa de Souza Fernandez, Paulo Caleb Júnior Lima Santos   +8 more
wiley   +1 more source

Common Hematologic Emergencies—Acute Promyelocytic Leukemia and Microangiopathic Hemolytic Anemias—A Pivotal Role of Clinical Laboratory

International Journal of Laboratory Hematology, Volume 48, Issue 3, Page 521-530, June 2026.
ABSTRACT Hematologic emergencies are urgent health conditions which result in significant mortality and morbidity unless timely therapeutic measures are taken. Therapeutic success depends on their timely and accurate recognition by hematology laboratory services.
Ganna Shestakova, Nicolas Ulrich Edgar, Anton V. Rets   +2 more
wiley   +1 more source