Results 131 to 140 of about 151,356 (287)
Precision Radiation Oncology, EarlyView.Boron neutron capture therapy (BNCT) requires key non‐negotiable technical criteria: megadose administration, precise tumor‐specific targeting, favorable biocompatibility, and sustained tumor retention. Overcoming these interconnected challenges fundamentally depends on biomolecular carriers, which are critical for translating the therapeutic potential
Chang Chen +6 more
wiley +1 more source
Carrier erythrocyte entrapped thymidine phosphorylase therapy for MNGIE [PDF]
, 2008 Bax, BE +11 more
core +1 more source
, 2016 Recently, thymidine monophosphate kinase (TMPK) emerged as an attractive target for developing inhibitors of Mycobacterium tuberculosis growth. The elucidation of the X-ray structure of TMPK of M.
Jan Balzarini (161754) +4 more
core +1 more source
Epigenetic Regulation of Immune Dysfunction in Chronic Prostatitis/Chronic Pelvic Pain Syndrome
The Prostate, EarlyView.ABSTRACT Background Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is a prevalent and debilitating condition with unclear etiology. Increasing evidence implicates immune dysregulation, yet the molecular mechanisms underlying impaired immune regulation remain poorly defined. This study investigated the role of altered immune responses within
Praveen Thumbikat +8 more
wiley +1 more source
Thymidine salvage and de novo synthesis pathways.
, 2013 In thymidine salvage, thymidine is transported across the cell membrane and phosphorylated by TK1 into thymidine monophosphate (TMP). The thymidine is further phosphorylated into thymidine diphosphate (TDP) and thymidine triphosphate (TTP) and then ...
R. Adam Smith (314492) +7 more
core +1 more source
Rapid Communications in Mass Spectrometry, EarlyView.ABSTRACT Rationale To increase the confidentiality level of molecular tags, binary information can be hidden in sequence‐defined oligomers using isobaric monomers including a photo‐sensitive one, which mass can be modified upon light irradiation. Reading such secured data requires light edition prior to MS/MS sequencing, which was investigated here in ...
Clothilde Comby‐Zerbino +3 more
wiley +1 more source
Hiding Human Thymidine Kinase 1 from Apc/C-Mediated Destruction by Thymidine Binding
, 2008 Thymidine kinase 1 (TK1) is a key cytosolic enzyme in the salvage pathway for dTTP synthesis. In mitotic exit, human TK1 (hTK1) is degraded via the anaphase-promoting complex/ cyclosome (APC/C)-Cdh1 pathway to limit dTTP production.
柯博元;張益昌;張智芬 +1 more
core
Metabolome Diversity Enhances Resistance of Intertidal Clams to Thermal Stress
Integrative Zoology, EarlyView.Meretrix species are widely distributed intertidal bivalves in China with significant ecological and economic importance, which are sensitive to thermal stress. Our results showed that thermal environments of clam habitats shaped metabolome diversity, which can enhance the resistance of intertidal clams to thermal stress.
Zhi Hu +5 more
wiley +1 more source
Molecular imaging using positron emission tomography in gastrointestinal malignancy
, 2010 Positron Emission Tomography (PET) with 18F-FDG has emerged as a powerful tool in oncology. Furthermore, recent advent of PET/CT and novel tracers are continually expanding its role.
Pakzad, F.
core
Cellular pathway of thymidine with the interaction of pemetrexed indicated.
, 2013 18F-FLT is not incorporated into DNA, as shown by the dotted arrow. Abbreviations: ENT, Equilibrative Nucleoside Transporter; TMP, Thymidine Monophosphate; TDP, Thymidine Diphosphate; TTP, Thymidine Triphospate; dNT, deoxyribonucleotidase.
Godefridus J. Peters (121184) +9 more
core +1 more source