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Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source

Experimental assessment of using phase change materials in vapor compression refrigeration systems for condenser pre-cooling. [PDF]

Heliyon
Riahi A, Shafii MB.
europepmc +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source

Design and Flight Experiment of a Motor-Directly-Driven Flapping-Wing Micro Air Vehicle with Extension Springs. [PDF]

Biomimetics (Basel)
Choi S, Oh C, Kang T, Park J.
europepmc +1 more source

Hydrogen doping control method for gasoline engine acceleration transient air-fuel ratio. [PDF]

Heliyon
Hu Z, Zhang Y, Ai Z, Li M, Zhang Y.
europepmc +1 more source

A new model for compressor surge and stall control. [PDF]