Results 121 to 130 of about 151,356 (287)

Thymidine Phosphorylase/β-tubulin III expressions predict the response in Chinese advanced gastric cancer patients receiving first-line capecitabine plus paclitaxel

BMC Cancer, 2011
Background To assess the role of Thymidine Phosphorylase and β-tubulin III in clinical outcome of Chinese advanced gastric cancer patients receiving first-line capecitabine plus paclitaxel.
Shen Lin, Li Yan-yan, Yu Jing-wei, Lu Ming, Gao Jing   +4 more
doaj   +1 more source

Noncanonical Nucleotides in the Genome Around the Maternal‐Zygotic Transition

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
In this paper, Kazzazi et al. provide a comprehensive review of the dynamics of nonconventional nucleotides in the genome during early developmental stages, hypothesizing a potential role for these nucleotides in the activation of the zygotic genome. ABSTRACT From the very moment of fertilization and throughout development, the cells of animal embryos ...
Latifa Kazzazy, Dávid Mező, Kinga K. Nagy, Viktória Perey‐Simon, Judit Tóth, Angéla Békési, Beáta Vértessy, Máté Varga   +7 more
wiley   +1 more source

Remission of invasive, cancer stem-like glioblastoma xenografts using lentiviral vector-mediated suicide gene therapy

, 2009
Background: Glioblastoma is the most frequent and most malignant primary brain tumor with a poor prognosis. The translation of therapeutic strategies for glioblastoma from the experimental phase into the clinic has been limited by insufficient animal ...
Oleg Tsinkalovsky, Euskirchen Philipp, Tsanan Giroglou, Huszthy, Peter C., Giroglou Tsanan, Skaftnesmo, Kai Ove, Miletic, Hrvoje, Miletic Hrvoje, Peter C Huszthy, Kai Ove Skaftnesmo, Tsinkalovsky Oleg, von Laer Dorothee, Euskirchen, Philipp, Dorothee von Laer, Hrvoje Miletic, Laer, Dorothee von, Rolf Bjerkvig, Giroglou, Tsanan, Tsinkalovsky, Oleg, Huszthy Peter C., Skaftnesmo Kai Ove, Bjerkvig Rolf, Philipp Euskirchen, Bjerkvig, Rolf   +23 more
core   +1 more source

A Nonlinear Quantitative Model for Measuring Concentration Ratios From Raman Intensities

Journal of Raman Spectroscopy, EarlyView.
Estimating concentration from Raman intensity ratios is complicated by cross‐contributions from overlapping peaks, causing measured ratios to deviate from the linear behavior assumed in conventional quantitative models. This nonlinear method fully accounts for cross‐contributions, allowing estimation of concentration over several orders of magnitude ...
Joseph Razzell Hollis
wiley   +1 more source

Aliphatic Poly(Carbonate)s with Acid Responsive Release Mechanisms for Micellar Anti‐Tumor Drug Delivery

Macromolecular Rapid Communications, EarlyView.
Micellar systems based on biodegradable aliphatic polycarbonates and acid‐responsive triggers enhance drug solubility, stability, and tumor‐selective release. This review covers micelles with acid‐cleavable drug linkages and those that disassemble via acid‐sensitive functionalities.
Adrian V. Hauck, Lutz Nuhn
wiley   +1 more source

Thymidine kinase diversity in bacteria

, 2006
Thymidine kinases (TKs) appear to be almost ubiquitous and are found in nearly all prokaryotes, eukaryotes, and several viruses. They are the key enzymes in thymidine salvage and activation of several anti-cancer and antiviral drugs.
Clausen, A.R., Munch-Petersen, B., Sandrini, Michael,, Piskur, Jure, Clausen, Anders R., Clausen, Anders Ranegaard,, Clausen, Anders Ranegaard, Sandrini, Michael, Sandrini, Michael P., Lund University., Munch-Petersen, Birgitte   +10 more
core   +1 more source

Microbially driven organic carbon cycling at the land−sea interface: Advances and an integrated study framework

mLife, EarlyView.
Abstract The land−sea interface is a vital component of global biogeochemical cycles, where microorganisms drive the cycling of carbon, nitrogen, and sulfur. This review synthesizes the research progress from representative land−sea interfaces to elucidate how the microbial community structure and metabolic function influence the mobilization ...
Quanrui Chen, Kai Tang, Zhili He, Meng Li, Jun Yang, Weidong Zhai, Qiang Zheng, Nianzhi Jiao   +7 more
wiley   +1 more source

The prognostic and therapeutic significance of biological molecular markers in human anorectal carcinomas treated with 5'fluorouracil chemoradiation.

, 2005
Advances in tumour biology have led to studies of new biological markers, which may predict treatment response and clinical outcome independently of standard clinicopathological variables.
Mawdsley, S.K.V.
core  

Thymidine Kinase 2 Enzyme Kinetics Elucidate the Mechanism of Thymidine-Induced Mitochondrial DNA Depletion

, 2014
Mitochondrial thymidine kinase 2 (TK2) is a nuclear gene-encoded protein, synthesized in the cytosol and subsequently translocated into the mitochondrial mateix, where it catalyzes the phosphorylation of thymidine (dT) and deoxycytidine (dC).
Sun, Ren,, Sveriges lantbruksuniversitet., Wang, Liya,   +2 more
core   +1 more source

Boron‐10 carriers and their applications in boron neutron capture therapy

Precision Radiation Oncology, EarlyView.
Summary of different types of boron drugs. Abstract Boron neutron capture therapy (BNCT) has emerged as a promising therapeutic modality in cancer treatment, demonstrating the ability to selectively eliminate cancer cells through the 10B(n,α)7Li nuclear reaction with minimal side effects on normal tissues.
Dachao Tang, Mengqi Shi, Zhichen Mao, Weiya Chen, Xiaoling Li, Xiao Yan Zhao, Zhigang Liu, Xiao Xu   +7 more
wiley   +1 more source