Results 221 to 230 of about 49,034 (266)

Recombinant ADAMTS13 in Congenital Thrombotic Thrombocytopenic Purpura.

New England Journal of Medicine
BACKGROUND Congenital thrombotic thrombocytopenic purpura (TTP) results from severe hereditary deficiency of ADAMTS13. The efficacy and safety of recombinant ADAMTS13 and standard therapy (plasma-derived products) administered as routine prophylaxis or ...
M. Scully, A. Antun, S. Cataland, P. Coppo, C. Dossier, N. Biebuyck, W. Hassenpflug, K. Kentouche, Paul N Knöbl, J. K. Kremer Hovinga, M. López-Fernández, M. Matsumoto, T. Ortel, J. Windyga, Indranil Bhattacharya, M. Cronin, Hong Li, Björn Mellgård, Munjal Patel, P. Patwari, S. Xiao, Pinghai Zhang, Linda T. Wang   +22 more
semanticscholar   +1 more source

THROMBOTIC THROMBOCYTOPENIC PURPURA

Annals of Internal Medicine, 1953
Excerpt Thrombotic thrombocytopenic purpura is a rare disease of which only a few cases have been diagnosed ante mortem.4Because of the rarity of diagnosis, other than at the autopsy table, few lab...
W S, GREEN, T W, GREEN
openaire   +2 more sources

Thrombotic thrombocytopenic purpura

The Journal of Maternal-Fetal & Neonatal Medicine, 2012
A 34-year old primipara was admitted to hospital with dichorionic-diamniotic twins in 26+3 weeks of gestation. In suspicion of HELLP-syndrome, caesarean section was performed at 27+4 weeks of gestation, because of platelet count was reduced to 44000/µl. A re-laparotomy had to be performed because of intra-abdominal bleedings.
Charlotte, Kaiser, Ulrich, Gembruch, Viktor, Janzen, Anne-Sybil, Gast   +3 more
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Thrombotic Thrombocytopenic Purpura

Thrombosis and Haemostasis, 1995
Recent studies indicate that CRTTP patients have excessive shear stress-induced platelet aggregation that is associated with the presence of ULvWF multimers in their plasma and increased vWF-binding to their platelets by flow cytometry. In these CRTTP patients, relapses, excessive shear-aggregation and the presence in their plasma of ULvWF forms are ...
openaire   +2 more sources

Autoimmunity in Thrombotic Thrombocytopenic Purpura

Seminars in Thrombosis and Hemostasis, 2005
In the last few years, an autoimmune hypothesis for the pathogenesis of thrombotic thrombocytopenic purpura (TTP) has been proposed often, with variable success because of inconsistent supporting data. We are now aware that at least one subgroup of TTP patients does present with pathogenic autoantibodies (i.e, anti-ADAMTS13); this group consequently is
Porta, Camillo, CAPORALI, ROBERTO, MONTECUCCO, CARLOMAURIZIO   +2 more
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Thrombotic thrombocytopenic purpura in pregnancy

BJOG: An International Journal of Obstetrics & Gynaecology, 1982
Summary. A 20 week primigravida with intrauterine fetal death and the rare occurrence of thrombotic thrombocytopenic purpura (TTP) in pregnancy is presented. Aprotinin has been used to overcome uterine inertia non‐responsive to oxytocin stimulation. TTP was successfully treated with repeated plasmaphereses.
M, Atlas, G, Barkai, J, Menczer, N, Houlu, P, Lieberman   +4 more
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Thrombotic thrombocytopenic purpura in childhood

Pediatric Blood & Cancer, 2009
AbstractThrombotic thrombocytopenic purpura (TTP) is a rare disease, especially in childhood, and has a high mortality rate in the absence of appropriate treatment. It is characterised by microangiopathic haemolytic anaemia and consumptive thrombocytopenia.
Maria C, Bouw, Natasja, Dors, Heleen, van Ommen, Nicole L, Ramakers-van Woerden   +3 more
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Thrombotic Thrombocytopenic Purpura

Annual Review of Medicine, 1988
Platelet thrombus formation in small vessels is triggered by certain stimuli, including vascular injury, primary platelet agglutination, or both. The formation and dissolution of platelet thrombi is modulated by proteolysis, plasma factors, PGI2 synthesis and stability, and immune mechanisms.
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Thrombotic Thrombocytopenic Purpura

Annals of Internal Medicine, 1980
Excerpt Originally described in 1925 (1), thrombotic thrombocytopenic purpura remained until recently a fulminating and rapidly fatal disorder. Fortunately, it has been rare.
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Thrombotic Thrombocytopenic Purpura and Vincristine

JAMA: The Journal of the American Medical Association, 1982
To the Editor.— We were interested in the recent article inThe Journal(1982;247:1433) by Lorence A. Gutterman, MD, and Thomas D. Stevenson, MD, which demonstrates that vincristine sulfate is capable of inducing remissions in patients with thrombotic thrombocytopenic purpura (TTP).
W J, Gundlach, R, Tarnasky
openaire   +2 more sources