Results 121 to 130 of about 162,084 (246)

Hiding Human Thymidine Kinase 1 from Apc/C-Mediated Destruction by Thymidine Binding

, 2008
Thymidine kinase 1 (TK1) is a key cytosolic enzyme in the salvage pathway for dTTP synthesis. In mitotic exit, human TK1 (hTK1) is degraded via the anaphase-promoting complex/ cyclosome (APC/C)-Cdh1 pathway to limit dTTP production.
柯博元;張益昌;張智芬, KE, PO-YUAN;CHANG, YI-CHANG;CHANG, ZEE- FEN   +1 more
core  

Senotherapeutics for Knee Osteoarthritis

Medicinal Research Reviews, EarlyView.
ABSTRACT Osteoarthritis (OA) is a chronic disease that imposes a significant economic burden and deteriorates quality of life. Nevertheless, current therapeutic options for OA are limited to symptomatic remedies. As such, there is a high interest in novel methods for treating or preventing OA.
Ezgi Duman, Girish Pattappa, Patrick Pann, Stephan Reppenhagen, Maximilian Rudert, Peter Angele, Denitsa Docheva   +6 more
wiley   +1 more source

Rational Design of 5‘-Thiourea-Substituted α-Thymidine Analogues as Thymidine Monophosphate Kinase Inhibitors Capable of Inhibiting Mycobacterial Growth

, 2016
Recently, thymidine monophosphate kinase (TMPK) emerged as an attractive target for developing inhibitors of Mycobacterium tuberculosis growth. The elucidation of the X-ray structure of TMPK of M.
Jan Balzarini (161754), Hélène Munier-Lehmann (399503), Serge Van Calenbergh (125212), Ineke Van Daele (2306956), Matheus Froeyen (2470210)   +4 more
core   +1 more source

In planta analysis of the mode of action of cinmethylin and confirmation of fatty acyl‐ACP thioesterases (FATs) as primary site of action

Pest Management Science, EarlyView.
In planta analysis of the mode of action of cinmethylin and confirmation of fatty acyl‐ACP thioesterases (FATs) as primary site of action. Cinmethylin inhibits FATs, disrupting eukaryotic de novo lipid biosynthesis and causing defects in cell division, elongation and integrity. We confirm FATs as the primary site of action in planta.
Maximillian Pollmeier, Aisha Gerhardt, Janneke Hendriks, Katharina Kaprocki, Alexandra Zimmermann, Sarina Ruehm, Martina Marnet, Maria Stroe, Jorge Alfredo Rojas Biava, Clara Hofmann, Michael Betz, Sascha Schlaefer, Philipp Ternes, Jens Lerchl, Selene Garcia‐Hernandez, Philipp Johnen   +15 more
wiley   +1 more source

Elimination of 15N-thymidine after oral administration in human infants.

PLoS ONE
BackgroundWe have developed a new clinical research approach for the quantification of cellular proliferation in human infants to address unanswered questions about tissue renewal and regeneration.
Niyatie Ammanamanchi, Jessie Yester, Anita P Bargaje, Dawn Thomas, Kathryn C Little, Shannon Janzef, Kimberly Francis, Jacqueline Weinberg, Jennifer Johnson, Thomas Seery, Tyler Hutchinson Harris, Bryan J Funari, Kirsten Rose-Felker, Matthew Zinn, Susan A Miller, Shawn C West, Brian Feingold, Hairu Zhou, Matthew L Steinhauser, Timothy Csernica, Robert Michener, Bernhard Kühn   +21 more
doaj   +1 more source

Combining Laser‐Induced Edition to Collision‐Induced Sequencing of Digital Oligomers in a Single Gas‐Phase Experiment

Rapid Communications in Mass Spectrometry, EarlyView.
ABSTRACT Rationale To increase the confidentiality level of molecular tags, binary information can be hidden in sequence‐defined oligomers using isobaric monomers including a photo‐sensitive one, which mass can be modified upon light irradiation. Reading such secured data requires light edition prior to MS/MS sequencing, which was investigated here in ...
Clothilde Comby‐Zerbino, Jean‐François Lutz, Luke MacAleese, Laurence Charles   +3 more
wiley   +1 more source

Thymidine kinase, thymidylate synthase, and endothelial cell growth under hyperoxia

, 1987
To determine the respective role of thymidine kinase and thymidylate synthase activities in the hyperoxia-induced decrease in DNA synthesis and their relationship with cell replication, we measured these two enzyme activities in primary cultures of ...
L. Jornot, A. F. Junod, H. Petersen
core   +1 more source

Impact of Positively Charged Backbone Modifications on the Properties of Spherical Nucleic Acids

Small, EarlyView.
A synthesis of spherical nucleic acids (SNAs) featuring cationic backbone modifications is presented, together with an analysis of their emerging properties. Introducing positively charged guanidinium groups near the SNA surface enhances cellular uptake and offers a pathway toward more precise control over SNA internalization.
Katherine E. Bujold, Kacper Skakuj, John P. Cavaliere, Caroline D. Kusmierz, Chad A. Mirkin   +4 more
wiley   +1 more source

In Silico Analysis of Active Compounds from Allium tuberosum as Drug Candidate for Inhibitor DENV-3 Envelope Protein

Jurnal Ilmu Dasar
Dengue fever has become a global health issue, the development of dengue vaccine has not yet been established. Medicinal plants are an ideal alternative for DENV infection drugs.
Moh Mirza Nuryady, Levina Imelda Juliana, Kiky Martha Ariesaka   +2 more
doaj   +1 more source

Photoactivation of Electron Donor–Acceptor Complexes Enables Deoxygenative Hydrogenation and Deuteration

Transformative Chemistry, EarlyView.
A photoinduced, NHC‐borane‐enabled radical deoxygenative hydrogenation featuring mild reaction conditions and excellent functional group tolerance has been developed. The reaction proceeds through a novel EDA complex photoactivation pathway. To explore the potential of NHC‐boranes in deuteration reactions, we developed a novel photoinduced protocol for
Mengqing Zhang, Changlei Zhu, Jingjing Wu   +2 more
wiley   +1 more source