Results 221 to 230 of about 94,849 (390)

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

Molecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp, Wouter P. R. Verdurmen, Jonas V. Schaefer, Kari Kopra, Gabriela Nagy‐Davidescu, Elodie Richard, Marie‐Julie Nokin, Patrick Ernst, Rastislav Tamaskovic, Martin Schwill, Ralph Degen, Claudia Scholl, David Santamaria, Andreas Plückthun   +13 more
wiley   +1 more source

A Review of OBD-II-Based Machine Learning Applications for Sustainable, Efficient, Secure, and Safe Vehicle Driving. [PDF]

Sensors (Basel)
Michailidis ET, Panagiotopoulou A, Papadakis A.   +2 more
europepmc   +1 more source

Robust &#x210B;<inf>2</inf> static output feedback to control an automotive throttle valve [PDF]

, 2014
Alessandro N. Vargas, Leonardo Acho, Gisela Pujol, Ricardo C. L. F. Oliveira, J.B.R. do Val, Pedro L. D. Peres   +5 more
openalex   +1 more source

Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias, Ana Oitabén, Sonia Zumalave, Bernardo Rodriguez‐Martin, María Gallardo‐Gómez, Martín Santamarina, Ana Pequeño‐Valtierra, Laura Juaneda‐Magdalena, Ramón García‐Escudero, José Luis López‐Cedrún, Máximo Fraga, José M. C. Tubio, Mónica Martínez‐Fernández   +12 more
wiley   +1 more source

Numerical Simulation of Supercritical CO₂ Blocking Flow Based on the Peng-Robinson Equation. [PDF]

ACS Omega
Xing X, Chen H, Ma Y, Yu J, Ren J, Shen H, Gao W, Peng J, Li M.   +8 more
europepmc   +1 more source

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

Molecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

Experimental investigation on impact of fuel jet size on performance of gasoline-ethanol blend in a SI engine vehicle. [PDF]

Sci Rep
Tafesse D, Nallamothu RB.
europepmc   +1 more source

Simulation and Experimental Study of a Novel Negative-Pressure Flapper-Nozzle Mechanism. [PDF]

Micromachines (Basel), 2023
Ma A, Xiao H, Yan X, Kong X, Rong F, Zhang L, Zhao S.   +6 more
europepmc   +1 more source

EMT‐associated bias in the Parsortix® system observed with pancreatic cancer cell lines

Molecular Oncology, EarlyView.
The Parsortix® system was tested for CTC enrichment using pancreatic cancer cell lines with different EMT phenotypes. Spike‐in experiments showed lower recovery of mesenchymal‐like cells. This was confirmed with an EMT‐inducible breast cancer cell line.
Nele Vandenbussche, Renske Imschoot, Béatrice Lintermans, Lode Denolf, Joachim Taminau, Charlotte Fieuws, Geert Berx, Kris Gevaert, Kathleen B. M. Claes   +8 more
wiley   +1 more source

Development of a battery free, solar powered, and energy aware fixed wing unmanned aerial vehicle. [PDF]

Sci Rep
Liller J, Goel R, Aziz A, Hester J, Nguyen P.   +4 more
europepmc   +1 more source