Results 131 to 140 of about 1,176,884 (363)

IL4I1⁺ Macrophages and TDO2⁺ Myofibroblasts Drive AhR‐Mediated Immunosuppression and Ferroptosis Resistance in Solid Predominant Lung Adenocarcinoma

Advanced Science, EarlyView.
Solid predominant lung adenocarcinoma exhibits an immune‐excluded, ferroptosis‐resistant niche enriched with IL4I1⁺ TAMs and TDO2⁺ myCAFs. Spatial and multi‐omics analyses reveal AhR‐driven crosstalk that promotes T cell exhaustion and therapy resistance. Blocking AhR with CH‐223191 restores ferroptosis sensitivity, and its combination with ferroptosis
Zhaoxuan Wang, Weijiao Xu, Lei Zhao, Lin Zhong, Wendan Yu, Shengmin Wang, Lu Sun, Tao Guo, Fengzhou Li, Zhuoshi Li, Lei Fang, Shiqing Wang, Guohui Zhang, Guoqing Xue, Wei Guo, Shilei Zhao, Chundong Gu   +16 more
wiley   +1 more source

Adipokines and inflammation markers and risk of differentiated thyroid carcinoma: The EPIC study [PDF]

, 2017
Laure Dossus, Silvia Franceschi, Carine Biessy, Anne‐Sophie Navionis, Ruth C. Travis, Elisabete Weiderpass, Augustin Scalbert, Isabelle Romieu, Anne Tjønneland, Anja Olsen, Kim Overvad, Marie‐Christine Boutron‐Ruault, Fabrice Bonnet, A. Fournier, Renée T. Fortner, Rudolf Kaaks, Krasimira Aleksandrova, Antonia Trichopoulou, Carlo La Vecchia, Eleni Peppa, ­Rosario ­Tumino, Salvatore Panico, Domenico Palli, Claudia Agnoli, Paolo Vineis, H. Bas Bueno‐de‐Mesquita, Petra H. Peeters, Guri Skeie, Raúl Zamora‐Ros, María‐Dolores Chirlaque, Eva Ardanáz, María‐José Sánchez, J. Ramón Quirós, Miren Dorronsoro, Maria Sandström, Lena Nilsson, Julie A. Schmidt, Kay‐Tee Khaw, Konstantinos K. Tsilidis, Dagfinn Aune, Elio Ríboli, Sabina Rinaldi   +41 more
openalex   +1 more source

Microcystin‐LR Triggers Renal Tubular Ferroptosis Through Epigenetic Repression of GPX4: Implications for Environmental Nephrotoxicity

Advanced Science, EarlyView.
MC‐LR stabilizes DNMT1/3a by blocking their ubiquitin‐mediated degradation, leading to Gpx4 promoter hypermethylation and E2F4/NCoR‐associated transcriptional repression, which drives renal tubular ferroptosis in mice. Pharmacological inhibition of DNA methylation (SGI‐1027) or ferroptosis (Fer‐1) disrupts this DNMT‐GPX4 axis, thereby alleviating MC‐LR‐
Shaoru Zhang, Qi Gao, Yi Peng, Huan Zhang, Qi Shen, Meihong Guo, Yuqing Gong, Lei Chu, Weidong Wu, Yanting Wen, Wangsen Cao, Yong Wang, Lihui Wang   +12 more
wiley   +1 more source

Development and Validation of Machine Learning Models in Predicting Prognosis of Breast Cancer Patients with Lymph Nodes Metastasis Following Neoadjuvant Chemotherapy

Breast Cancer: Targets and Therapy
Yanjia Fan,1,* Yudi Jin,2,* Cheng Tian,1 Yu Zhang,1 Chi Zhang,1 Haochen Yu,1 Shengchun Liu1 1Department of Breast and Thyroid Surgery, the First Affiliated Hospital of Chongqing Medical University, Chongqing, People’s Republic of China ...
Fan Y, Jin Y, Tian C, Zhang Y, Zhang C, Yu H, Liu S   +6 more
doaj  

Monitoring thyroid function status in elderly patients on amiodarone [PDF]

, 2006
Objectives: To evaluate whether elderly patients on amiodarone were having their thyroid function status monitored as recommended in the literature and to identify the frequency and type of thyroid function test abnormalities noted.
Fiorini, Anthony
core  

Thyroid function in children with sepsis and septic shock [PDF]

, 2006
Rakesh Lodha, S Vivekanandhan, Manjunatha Sarthi, S Arun, S. K. Kabra   +4 more
openalex   +1 more source

Osmotic Tension Asymmetry Drives Electrotactic Migration via PDLIM7‐Polarized Microfilament Coordination in Breast Cancer Cells

Advanced Science, EarlyView.
This study establishes an electric field‐induced directional migration model using fluorescence tension probes to visualize microfilament forces and intracellular osmotic pressure dynamics in the electrotactic migration of breast cancer cells. This model delineates how electromechanical interactions among membrane potential, ion channels, OP, traction ...
Ling Zhu, Zihui Zheng, Wang Li, Chenyi Shou, Ying Zhao, Lijun Zhang, Xiaoli Shi, Yunfeng Hu, Huanhuan Zhao, Huiwen Wu, Jun Guo   +10 more
wiley   +1 more source

Cell and Molecular Biology of Thyroid Disorders 2.0 [PDF]

, 2021
Daniela Grimm
openalex   +1 more source

Halorotetin B, A Novel Terpenoid Compound Derived from Marine Ascidian, Suppresses Tumor Growth by Targeting the Cell Cycle Regulator UBE2C

Advanced Science, EarlyView.
Halorotetin B, a novel small‐molecule terpenoid identified from an edible marine ascidian, exhibits strong anti‐tumor activity both in vitro and in vivo through direct targeting UBE2C to induce tumor cell cycle arrest and then lead tumor cell senescence. As a newly discovered UBE2C inhibitor, Halorotetin B can serve as a novel potential cell senescence
Shanhao Han, Jianhui Li, Yuting Zhu, Penghui Liu, Yaoyao Zheng, Muchun He, Bo Dong   +6 more
wiley   +1 more source

Recurrent Hormone Receptor–Positive Breast Cancer With Multiple Sites of Distant Metastasis: A Case Report and Review of the Literature

International Journal of Breast Cancer
Breast cancer is one of the most common malignancies and the leading cause of cancer-related mortality among women worldwide, with hormone receptor–positive (HR+) breast cancer being the most common subtype. Current guidelines recommend endocrine therapy
Lu Li, Hui Liu, Xiangxin Huang, Haojun Luo   +3 more
doaj   +1 more source