Results 131 to 140 of about 232,266 (302)
Synthesis of Oligonucleotide Conjugates Employing a Diselenide Linker
Chemistry – A European Journal, EarlyView.ABSTRACT In this study, we report the synthesis of an alkylene linker containing a terminal 2‐cyanoethyl protected selenium functionality for coupling at the 5'‐end of an oligonucleotide by solid phase synthesis for the preparation of oligonucleotide conjugates.
Shivam Tikoo +2 more
wiley +1 more source
Fluorogenic Sydnones for Bioorthogonal Labeling of DNA
Chemistry – A European Journal, EarlyView.Conjugates of sydnones with cyanine‐styryl dyes combine bioorthogonal reactivity with fluorogenicity. The reactivity with bicyclo[6.1.0]non‐4‐yne (BCN)‐modified DNA showed second‐order rate constants of up to k2 = 2,300 M−1s−1 and fluorescence turn‐on by one magnitude of order.
Kerstin Müller +1 more
wiley +1 more source
Autodécomposition de thymidine tritiée en solution aqueuse [PDF]
, 2017 Les auteurs ont étudié, par chromatographie sur papier, les produits de décomposition formés, à 4 °C, dans une solution vieillie de thymidine tritiée.
Bernard Ekert, Sonia Apelgot
core +1 more source
Control of Gemcitabine Activity With Blue and Red Light
Chemistry – A European Journal, EarlyView.Treating cancer with chemotherapy is generally associated with many side effects, which can be addressed by selectively releasing the desired drugs with visible light. Sixteen new blue light‐activatable cytostatics were introduced, with the gemcitabine derivative exhibiting ideal properties.
Nils F. Kersten +6 more
wiley +1 more source
Toxicologic effects of a high dose of thymidine in mice [PDF]
, 1980 The pharmacologic effects and plasma concentrations produced by the ip administration of high doses of thymidine were determined in CDF 1 mice. Within 15 min after the injection of thymidine at a dose of 4.075 g/kg (between LD0 and LD50), mean arterial ...
Jordan, William +5 more
core +1 more source
Biophysical processes of morphogenesis in lizard lungs
Developmental Dynamics, EarlyView.Abstract Background The lungs of squamate reptiles (lizards and snakes) are highly diverse, exhibiting single chambers, multiple chambers, transitional forms with two to three chambers, along with a suite of other anatomical features, including finger‐like epithelial projections into the body cavity known as diverticulae.
Kaleb Hill +9 more
wiley +1 more source
Mutants Affecting Thymidine Metabolism in Neurospora crassa [PDF]
, 1969 When 14C-thymidine labeled only in the ring is administered to Neurospora crassa, the majority of the recovered label is found in the ribonucleic acid (RNA).
Mitchell, H. K., Williams, Larry G.
core
Rational design of 5'-thiourea-substituted α-thymidine analogues as thymidine monophosphate kinase inhibitors capable of inhibiting mycobacterial growth [PDF]
, 2007 Recently, thymidine monophosphate kinase (TMPK) emerged as an attractive target for developing inhibitors of Mycobacterium tuberculosis growth. The elucidation of the X-ray structure of TMPK of M.
Froeyen, Matheus +5 more
core +2 more sources
Labeling DNA with Stable Isotopes: Economical and Practical Considerations
BioTechniques, 2001 Labeling DNA with stable isotopes to measure cell proliferation can be a technique as effective as 3H-thymidine labeling without the limitations imposed by using radioisotopes.
G.E. Black +4 more
doaj +1 more source
Jaw‐specific stem cell dynamics are associated with distinct enamel architecture in mouse incisors
Developmental Dynamics, EarlyView.Abstract Background The continuously growing mouse incisor serves as a model for stem cell‐driven tooth renewal. Although mice possess maxillary and mandibular incisors, most studies have focused on the mandible. Potential differences in structure and renewal between these serially homologous organs remain insufficiently characterized.
Elias Shahin +4 more
wiley +1 more source